Results 21 to 30 of about 83,207 (290)

A comprehensive analysis of coregulator recruitment, androgen receptor function and gene expression in prostate cancer

eLife, 2017
Standard treatment for metastatic prostate cancer (CaP) prevents ligand-activation of androgen receptor (AR). Despite initial remission, CaP progresses while relying on AR. AR transcriptional output controls CaP behavior and is an alternative therapeutic
Song Liu, Sangeeta Kumari, Qiang Hu, Dhirodatta Senapati, Varadha Balaji Venkadakrishnan, Dan Wang, Adam D DePriest, Simon E Schlanger, Salma Ben-Salem, Malyn May Valenzuela, Belinda Willard, Shaila Mudambi, Wendy M Swetzig, Gokul M Das, Mojgan Shourideh, Shahriah Koochekpour, Sara Moscovita Falzarano, Cristina Magi-Galluzzi, Neelu Yadav, Xiwei Chen, Changshi Lao, Jianmin Wang, Jean-Noel Billaud, Hannelore V Heemers   +23 more
doaj   +1 more source

Surgical castration in dogs: does the incision approach influence postoperative recovery?

Veterinary Evidence, 2022
PICO question In male dogs undergoing surgical castration, does a pre-scrotal approach in comparison to a scrotal approach lead to a superior recovery, in terms of duration of postoperative pain and/or reduced post-operative complications?   Clinical
Ariel Brunn
doaj   +1 more source

Use of Meloxicam or Ketoprofen for Piglet Pain Control Following Surgical Castration

Frontiers in Veterinary Science, 2018
Surgical castration of piglets is performed routinely on commercial pig farms, to prevent boar taint and minimize aggression. While this procedure is known to be painful, piglets are generally not provided any analgesic for pain relief, leading to ...
Abbie V. Viscardi, Patricia V. Turner
doaj   +1 more source

Electroencephalography Can Distinguish between Pain and Anaesthetic Intervention in Conscious Lambs Undergoing Castration

Animals, 2020
Australian sheep routinely undergo painful surgical husbandry procedures without anaesthesia or analgesia. Electroencephalography (EEG) has been shown to be a successful measure of pain in livestock under a general anaesthetic.
Charissa Harris, Peter John White, Virginia L. Mohler, Sabrina Lomax   +3 more
doaj   +1 more source

Effects of lidocaine-plus-meloxicam treatment on behavioral and physiological changes, and leukocyte heat shock protein 90 gene expression after surgical castration in Hanwoo bulls

Frontiers in Veterinary Science
This study examined the effects of surgical castration and lidocaine-plus-meloxicam treatment on growth, physiology, behaviors, and leukocyte heat shock protein 90 (HSP 90) gene expression in Hanwoo (Korean cattle) bulls. Twenty Hanwoo bulls (body weight
Ingu Cho, Seonpil Yoo, Da Jin Sol Jung, Jaesung Lee, Seok-Hyeon Baek, Sang Yeob Kim, Jinoh Lee, Dohyun Kim, Hyun Jin Kim, Myunggi Baik, Myunggi Baik   +10 more
doaj   +1 more source

Efficacy and Safety of 4.7 mg Deslorelin Acetate Implants in Suppressing Oestrus Cycle in Prepubertal Female Dogs

Animals, 2022
Our multicentric, masked, controlled and randomised study aimed to assess the efficacy and safety of Suprelorin® 4.7 mg (Virbac, Carros, France) regarding oestrus prevention in prepubertal intact bitches.
Aymeric Gontier, Myriam Youala, Christelle Fontaine, Elsa Raibon, Sandrine Fournel, Philippe Briantais, Delphine Rigaut   +6 more
doaj   +1 more source

Effects of Castration Age on the Growth Performance of Nubian Crossbred Male Goats

Animals, 2022
To determine the optimal timing for performing castration on goats, eighteen male Nubian crossbred goats were randomly assigned to two groups and castrated at 3 months and 6 months of age, respectively. Daily dry matter intake, biweekly body weights, and
Yu-An Chen, Jing-Yan Chen, Wei-Qun Chen, Wen-Yen Wang, Hsi-Hsun Wu   +4 more
doaj   +1 more source

Responsible ownership for cats and dogs from different urban neighborhoods of the City of Umuarama, Paraná, Brazill

Brazilian Journal of Veterinary Medicine, 2020
The article analyzed the responsible care and well-being of dogs and cats of different districts of the municipality of Umuarama, PR. We interviewed 53 tutors by means of a directed questionnaire, obtaining 106 animals evaluated indirectly.
Thaís Camaso de Sá, Jessé Lahos Borges, Ana Maria Quessada, Antônio Sérgio Ferraudo, Eduardo Herrera Dias, Marco Aurélio Cunha del Vechio, Pollyana Linhares Sala, Mayara da Silva Trentim, Luciana Kazue Otutumi   +8 more
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Effect of a topical anaesthetic formulation on the cortisol response to surgical castration of unweaned beef calves

Animal, 2016
Impracticality and cost of existing pain management strategies during surgical castration of beef cattle have limited their widespread implementation on-farm. A farmer-applied topical anaesthetic formulation, originally developed and used commercially to
D. McCarthy, S. Lomax, P.A. Windsor, P.J. White   +3 more
doaj   +1 more source