Results 101 to 110 of about 219,417 (396)

Hematologic Toxicity of Concurrent Administration of Radium-223 and Next-generation Antiandrogen Therapies. [PDF]

, 2017
PURPOSE/OBJECTIVES: Radium-223 is a first-in-class radiopharmaceutical recently approved for the treatment of castration-resistant prostate cancer in patients with symptomatic bone metastases.
Basch, Beer, Chen, Cookson, De Bono, Den, Dreicer, Fizazi, Hoskin, Kantoff, Keizman, Morris, Nilsson, Nilsson, Parker, Petrylak, Ryan, Scher, Siegel, Tannock, Tu   +20 more
core   +2 more sources

The Castration Of Cryptorchids [PDF]

Journal of Comparative Pathology and Therapeutics, 1889
n ...
openaire   +3 more sources

TheraP: a randomized phase 2 trial of 177Lu‐PSMA‐617 theranostic treatment vs cabazitaxel in progressive metastatic castration‐resistant prostate cancer (Clinical Trial Protocol ANZUP 1603)

BJU International, 2019
To assess the activity and safety of cabazitaxel chemotherapy vs that of treatment with 177Lu‐PSMA‐617, a novel radiolabelled small molecule that binds with high affinity to prostate‐specific membrane antigen (PSMA), in men with metastatic castration ...
M. Hofman, L. Emmett, J. Violet, Alison Y Zhang, N. Lawrence, M. Stockler, R. Francis, A. Iravani, S. Williams, A. Azad, A. Martin, M. McJannett, I. Davis   +12 more
semanticscholar   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

A correlative biomarker study and integrative prognostic model in chemotherapy‐naïve metastatic castration‐resistant prostate cancer treated with enzalutamide

The Prostate, Volume 83, Issue 4, Page 376-384, March 2023., 2023
Abstract Background There is a considerable need to incorporate biomarkers of resistance to new antiandrogen agents in the management of castration‐resistant prostate cancer (CRPC). Methods We conducted a phase II trial of enzalutamide in first‐line chemo‐naïve asymptomatic or minimally symptomatic mCRPC and analyzed the prognostic value of TMPRSS2‐ERG
María P. Fernandez‐Perez, Enrique Perez‐Navarro, Teresa Alonso‐Gordoa, Vicenza Conteduca, Albert Font, Sergio Vázquez‐Estévez, Aránzazu González‐del‐Alba, Daniel Wetterskog, Emmanuel S. Antonarakis, Begona Mellado, Ovidio Fernandez‐Calvo, María J. Méndez‐Vidal, Miguel A. Climent, Ignacio Duran, Enrique Gallardo, Angel Rodriguez Sanchez, Carmen Santander, Maria I. Sáez, Javier Puente, Julian Tudela, Alberto Martínez, Maria J. López‐Andreo, José Padilla, Rebeca Lozano, David Hervas, Jun Luo, Ugo de Giorgi, Daniel Castellano, Gerhardt Attard, Enrique Grande, Enrique Gonzalez‐Billalabeitia   +30 more
wiley   +1 more source

Sugarcane bagasse or elephant grass hay in diets for goats: Performance, feeding behavior and carcass characteristics

Revista Colombiana de Ciencias Pecuarias, 2021
Background: Novel feeding strategies should be developed to produce high-quality meat in current goat production systems. Objective: To evaluate the effects of castration and the association of spineless cactus with sugarcane bagasse or elephant grass ...
Victor H. Campelo-Lima, Stela Antas-Urbano, Marcelo Andrade-Ferreira, Pedro H. Cavalcante-Ribeiro, José I. Gomes-Bezerra, Juana C. Cariri-Chagas, Emerson Moreira-Aguiar, Adriano H. Nascimento-Rangel   +7 more
doaj   +1 more source

Androgen receptors beyond prostate cancer: an old marker as a new target. [PDF]

, 2014
Androgen receptors (ARs) play a critical role in the development of prostate cancer. Targeting ARs results in important salutary effects in this malignancy.
Kurzrock, Razelle, Munoz, Javier, Wheler, Jennifer J   +2 more
core   +2 more sources

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

Les formes de la separation dans les Lettres persanes

Revista Criação & Crítica, 2017
Cet article aborde la thématique de la séparation dans le dispositif romanesque des Lettres persanes, de Montesquieu, à savoir, le roman du sérail. De ce fait, cette étude entend analyser les formes de la séparation qui aparaissent dans les lettres des ...
Thaïs Chauvel
doaj   +1 more source

An extended reply to Mendez et al.: The 'extremely ancient' chromosome that still isn't [PDF]

arXiv, 2014
Earlier this year, we published a scathing critique of a paper by Mendez et al. (2013) in which the claim was made that a Y chromosome was 237,000-581,000 years old. Elhaik et al. (2014) also attacked a popular article in Scientific American by the senior author of Mendez et al.
arxiv