Results 171 to 180 of about 3,043 (217)

Biosynthesis of catalpol

Phytochemistry, 1994
Abstract Feeding experiments with deuterium-labelled 8- epi -deoxyloganic acid, bartsioside and aucubin gave incorporation of all compounds into catalpol both in Scutellaria albida and Paulownia tomentosa . Dilution experiments with labelled 8- epi -deoxyloganic acid and unlabelled aucubin showed that aucubin is an intermediate in the biosynthesis
Søren Damtoft
exaly   +2 more sources

Catalpol promotes mitochondrial biogenesis in chondrocytes

Archives of Physiology and Biochemistry, 2020
The chondrocyte mitochondrial dysfunction has been considered to be associated with the pathogenesis of joint diseases. Catalpol is an active traditional Chinese medicine ingredient named Di-Huang, which is used widely to treat different diseases.
Dan, Chen, Jing, Guo, Longguang, Li
openaire   +2 more sources

Protective effects of catalpol on cardio-cerebrovascular diseases: A comprehensive review

Journal of Pharmaceutical Analysis, 2023
Catalpol, an iridoid glucoside isolated from Rehmannia glutinosa, has gained attention due to its potential use in treating cardio-cerebrovascular diseases (CVDs). This extensive review delves into recent studies on catalpol's protective properties in relation to various CVDs, such as atherosclerosis, myocardial ischemia, infarction, cardiac ...
Zixi Zhang, Yongguo Dai, Qiming Liu
exaly   +4 more sources

Catalpol: A Potential Therapeutic for Neurodegenerative Diseases

Current Medicinal Chemistry, 2015
Neurodegenerative disorders, e.g., Alzheimer's disease (AD) and Parkinson's disease (PD) are characterized by the progressive loss of neurons and subsequent cognitive decline. They are mainly found in older populations. Due to increasing life expectancies, the toll inflicted upon society by these disorders continues to become heavier and more prominent.
B, Jiang, R F, Shen, J, Bi, X S, Tian, T, Hinchliffe, Y, Xia   +5 more
openaire   +2 more sources

Study on the inhibitive effect of Catalpol on diabetic nephropathy

Life Sciences, 2020
Catalpol (Cat) can ameliorate oxide stress and inflammation caused by diabetic nephropathy (DN), but the molecular mechanisms are unclear. This study was designed to investigate the anti-diabetic effects of Cat and its potential mechanism.We constructed high-fat diet/streptozotocin (HFD/STZ)-induced DN mice and high glucose (HG)-induced podocyte model.
Jing Chen, Yuwei Yang, Zhiyang Lv, Anmei Shu, Qiu Du, Wei Wang, Yuping Chen, Huiqin Xu   +7 more
openaire   +2 more sources

Effect of catalpol on diabetic nephropathy in rats

Phytomedicine, 2013
To investigate the effect of catalpol on diabetic nephropathy in rats.Male Sprague-Dawley rats were randomly divided into two groups and fed with normal pallet diet (NPD) or high-fat diet (HFD) for 4 weeks respectively. Then the HFD-fed rats were injected with 35 mg/kg streptozotocin (STZ) for establishing diabetic model.
Zhao, Dong, Chang Xun, Chen
openaire   +2 more sources

Catalpol Ameliorates Neointimal Hyperplasia in Diabetic Rats

Planta Medica, 2019
AbstractCatalpol, an iridoid glycoside, is an isolated natural product of Rehmannia glutinosa, which has been reported to have antidiabetic properties. This study investigated the vascular protective effects of catalpol in hyperglycemic rats with balloon-injured carotid arteries. Balloon injury stress led to the upregulation of monocyte chemoattractant
Chiu-Mei, Lin, Bao-Wei, Wang, Wei-Jen, Fang, Chun-Ming, Pan, Kou-Gi, Shyu, Sheng-Wen, Hou   +5 more
openaire   +2 more sources

Amelioration by Catalpol of Atherosclerotic Lesions in Hypercholesterolemic Rabbits

Planta Medica, 2015
The aim of the present study was to evaluate the effects of catalpol administration on atherosclerosis. Atherogenesis was induced by a high-cholesterol chow in male New Zealand White rabbits that were randomly assigned to receive atorvastatin (5 mg/kg/day), catalpol (5 mg/kg/day), or vehicle by oral gavage for 12 weeks.
Jiang-yue, Liu, Dai-juan, Zhang
openaire   +2 more sources

Neuroprotection of catalpol in transient global ischemia in gerbils

Neuroscience Research, 2004
The neuroprotection of catalpol and its mechanism was evaluated in cerebral ischemic model in gerbils. Three groups were designed as sham-operated, ischemia-treated, respectively, with catalpol and saline. Catalpol was injected intraperitoneally immediately after reperfusion and repeatedly at 12, 24, 48 and 72 h with the dose of 5.0 mg/kg.
Dan-Qing, Li, Yan-Long, Duan, Yong-Ming, Bao, Chui-Ping, Liu, Ying, Liu, Li-Jia, An   +5 more
openaire   +2 more sources

Iridoids: An efficient conversion of (−)-catalpol into (−)-specionin

Tetrahedron Letters, 1987
Abstract A partial synthesis of the antifeedant (−)-specionin ( 8 ) starting from the readily available (−)-catalpol ( 1 ) is described. It also allows the formation of analogs of 8 via specific transformations on intermediates 3 or 5 for screening of antifeedant properties.
E. Van der Eycken, A. Janssens, M. Vandewalle   +2 more
openaire   +1 more source