Results 141 to 150 of about 1,785 (172)

Effects of catalpol on bronchial asthma and its relationship with cytokines

Journal of Cellular Biochemistry, 2018
AbstractAn animal (BALB/c mice) model of catalpol associated with bronchial asthma in vivo was established, and the effects of catalpol and its relationship with cytokines were investigated. A total of 30 adult BALB/c mice were randomly divided into a positive control group, a model group, and a catalpol group, with 10 mice in each group.
Yanlin Li, Hai Wang, Xu Yang
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The anti-aging mechanisms of Catalpol by elevating mitophagy

Gene
Autophagy is an important mechanism for maintaining cell homeostasis, and its decline in function is widely regarded as a key factor in aging. Catalpol (CAT), an active compound derived from the traditional Chinese herbRehmannia glutinosa, has shown potential to treat various age-related diseases through the regulation of autophagy.
Songtao Bie, Ze Yao, Ming Lu, Chunshuang Li, Xiang Li, Hui Shang   +5 more
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Anti‐inflammatory effect and mechanism of catalpol in various inflammatory diseases

Drug Development Research, 2023
AbstractCatalpol is a kind of iridoid glucoside, widely found in a variety of plants, mostly extracted from the rhizome of the traditional medicinal herb rehmanniae. It has various biological activities such as anti‐inflammatory, antioxidant, and antitumor.
Jinyao Liu, Shuang Liu, Mingyue Yu, Jianing Li, Zunxuan Xie, Boyang Gao, Yuyan Liu   +6 more
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In silico study of the inhibition of DNA polymerase by a novel catalpol derivative

Journal of Molecular Modeling, 2011
In this work, a novel catalpol derivative (6,10,2',6'-tetraacetyl-O-catalpol), which was previously obtained by our group and shown experimentally to inhibit a type of Taq DNA polymerase, was studied in silico. Studies of the interaction of 6,10,2',6'-tetraacetyl-O-catalpol with the Klentaq fragment of the Taq DNA polymerase I from Thermus aquaticus ...
Martín, Osvaldo Antonio, Garro, Hugo Alejandro, Kurina Sanz, Marcela Beatriz, Tonn, Carlos Eugenio, Pungitore, Carlos Rodolfo   +4 more
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Novel antiproliferative analogs of the Taq DNA polymerase inhibitor catalpol

Bioorganic & Medicinal Chemistry Letters, 2007
The naturally occurring iridoid catalpol (1) is a Taq DNA polymerase inhibitor. However, its poor lipophilicity might account for the lack of biological activity against human solid tumor cell lines. The traditional prodrug approach by means of peracetylation of the free hydroxyl groups led to a compound, which showed a marginal growth inhibition ...
Carlos R, Pungitore, Leticia G, León, Celina, García, Víctor S, Martín, Carlos E, Tonn, José M, Padrón   +5 more
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Borneol promotes oral absorption and penetration into brain of puerarin and catalpol

China Journal of Chinese Materia Medica, 2016
To investigate the effect of borneol on the oral absorption and penetration into brain of puerarin and catalpol from cell level and animal level, and screen the concentration of borneol that is suitable for Zige compound oral preparation. Blood-brain barrier(BBB) model was established by co-culture of primary brain microvessel endothelial cells(BMEC ...
Dan-Dan, Tang, Jiao, Zhang, Ji-Rui, Wang, Ji-Fen, Zhang, Xiao-Yu, Xu   +4 more
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Effects of catalpol on the activity of human liver cytochrome P450 enzymes

Xenobiotica, 2019
1. Catalpol possesses numerous pharmacological activities, and however, little data available for the effects of catalpol on the activity of human liver cytochrome P450 (CYP) enzymes. 2. This study investigates the inhibitory effects of catalpol on the main human liver CYP isoforms.
Lu, Liu, Xiangang, Cao, Tingxin, Li, Xiaohua, Li   +3 more
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Secretion of catalpol from Rehmannia glutinosa roots to the rhizosphere

Acta Physiologiae Plantarum, 2009
The concentrations of catalpol in the culture solutions, roots, stems and leaves of Rehmannia glutinosa Libosch. were determined by HPLC. The biological activity of catalpol was detected with Arabidopsis thaliana L. seedlings. The results showed that all R. glutinosa Libosch. vegetative organs contained catalpol.
Taixia Wang, Mengyuan Gui, Hexia Liu, Hongyan Zhao, Ling Xu, Min Zha, Jingyuan Li   +6 more
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[Advances in research on pharmacodynamics and chemical conversion of catalpol].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2008
Catalpol is a active component in Rehmannia Root, and its pharmacological effects are extensive. In this paper its effects and chemical changes were summarized. This will offer the reference for further research work catalpol.
Yan-fei, Liu, Yu, Zhao, Xue-sen, Wen, Qi-ting, Dong   +3 more
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Structure of catalpol hexaacetate

Acta Crystallographica Section C Crystal Structure Communications, 1989
M. Jiménez E., M. A. González G., A. Lira-Rocha, R. A. Toscano, M. Soriano-García   +4 more
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