Results 91 to 100 of about 705,088 (330)
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Raphin‐1 reduces the survival of PED‐DHGG cells and enhances their radiation sensitivity through both PeIF2α‐dependent and PeIF2α‐independent mechanisms. Raphin‐1 sustains elevated levels of PeIF2α, contributing to its PeIF2α‐dependent effects. Additionally, raphin‐1 interacts with CReP to mediate a separate radiosensitizing pathway that operates ...
Karin Eytan +4 more
wiley +1 more source
Molecular Oncology, EarlyView.In prostate carcinoma, lactic acid, secreted by highly glycolytic cancer‐associated fibroblasts, is imported into tumor cells through the MCT1 transporter and prevents RSL3 and erastin‐induced ferroptosis (A). Targeting of carbonic anhydrase IX/XII, the main extracellular pH regulators, in tumor and stromal cells reduces microenvironmental acidosis and
Elisa Pardella +18 more
wiley +1 more source
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2006 Carrier linked solute transport through biomembranes is analysed with the viewpoint of catalysis. Different from enzymes, in carriers the unchanged substrate induces optimum fit in the transition state. The enhanced intrinsic binding energy pays for the energy required of the global conformation changes, thus decreasing the activation energy barrier ...
openaire +2 more sources
COMBUSTION OF MODEL AND REAL OIL SLUDGE IN A FLUIDIZED BED OF CATALYST
Известия Томского политехнического университета: Инжиниринг георесурсов, 2019 The relevance of the research is caused by generation of a huge amount of oil refinery waste (mainly oil sludge and acid tars). The development of technologies for processing such type of raw materials is an important area for many research teams ...
Yury V. Dubinin +3 more
doaj +1 more source
Molecular Oncology, EarlyView.A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira +14 more
wiley +1 more source
FEBS Open Bio, EarlyView.d‐Allulose can be produced from d‐fructose by d‐allulose 3‐epimerase. Based on sequence homology information, we successfully engineered thermostable mutants with the protein engineering method. By integrating positive mutations, we constructed an enzyme that exhibits hyperthermostability without a loss in the activity.
Kensaku Shimada +3 more
wiley +1 more source
Energies, 2019 The effect of nitrogen doped bamboo-like carbon nanotubes (N−CNTs) on the properties of supported platinum (0.2 and 1 wt %) catalysts in formic acid decomposition for hydrogen production was studied.
Olga Podyacheva +8 more
doaj +1 more source
Boron carboxylate catalysis of homoallylboration. [PDF]
, 2014 Boron tris(trifluoroacetate) is identified as the first effective catalyst for the homoallyl- and homocrotylboration of aldehydes by cyclopropylcarbinylboronates.
Dugas, Gabrielle J +3 more
core
Chiral transition in dense, magnetized matter
, 2012 In the presence of a chemical potential, the effect of a magnetic field on chiral symmetry breaking goes beyond the well-known magnetic catalysis. Due to a subtle interplay with the chemical potential, the magnetic field may work not only in favor but ...
Preis, Florian +2 more
core +2 more sources