Results 71 to 80 of about 8,702 (224)
Narcolepsy, cataplexy, hypocretin and co-existing other health complaints: A review
Cogent Medicine, 2017 The presence of cataplexy in people with narcolepsy has a well-documented tight association with very low or non-detectable levels of the central nervous system neuropeptide, hypocretin (also termed orexin) while levels of hypocretin are normal in people
Samantha Gauci +2 more
doaj +1 more source
Facial Emotion Recognition in Children With Narcolepsy Type 1
Journal of Sleep Research, Volume 35, Issue 2, April 2026.ABSTRACT Narcolepsy type 1 is a neurological disorder typically emerging in childhood or adolescence, characterised by excessive daytime sleepiness, cataplexy and rapid eye movement sleep‐related symptoms. Beyond its core features, increasing evidence suggests an impact on socio‐cognitive development, including difficulties in understanding others ...
Marco Veneruso +11 more
wiley +1 more source
Narcolepsy and Cataplexy – a practical approach to diagnosis and managing the impact of this chronic condition on children and their families [PDF]
, 2017 Narcolepsy is a relatively common neurological condition affecting the regulation of normal sleep/wake cycles leading to excessive daytime sleepiness (EDS).
Blackwell, J +3 more
core +1 more source
Ambulatory video-EEG-EMG monitoring and analysis during cataplexy in narcolepsy
Chinese Journal of Contemporary Neurology and Neurosurgery, 2017 Objective To comprehensively analyze the clinical and electroneurophysiological characteristics during the process of cataplexy by dynamic video?EEG?EMG monitoring.
Bei HUANG +4 more
doaj
Psychiatry and Clinical Psychopharmacology, 2018 Giggle incontinence (GI) is characterized by involuntary and generally unpredictable release of urine during giggling or laughter. It has been suggested that GI may be a centrally mediated disorder and may share a common pathophysiology with narcolepsy ...
İsmail Akaltun +2 more
doaj +1 more source
Wake‐promoting neuromodulators in Alzheimer's disease: Implications for sleep and brain clearance
Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.Abstract Neuromodulatory subcortical systems (NSS) regulate arousal, cognition, and sleep–wake transitions through widespread influence on cortical and subcortical networks. Increasing evidence links dysfunction of these systems to the pathogenesis of Alzheimer's disease (AD). Degeneration and dysregulation of NSS occurs during the preclinical phase of
Taylor J. Pedersen +7 more
wiley +1 more source
Selective loss of GABAB receptors in orexin/hypocretin-producing neurons results in disrupted sleep/wakefulness architecture [PDF]
, 2007 We generated mice with a selective loss of GABAB receptors in orexin neurons. Orexin neurons in these GABAB1<sup>-/-(orexin)</sup> mice showed reduced responsiveness to GABA<sub>A</sub> receptor agonists due to a ...
Bernard Bettler +10 more
core +1 more source
Sleep disorders and sleep behaviors as predictors of neurodegenerative diseases
Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.Abstract INTRODUCTION The impact of sleep disorders (SDs) on incident neurodegenerative disease (NDD) risk has not been comprehensively investigated. METHODS In the UK Biobank cohort, 30,032 participants with SDs (defined by diagnostic codes) and 147,321 without SDs were included.
Taewon Kim +7 more
wiley +1 more source
Abnormal activity in hypothalamus and amygdala during humour processing in human narcolepsy with cataplexy [PDF]
, 2017 Narcolepsy with cataplexy (NC) is a complex sleep-wake disorder, which was recently found to be associated with a reduction or loss of hypocretin (HCRT, also called orexin). HCRT is a hypothalamic peptide implicated in the regulation of sleep/wake, motor
Bassetti, C L. +6 more
core
Neuropsychopharmacology Reports, Volume 46, Issue 1, March 2026.A 12‐year‐old girl with Klein‐Levin syndrome showed central hypopneas and REM sleep without atonia on 24‐h polysomnography, which normalized after clarithromycin treatment alongside clinical remission. ABSTRACT Kleine–Levin syndrome (KLS) is a rare disorder with limited literature on treatment options and efficacy, especially in adolescents.
Sarisa Thawongit +2 more
wiley +1 more source