Protective effects of paederoside in rotenone-induced cellular models of Parkinson's disease. [PDF]
Front Cell Dev BiolLang J, Xiong Z.
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Novel Roman domination-based graph energies for QSPR analysis of neuroprotective herbal compounds in Alzheimer's disease treatment. [PDF]
Front ChemSalini Jancy Rani A, Balamurugan BJ.
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Immunomodulatory effects of Yang He decoction on cyclophosphamide-induced immunosuppression in mice: restoration of immune organ integrity and cytokine balance. [PDF]
Front PharmacolWang Y +7 more
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Bioactivities of Natural Catalpol Derivatives
Current Medicinal Chemistry, 2019Catalpol, a famous molecule of iridoids, possesses extensive pharmacological activities. Our studies found that compounds with low-polarity substituents at the 6-O position of catalpol exhibited higher NF-κB inhibitory potency than catalpol. However, catalpol derivatives are not much focused.
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Abstract Feeding experiments with deuterium-labelled 8- epi -deoxyloganic acid, bartsioside and aucubin gave incorporation of all compounds into catalpol both in Scutellaria albida and Paulownia tomentosa . Dilution experiments with labelled 8- epi -deoxyloganic acid and unlabelled aucubin showed that aucubin is an intermediate in the biosynthesis
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Catalpol promotes mitochondrial biogenesis in chondrocytes
Archives of Physiology and Biochemistry, 2020The chondrocyte mitochondrial dysfunction has been considered to be associated with the pathogenesis of joint diseases. Catalpol is an active traditional Chinese medicine ingredient named Di-Huang, which is used widely to treat different diseases.
Dan, Chen, Jing, Guo, Longguang, Li
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Protective effects of catalpol on cardio-cerebrovascular diseases: A comprehensive review
Journal of Pharmaceutical Analysis, 2023 Catalpol, an iridoid glucoside isolated from Rehmannia glutinosa, has gained attention due to its potential use in treating cardio-cerebrovascular diseases (CVDs). This extensive review delves into recent studies on catalpol's protective properties in relation to various CVDs, such as atherosclerosis, myocardial ischemia, infarction, cardiac ...
Yongguo Dai
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Study on the inhibitive effect of Catalpol on diabetic nephropathy
Life Sciences, 2020Catalpol (Cat) can ameliorate oxide stress and inflammation caused by diabetic nephropathy (DN), but the molecular mechanisms are unclear. This study was designed to investigate the anti-diabetic effects of Cat and its potential mechanism.We constructed high-fat diet/streptozotocin (HFD/STZ)-induced DN mice and high glucose (HG)-induced podocyte model.
Jing Chen +7 more
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Effect of catalpol on diabetic nephropathy in rats
Phytomedicine, 2013To investigate the effect of catalpol on diabetic nephropathy in rats.Male Sprague-Dawley rats were randomly divided into two groups and fed with normal pallet diet (NPD) or high-fat diet (HFD) for 4 weeks respectively. Then the HFD-fed rats were injected with 35 mg/kg streptozotocin (STZ) for establishing diabetic model.
Zhao, Dong, Chang Xun, Chen
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Catalpol: A Potential Therapeutic for Neurodegenerative Diseases
Current Medicinal Chemistry, 2015Neurodegenerative disorders, e.g., Alzheimer's disease (AD) and Parkinson's disease (PD) are characterized by the progressive loss of neurons and subsequent cognitive decline. They are mainly found in older populations. Due to increasing life expectancies, the toll inflicted upon society by these disorders continues to become heavier and more prominent.
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