Results 181 to 190 of about 3,043 (217)

Neuroprotective activities of catalpol on MPP+/MPTP-induced neurotoxicity

Neurological Research, 2008
Catalpol is an iridoid glycoside, distributed in the roots of Rehmannia glutinosa Libosch. In vitro results showed that preincubation with catalpol (0.5-0.5 mM) for 0.5 hours before and during 48 hour exposure to 0.2 mM MPP+ appeared to be significant protective effect while catalopl was considerably less effective at the doses of 0.001 to 0.01 mM. The
Bo, Jiang, Huang, Zhang, Jing, Bi, Xiu Li, Zhang   +3 more
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Oral supplementation of catalpol ameliorates diabetic encephalopathy in rats

Brain Research, 2010
Diabetes mellitus can cause dysfunction of the central nervous system called "diabetic encephalopathy." Although insulin and various oral drugs are used to treat diabetes, they do not completely prevent the development of diabetic encephalopathy, and novel strategies for the prevention and treatment are urgently needed.
Cheng-Fang, Wang, Dan-Qing, Li, Hong-Yu, Xue, Bo, Hu   +3 more
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Effects of Catalpol from Rehmannia glutinosa Extract on Skin Flaps

Plastic & Reconstructive Surgery, 2023
Background: Flaps are commonly used for repairing tissues and wounds in surgery. However, various factors can cause postoperative necrosis in these flaps. Catalpol is a bioactive component in extracts from Rehmannia glutinosa, which has pharmacologic characteristics that may improve flap survival.
Xinyi, Ma, Yi, Lin, Miaojie, Fang, Yingying, Liu, Wenjie, Li, Jibing, He, Dingsheng, Lin   +6 more
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Chloroquine enhances catalpol's ability to promote apoptosis by inhibiting catalpol's autophagy-promoting effect on gastric cancer.

Journal of B.U.ON. : official journal of the Balkan Union of Oncology, 2021
Gastric cancer, which is derived from gastric mucosal epithelial cells, is a representative solid tumour, and more than 1 million cases are diagnosed worldwide each year. However, treatment methods and therapeutics for gastric cancer are limited, and further research is needed to develop novel strategies.In this experiment, we studied the effect of ...
Fangzheng, Sun, Zhenghua, Wang, Xiaoyu, Wang   +2 more
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The significance of the iridoid glycoside, catalpol, in Scutellaria

Biochemical Systematics and Ecology, 1991
Abstract The distribution of catalpol and derivatives in Scutellaria species has been investigated in the light of a recent, novel, infrageneric classification of the genus, and found to provide support for the new classification.
Michael D. Cole, Alan J. Paton, Ray M. Harleyl, Linda E. Fellows   +3 more
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Antihyperglycemic Effect of Catalpol in Streptozotocin-Induced Diabetic Rats

Journal of Natural Products, 2010
The antihyperglycemic effect of catalpol (1) purified from the roots of Rehmannia glutinosa was investigated in streptozotocin-induced diabetic rats (STZ-diabetic rats) representing insulin-dependent diabetes mellitus. Bolus intravenous injection of 1 showed antihyperglycemic activity in a dose-dependent manner in STZ-diabetic rats.
Wei-Jan, Huang, Ho-Shan, Niu, Mei-Hsiang, Lin, Juei-Tang, Cheng, Fen-Lin, Hsu   +4 more
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Effects of catalpol on bronchial asthma and its relationship with cytokines

Journal of Cellular Biochemistry, 2018
AbstractAn animal (BALB/c mice) model of catalpol associated with bronchial asthma in vivo was established, and the effects of catalpol and its relationship with cytokines were investigated. A total of 30 adult BALB/c mice were randomly divided into a positive control group, a model group, and a catalpol group, with 10 mice in each group.
Yanlin Li, Hai Wang, Xu Yang
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Anti‐inflammatory effect and mechanism of catalpol in various inflammatory diseases

Drug Development Research, 2023
AbstractCatalpol is a kind of iridoid glucoside, widely found in a variety of plants, mostly extracted from the rhizome of the traditional medicinal herb rehmanniae. It has various biological activities such as anti‐inflammatory, antioxidant, and antitumor.
Jinyao Liu, Shuang Liu, Mingyue Yu, Jianing Li, Zunxuan Xie, Boyang Gao, Yuyan Liu   +6 more
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The anti-aging mechanisms of Catalpol by elevating mitophagy

Gene
Autophagy is an important mechanism for maintaining cell homeostasis, and its decline in function is widely regarded as a key factor in aging. Catalpol (CAT), an active compound derived from the traditional Chinese herbRehmannia glutinosa, has shown potential to treat various age-related diseases through the regulation of autophagy.
Songtao Bie, Ze Yao, Ming Lu, Chunshuang Li, Xiang Li, Hui Shang   +5 more
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In silico study of the inhibition of DNA polymerase by a novel catalpol derivative

Journal of Molecular Modeling, 2011
In this work, a novel catalpol derivative (6,10,2',6'-tetraacetyl-O-catalpol), which was previously obtained by our group and shown experimentally to inhibit a type of Taq DNA polymerase, was studied in silico. Studies of the interaction of 6,10,2',6'-tetraacetyl-O-catalpol with the Klentaq fragment of the Taq DNA polymerase I from Thermus aquaticus ...
Martín, Osvaldo Antonio, Garro, Hugo Alejandro, Kurina Sanz, Marcela Beatriz, Tonn, Carlos Eugenio, Pungitore, Carlos Rodolfo   +4 more
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