Results 11 to 20 of about 9,873 (264)

Narcolepsy: Pathophysiology, Diagnosis, Management, and Future Directions, a Narrative Review. [PDF]

Brain Behav
This visual summary outlines the pathophysiology of narcolepsy, driven by hypocretin loss, and details its clinical diagnosis, current management strategies, and the shift toward future disease‐modifying therapies like orexin agonists and immunomodulation.
Hastings NE, Abdi KE, Bibi F, Aslam B, Nuñez MR, Sherani MTR, Shadmani S, Alam U, Hassan VM, Hoor-E-Ainaa, Imran H, Hanna J, Sadat SH.   +12 more
europepmc   +2 more sources

Narcolepsy 2025 (with an Australasian perspective). [PDF]

Intern Med J
Abstract Narcolepsy is a disorder of central hypersomnolence, which, while uncommon, can carry profound implications for affected individuals. Despite this, it remains under‐recognised within the medical community and presents frequent diagnostic and treatment challenges in the Australasian setting.
Lin A, Yee BJ, Tai JE, Sivam S.
europepmc   +2 more sources

Orexin Deficiency in Narcolepsy: Molecular Mechanisms, Clinical Phenotypes, and Emerging Therapeutic Frontiers. [PDF]

Brain Behav
Orexin deficiency drives narcolepsy Type 1, leading to excessive daytime sleepiness, cataplexy, and REM intrusions. This review highlights recent advances (2023–2025) in molecular mechanisms, diagnostics, and emerging orexin‐targeted therapies with the potential for disease modification.
Rauf R, Asif S, AlSaafeen A, Dhantapaani KG, Nadeem MM, Rao ZK, Hameed ASS, Chintharala K, Anwar MF, Cheema AAA.   +9 more
europepmc   +2 more sources

Dopamine release in the nucleus accumbens promotes REM sleep and cataplexy

iScience, 2023
Summary: Patients with the sleep disorder narcolepsy suffer from excessive daytime sleepiness, disrupted nighttime sleep, and cataplexy—the abrupt loss of postural muscle tone during wakefulness, often triggered by strong emotion.
Brandon A. Toth, Katie S. Chang, Sarah Fechtali, Christian R. Burgess   +3 more
doaj   +1 more source

Positive memory increases cataplexy-like behaviors in narcolepsy mice as revealed using conditioned place preference test

BMC Neuroscience, 2022
Background Cataplexy is a loss of muscle tone that can lead to postural collapse, disturbing the daily life of narcolepsy patients; it is often triggered by positive emotions such as laughter in human patients.
Mayuko Yoshida, Koki Yamamoto, Tomoyuki Kuwaki   +2 more
doaj   +1 more source

How are normal sleeping controls selected? A systematic review of cross-sectional insomnia studies, and a standardised method to select healthy controls for sleep research [PDF]

, 2008
There appears to be some inconsistency in how normal sleepers (controls) are selected and screened for participation in research studies for comparison with insomnia patients.
Louise Beattie, Colin A. Espie, Simon D. Kyle, Stephany M. Biello, Luyster, Edinger, Heffner, American Sleep Disorders Association, Buysse, Bastien, Ong, Bower, Ree, Barclay, Jones, Horne, Archer, Goel, Taillard, Phipps-Nelson, Carney, Vandewalle, Yoo, Ferguson, Buysse, Dahlgren, Carney, Buysse, Espie, Espie, Lund, Yiend, Espie, Harvey, Harvey, Kyle, Ellis, Ohayon, Barclay, Monk, Barclay, Monk, Wittmann, Roenneberg, Spiegel, Kyle, Lineberger, Wilson, Doghamji, Douglass, Baumann, Espie, Buysse, Meerlo, Kripke, Vgontzas, Kaplan, Van Dongen, Monk, Drake   +59 more
core   +15 more sources

Activity of putative orexin neurons during cataplexy

Molecular Brain, 2022
It is unclear why orexin-deficient animals, but not wild-type mice, show cataplexy. The current hypothesis predicts simultaneous excitation of cataplexy-inhibiting orexin neurons and cataplexy-inducing amygdala neurons.
Shi Zhou, Akira Yamashita, Jingyang Su, Yang Zhang, Wuyang Wang, Liying Hao, Akihiro Yamanaka, Tomoyuki Kuwaki   +7 more
doaj   +1 more source

Increased immune complexes of hypocretin autoantibodies in narcolepsy. [PDF]

PLoS ONE, 2010
BACKGROUND: Hypocretin peptides participate in the regulation of sleep-wake cycle while deficiency in hypocretin signaling and loss of hypocretin neurons are causative for narcolepsy-cataplexy.
Aude Deloumeau, Sophie Bayard, Quentin Coquerel, Pierre Déchelotte, Christine Bole-Feysot, Bertrand Carlander, Valérie Cochen De Cock, Sergueï O Fetissov, Yves Dauvilliers   +8 more
doaj   +1 more source

Clinical, polysomnographic and genome‐wide association analyses of narcolepsy with cataplexy: a European Narcolepsy Network study

Journal of Sleep Research, 2013
yves Dauvilliers, Sebastiaan Overeem, Rosa Peraita-Adrados   +2 more
exaly   +3 more sources

Clinical and Polysomnographic Comparison between Narcolepsy without Cataplexy and Idiopathic Hypersomnia [PDF]

Sleep Medicine Research, 2012
Background and Objective The aim of this study is to compare the clinical, electrophysiological (Polysomnography, PSG; Multiple Sleep Latency Test, MSLT) and biological data (HLA DQB1*0602 typing) in idiopathic hypersomnia with narcolepsy without ...
Tae Won Kim, Se Yeon Chang, Soo Hyun Joo, Ho Jun Seo, Jong Hyun Jeong, Jin Hee Han, Emmanuel Mignot, Seung Chul Hong   +7 more
doaj   +1 more source