Results 1 to 10 of about 303,763 (330)
Associations between purine metabolites and clinical symptoms in schizophrenia [PDF]
, 2012 Background: The antioxidant defense system, which is known to be dysregulated in schizophrenia, is closely linked to the dynamics of purine pathway. Thus, alterations in the homeostatic balance in the purine pathway may be involved in the pathophysiology
Debra M. Montrose +9 more
core +10 more sources
Withaferin A and Ovarian Cancer Antagonistically Regulate Skeletal Muscle Mass
Frontiers in Cell and Developmental Biology, 2021 Cachexia is a complex wasting syndrome that overwhelmingly affects the majority of late-stage cancer patients. Additionally, there are currently no efficacious therapeutic agents to treat the muscle atrophy induced by the cancer.
Alex R. Straughn +3 more
doaj +1 more source
European Journal of Histochemistry, 2022 HMGB1 is a highly conserved nuclear protein that is rapidly released into the extracellular environment during infection or tissue damage. In osteoarthritis, HMGB1 acts as a pro-inflammatory cytokine inducing a positive feedback loop for synovial ...
Yan Yan Li +4 more
doaj +1 more source
Heme Scavenging and Delivery: The Role of Human Serum Albumin
Biomolecules, 2023 Heme is the reactive center of several metal-based proteins that are involved in multiple biological processes. However, free heme, defined as the labile heme pool, has toxic properties that are derived from its hydrophobic nature and the Fe-atom ...
Giovanna De Simone +4 more
doaj +1 more source
Metabolic Fate Is Defined by Amino Acid Nature in Gilthead Seabream Fed Different Diet Formulations
Animals, 2022 The sustainability of the Aquaculture industry relies on optimising diets to promote nitrogen retention and maximise fish growth. The aim of this study was to assess how different dietary formulations influence the bioavailability and metabolic fate of ...
Rita Teodósio +4 more
doaj +1 more source
Perioperative catabolism [PDF]
Canadian Journal of Anesthesia/Journal canadien d'anesthésie, 2015 This article reviews the pathophysiology, clinical relevance, and therapy of the catabolic response to surgical stress.The key clinical features of perioperative catabolism are hyperglycemia and loss of body protein, both metabolic consequences of impaired insulin function.
Thomas, Schricker, Ralph, Lattermann
openaire +2 more sources
Branched-chain amino acids catabolism and cancer progression: focus on therapeutic interventions
Frontiers in Oncology, 2023 Branched-chain amino acids (BCAAs), including valine, leucine, and isoleucine, are crucial amino acids with significant implications in tumorigenesis across various human malignancies.
Er Xu, Bangju Ji, Ketao Jin, Yefeng Chen
doaj +1 more source
Pharmaceutics, 2021 Melatonin (MLT) is a pineal hormone involved in the regulation of the sleep/wake cycle. The efficacy of exogenous MLT for the treatment of circadian and sleep disorders is variable due to a strong liver metabolism effect.
Irene Moroni, Alfonso E. Garcia-Bennett
doaj +1 more source
Cancer Cachexia Induces Preferential Skeletal Muscle Myosin Loss When Combined With Denervation
Frontiers in Physiology, 2020 Patients with cancer cachexia (CCX) suffer from muscle wasting, which is often but not always accompanied by selective loss of myosin. Here we examined the effects of CCX on muscle mass and myosin heavy chain (MyHC) expression in denervated (DEN) muscles,
Takashi Yamada +4 more
doaj +1 more source
The hierarchy of sugar catabolization in Lactococcus cremoris
Microbiology Spectrum, 2023 Bacteria adapt to nutrient availability by regulating the synthesis of enzymes. Transcriptome- and multi-sugar growth studies suggest that Lactococcus cremoris represses genes involved in the catabolization of lower growth rate-supporting (lower quality)
Sieze Douwenga +8 more
doaj +1 more source