Results 11 to 20 of about 8,702 (224)

Hypocretinergic interactions with the serotonergic system regulate REM sleep and cataplexy

Nature Communications, 2020
Narcolepsy is characterized by a sudden loss of muscle tone (cataplexy) similar to REM sleep and is caused by hypocretin deficiency. Here, the authors show that deleting the serotonin transporter gene in hypocretin knockout mice suppresses cataplexy ...
Ali Seifinejad, Marie-Laure Possovre, Anne Vassalli   +2 more
exaly   +2 more sources

Case Report: Narcolepsy patients masked behind obstructive sleep apnea syndrome (OSAS): report of 2 cases and literature review [PDF]

Frontiers in Neuroscience
Obstructive sleep apnea syndrome (OSAS) and narcolepsy are sleep disorders that commonly present with excessive daytime sleepiness (EDS). OSAS is characterized by recurrent upper airway obstruction during sleep, leading to intermittent hypoxia and sleep ...
Simin Zou, Xiaomei Zhang, Yinping Shen, Zhongxia Shen, Zhong Wang, Benhong Wang   +5 more
doaj   +2 more sources

Narcolepsy in early childhood: a case report and a Mini review [PDF]

Frontiers in Pediatrics
Narcolepsy is a sleep-wake disorder with an onset commonly seen in individuals aged 10–30 years. Due to various reasons, the diagnosis of narcolepsy often experiences a delay of at least ten years.
Guorui Liu, Guorui Liu, Guanxiong Li, Yihao Wang, Ming Yin, Wen Pan, Yu Zhao, Shigeng Gao, Peiqi Shi, Jing Wen, Xiao Pan, Yajing Wang, Yanfei Zhang   +12 more
doaj   +2 more sources

Narcolepsy: Pathophysiology, Diagnosis, Management, and Future Directions, a Narrative Review. [PDF]

Brain Behav
This visual summary outlines the pathophysiology of narcolepsy, driven by hypocretin loss, and details its clinical diagnosis, current management strategies, and the shift toward future disease‐modifying therapies like orexin agonists and immunomodulation.
Hastings NE, Abdi KE, Bibi F, Aslam B, Nuñez MR, Sherani MTR, Shadmani S, Alam U, Hassan VM, Hoor-E-Ainaa, Imran H, Hanna J, Sadat SH.   +12 more
europepmc   +2 more sources

Once-Nightly Sodium Oxybate Meets American Academy of Sleep Medicine Criteria for Treatment of Narcolepsy. [PDF]

J Sleep Res
ABSTRACT Data from the REST‐ON trial were not available before the 2021 American Academy of Sleep Medicine (AASM) clinical practice guideline update, which included a literature review through August 2020. This post hoc analysis from REST‐ON assessed participants who achieved clinically significant improvements on individual AASM clinical significance ...
Ortiz LE, Morse AM, Thorpy MJ, Kushida CA, Harsh J, Roth T, Gudeman J, Dauvilliers Y.   +7 more
europepmc   +2 more sources

Dopamine release in the nucleus accumbens promotes REM sleep and cataplexy

iScience, 2023
Summary: Patients with the sleep disorder narcolepsy suffer from excessive daytime sleepiness, disrupted nighttime sleep, and cataplexy—the abrupt loss of postural muscle tone during wakefulness, often triggered by strong emotion.
Brandon A. Toth, Katie S. Chang, Sarah Fechtali, Christian R. Burgess   +3 more
doaj   +1 more source

Positive memory increases cataplexy-like behaviors in narcolepsy mice as revealed using conditioned place preference test

BMC Neuroscience, 2022
Background Cataplexy is a loss of muscle tone that can lead to postural collapse, disturbing the daily life of narcolepsy patients; it is often triggered by positive emotions such as laughter in human patients.
Mayuko Yoshida, Koki Yamamoto, Tomoyuki Kuwaki   +2 more
doaj   +1 more source

How are normal sleeping controls selected? A systematic review of cross-sectional insomnia studies, and a standardised method to select healthy controls for sleep research [PDF]

, 2008
There appears to be some inconsistency in how normal sleepers (controls) are selected and screened for participation in research studies for comparison with insomnia patients.
Louise Beattie, Colin A. Espie, Simon D. Kyle, Stephany M. Biello, Luyster, Edinger, Heffner, American Sleep Disorders Association, Buysse, Bastien, Ong, Bower, Ree, Barclay, Jones, Horne, Archer, Goel, Taillard, Phipps-Nelson, Carney, Vandewalle, Yoo, Ferguson, Buysse, Dahlgren, Carney, Buysse, Espie, Espie, Lund, Yiend, Espie, Harvey, Harvey, Kyle, Ellis, Ohayon, Barclay, Monk, Barclay, Monk, Wittmann, Roenneberg, Spiegel, Kyle, Lineberger, Wilson, Doghamji, Douglass, Baumann, Espie, Buysse, Meerlo, Kripke, Vgontzas, Kaplan, Van Dongen, Monk, Drake   +59 more
core   +15 more sources

Activity of putative orexin neurons during cataplexy

Molecular Brain, 2022
It is unclear why orexin-deficient animals, but not wild-type mice, show cataplexy. The current hypothesis predicts simultaneous excitation of cataplexy-inhibiting orexin neurons and cataplexy-inducing amygdala neurons.
Shi Zhou, Akira Yamashita, Jingyang Su, Yang Zhang, Wuyang Wang, Liying Hao, Akihiro Yamanaka, Tomoyuki Kuwaki   +7 more
doaj   +1 more source

Increased immune complexes of hypocretin autoantibodies in narcolepsy. [PDF]

PLoS ONE, 2010
BACKGROUND: Hypocretin peptides participate in the regulation of sleep-wake cycle while deficiency in hypocretin signaling and loss of hypocretin neurons are causative for narcolepsy-cataplexy.
Aude Deloumeau, Sophie Bayard, Quentin Coquerel, Pierre Déchelotte, Christine Bole-Feysot, Bertrand Carlander, Valérie Cochen De Cock, Sergueï O Fetissov, Yves Dauvilliers   +8 more
doaj   +1 more source