Results 131 to 140 of about 1,785 (172)

Catalpol Ameliorates Neointimal Hyperplasia in Diabetic Rats

Planta Medica, 2019
AbstractCatalpol, an iridoid glycoside, is an isolated natural product of Rehmannia glutinosa, which has been reported to have antidiabetic properties. This study investigated the vascular protective effects of catalpol in hyperglycemic rats with balloon-injured carotid arteries. Balloon injury stress led to the upregulation of monocyte chemoattractant
Chiu-Mei, Lin, Bao-Wei, Wang, Wei-Jen, Fang, Chun-Ming, Pan, Kou-Gi, Shyu, Sheng-Wen, Hou   +5 more
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Amelioration by Catalpol of Atherosclerotic Lesions in Hypercholesterolemic Rabbits

Planta Medica, 2015
The aim of the present study was to evaluate the effects of catalpol administration on atherosclerosis. Atherogenesis was induced by a high-cholesterol chow in male New Zealand White rabbits that were randomly assigned to receive atorvastatin (5 mg/kg/day), catalpol (5 mg/kg/day), or vehicle by oral gavage for 12 weeks.
Jiang-yue, Liu, Dai-juan, Zhang
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Neuroprotection of catalpol in transient global ischemia in gerbils

Neuroscience Research, 2004
The neuroprotection of catalpol and its mechanism was evaluated in cerebral ischemic model in gerbils. Three groups were designed as sham-operated, ischemia-treated, respectively, with catalpol and saline. Catalpol was injected intraperitoneally immediately after reperfusion and repeatedly at 12, 24, 48 and 72 h with the dose of 5.0 mg/kg.
Dan-Qing, Li, Yan-Long, Duan, Yong-Ming, Bao, Chui-Ping, Liu, Ying, Liu, Li-Jia, An   +5 more
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Iridoids: An efficient conversion of (−)-catalpol into (−)-specionin

Tetrahedron Letters, 1987
Abstract A partial synthesis of the antifeedant (−)-specionin ( 8 ) starting from the readily available (−)-catalpol ( 1 ) is described. It also allows the formation of analogs of 8 via specific transformations on intermediates 3 or 5 for screening of antifeedant properties.
E. Van der Eycken, A. Janssens, M. Vandewalle   +2 more
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The significance of the iridoid glycoside, catalpol, in Scutellaria

Biochemical Systematics and Ecology, 1991
Abstract The distribution of catalpol and derivatives in Scutellaria species has been investigated in the light of a recent, novel, infrageneric classification of the genus, and found to provide support for the new classification.
Michael D. Cole, Alan J. Paton, Ray M. Harleyl, Linda E. Fellows   +3 more
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Oral supplementation of catalpol ameliorates diabetic encephalopathy in rats

Brain Research, 2010
Diabetes mellitus can cause dysfunction of the central nervous system called "diabetic encephalopathy." Although insulin and various oral drugs are used to treat diabetes, they do not completely prevent the development of diabetic encephalopathy, and novel strategies for the prevention and treatment are urgently needed.
Cheng-Fang, Wang, Dan-Qing, Li, Hong-Yu, Xue, Bo, Hu   +3 more
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Antihyperglycemic Effect of Catalpol in Streptozotocin-Induced Diabetic Rats

Journal of Natural Products, 2010
The antihyperglycemic effect of catalpol (1) purified from the roots of Rehmannia glutinosa was investigated in streptozotocin-induced diabetic rats (STZ-diabetic rats) representing insulin-dependent diabetes mellitus. Bolus intravenous injection of 1 showed antihyperglycemic activity in a dose-dependent manner in STZ-diabetic rats.
Wei-Jan, Huang, Ho-Shan, Niu, Mei-Hsiang, Lin, Juei-Tang, Cheng, Fen-Lin, Hsu   +4 more
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Neuroprotective activities of catalpol on MPP+/MPTP-induced neurotoxicity

Neurological Research, 2008
Catalpol is an iridoid glycoside, distributed in the roots of Rehmannia glutinosa Libosch. In vitro results showed that preincubation with catalpol (0.5-0.5 mM) for 0.5 hours before and during 48 hour exposure to 0.2 mM MPP+ appeared to be significant protective effect while catalopl was considerably less effective at the doses of 0.001 to 0.01 mM. The
Bo, Jiang, Huang, Zhang, Jing, Bi, Xiu Li, Zhang   +3 more
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Chloroquine enhances catalpol's ability to promote apoptosis by inhibiting catalpol's autophagy-promoting effect on gastric cancer.

Journal of B.U.ON. : official journal of the Balkan Union of Oncology, 2021
Gastric cancer, which is derived from gastric mucosal epithelial cells, is a representative solid tumour, and more than 1 million cases are diagnosed worldwide each year. However, treatment methods and therapeutics for gastric cancer are limited, and further research is needed to develop novel strategies.In this experiment, we studied the effect of ...
Fangzheng, Sun, Zhenghua, Wang, Xiaoyu, Wang   +2 more
openaire   +1 more source

Effects of Catalpol from Rehmannia glutinosa Extract on Skin Flaps

Plastic & Reconstructive Surgery, 2023
Background: Flaps are commonly used for repairing tissues and wounds in surgery. However, various factors can cause postoperative necrosis in these flaps. Catalpol is a bioactive component in extracts from Rehmannia glutinosa, which has pharmacologic characteristics that may improve flap survival.
Xinyi, Ma, Yi, Lin, Miaojie, Fang, Yingying, Liu, Wenjie, Li, Jibing, He, Dingsheng, Lin   +6 more
openaire   +2 more sources