Results 31 to 40 of about 416,309 (377)

Direct targeting of β‐catenin in the Wnt signaling pathway: Current progress and perspectives

Medicinal research reviews (Print), 2021
Aberrant activation of the Wnt/β‐catenin signaling circuit is associated with cancer recurrence and relapse, cancer invasion and metastasis, and cancer immune evasion.
Zhen Wang, Zilu Li, Haitao Ji
semanticscholar   +1 more source

Receptor and secreted targets of Wnt-1/β-catenin signalling in mouse mammary epithelial cells

BMC Cancer, 2005
Background Deregulation of the Wnt/ β-catenin signal transduction pathway has been implicated in the pathogenesis of tumours in the mammary gland, colon and other tissues.
Enver Tariq, Kenny Paraic A, Ashworth Alan   +2 more
doaj   +1 more source

p120 Catenin-Associated Fer and Fyn Tyrosine Kinases Regulate β-Catenin Tyr-142 Phosphorylation and β-Catenin-α-Catenin Interaction [PDF]

Molecular and Cellular Biology, 2003
beta-Catenin has a key role in the formation of adherens junction through its interactions with E-cadherin and alpha-catenin. We show here that interaction of beta-catenin with alpha-catenin is regulated by the phosphorylation of beta-catenin Tyr-142. This residue can be phosphorylated in vitro by Fer or Fyn tyrosine kinases.
Susana Miravet, Jose Piedra, Jose Piedra, Antonio García de Herreros, Hector G. Palmer, Mireia Duñach, Julio Castaño, Nora Heisterkamp   +7 more
openaire   +4 more sources

β-Catenin is a pH sensor with decreased stability at higher intracellular pH. [PDF]

, 2018
β-Catenin functions as an adherens junction protein for cell-cell adhesion and as a signaling protein. β-catenin function is dependent on its stability, which is regulated by protein-protein interactions that stabilize β-catenin or target it for ...
Aberle, Baumgartner, Bree K. Grillo-Hill, Chairoungdua, Choi, Choi, Cold Spring Harbor Protocols, Dai, Daugherty, Denker, Denker, Diane L. Barber, Endo, Forbes, Forbes, Frantz, Frescas, Grillo-Hill, Ha, Hart, Ismahan Chire, Jobelle Peralta, Katharine A. White, Klaus, Krausova, Lee, Li, Liu, Liu, Mario Esquivel, Megy, Morin, Pai, Parks, Peifer, Peifer, Petherick, Pronobis, Reim, Reshkin, Sadot, Sahai-Hernandez, Schönichen, Sedgwick, Shafique, Simons, Stamos, Stehbens, Ulmschneider, Valenta, Vivian N. Bui, Waghmare, Webb, White, White, Wolff, Wu   +56 more
core   +1 more source

β-Catenin expression is associated with cell invasiveness in pancreatic cancer [PDF]

The Korean Journal of Internal Medicine, 2019
Background/Aims This study was tried to determine the role of β-catenin in invasion in pancreatic cancer. Methods We analyzed cancer invasiveness according to β-catenin expression in pancreatic cancer cell line.
Jin Niang Nan, Ok Ran Kim, Myung Ah Lee
doaj   +1 more source

Acetylation of β-Catenin by p300 Regulates β-Catenin-Tcf4 Interaction [PDF]

Molecular and Cellular Biology, 2004
Lysine acetylation modulates the activities of nonhistone regulatory proteins and plays a critical role in the regulation of cellular gene transcription. In this study, we showed that the transcriptional coactivator p300 acetylated beta-catenin at lysine 345, located in arm repeat 6, in vitro and in vivo.
Lévy, Laurence, Wei, Yu, Labalette, Charlotte, Wu, Yuanfei, Renard, Claire-Angélique, Buendia, Marie Annick, Neuveut, Christine   +6 more
openaire   +3 more sources

Beta-catenin in disease

Journal of Oral and Maxillofacial Pathology, 2016
In continuation with the previous review on "β-catenin in health", in this review we discuss the role of β-catenin in the pathogenesis of common oral lesions in the oral and maxillofacial region- oral potentially malignant disorders, their progression to oral squamous cell carcinoma, salivary gland tumors and odontogenic tumours.
Ashwini Balkuntla Krishnamurthy, BR Nagamalini, Uma Swaminathan, Sharada Prakash   +3 more
openaire   +4 more sources

E-cadherin can limit the transforming properties of activating β-catenin mutations [PDF]

, 2015
Wnt pathway deregulation is a common characteristic of many cancers. But only Colorectal Cancer predominantly harbours mutations in APC, whereas other cancer types (hepatocellular carcinoma, solid pseudopapillary tumours of pancreas) have activating ...
Alan R Clarke, Alastair Watson, Andrew D Campbell, Ann Hedley, Aoife Maguire, Brendan Doyle, David J Huels, Fatih Ceteci, Fei Song, Gabriela Kalna, Guenievre Moreaux, James Matthews, Karen R Reed, Lee Parry, Lionel Larue, Marc Leushacke, Nick Barker, Ola Söderberg, Owen J Sansom, Rachel A Ridgway, Runjan Chetty, Serra S, Simon Leedham, Sorina Radulescu, Sparks AB, Stefano Serra, Sujata Biswas, Valerie S Meniel   +27 more
core   +2 more sources

Phosphorylation of β-Catenin by AKT Promotes β-Catenin Transcriptional Activity [PDF]

Journal of Biological Chemistry, 2007
Increased transcriptional activity of beta-catenin resulting from Wnt/Wingless-dependent or -independent signaling has been detected in many types of human cancer, but the underlying mechanism of Wnt-independent regulation is poorly understood. We have demonstrated that AKT, which is activated downstream from epidermal growth factor receptor signaling,
Yanhua Zheng, Yan Xia, David H. Hawke, Dexing Fang, Gordon B. Mills, Ryuji Kobayashi, Zhimin Lu, Zhimin Lu, Jill Meisenhelder, Tony Hunter, Heinz Nika   +10 more
openaire   +3 more sources

Smad7:β-catenin Complex Regulates Myogenic Gene Transcription [PDF]

, 2019
Recent reports indicate that Smad7 promotes skeletal muscle differentiation and growth. We previously documented a non-canonical role of nuclear Smad7 during myogenesis, independent of its role in TGF-β signaling.
McDermott, John, Tetsuake, Miyake, Tripathi, Soma   +2 more
core   +1 more source