Results 101 to 110 of about 9,368,793 (360)
Molecular Oncology, EarlyView.In this explorative biomarker analysis, we assessed serial sampling of circulating tumor cells (CTCs) with CellSearch in two randomized trials testing immune checkpoint inhibitors (ICIs) in metastatic breast cancer. Our data demonstrate a prognostic potential of CTCs, most apparent 4 weeks into ICI therapy.
Nikolai Kragøe Andresen +13 more
wiley +1 more source
Enriching Laser Powder Bed Fusion Part Data Using Category Theory
Journal of Manufacturing and Materials ProcessingLaser powder bed fusion (LPBF) is a promising metal additive manufacturing technology for producing functional components. However, there are still a lot of obstacles to overcome before this technology is considered mature and trustworthy for wider ...
Yuchu Qin +6 more
doaj +1 more source
Molecular Oncology, EarlyView.This study demonstrates that KRAS and GNAS mutations are more prevalent in patients with resected intraductal papillary mucinous neoplasms (IPMN) compared to those under clinical surveillance. GNAS mutations significantly differ between the two patient cohorts, indicating that their absence may serve as a potential biomarker to support conservative ...
Christine Nitschke +12 more
wiley +1 more source
Molecular Oncology, EarlyView.The authors applied joint/mixed models that predict mortality of trifluridine/tipiracil‐treated metastatic colorectal cancer patients based on circulating tumor DNA (ctDNA) trajectories. Patients at high risk of death could be spared aggressive therapy with the prospect of a higher quality of life in their remaining lifetime, whereas patients with a ...
Matthias Unseld +7 more
wiley +1 more source
Molecular Oncology, EarlyView.MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin +14 more
wiley +1 more source
Architecture, Analysis, and Design of Systems Using Extensions of Category Theory
IEEE Open Journal of Systems EngineeringThe engineering of systems has lacked the scientific and mathematical underpinnings enjoyed by traditional engineering disciplines. Earlier work of the authors formulated advanced mathematical methods for architecture definition and the use of model ...
Charles E. Dickerson +1 more
doaj +1 more source
ANALYSIS OF POSSIBILITIES TO PRESENT FORMALLY THE ELEMENTS OF VIRTUAL EDUCATIONAL SPACE [PDF]
Avtomobilʹnyj Transport (Harʹkov), 2017 For formal representation of virtual educational space elements, the paper considers the topology methods, in particularly the methods for categories and functors theory, allowing for solving semistructured and indeterminate problems and reflecting their
О. Morozova
doaj
A General Framework for the Semantics of Type Theory
, 2019 We propose an abstract notion of a type theory to unify the semantics of various type theories including Martin-L\"{o}f type theory, two-level type theory and cubical type theory.
Uemura, Taichi
core
Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression
Molecular Oncology, EarlyView.Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park +6 more
wiley +1 more source