Results 31 to 40 of about 205,037 (299)

β-catenin promotes MTX resistance of leukemia cells by down-regulating FPGS expression via NF-κB

Cancer Cell International, 2020
Background Aberrant activation of β-catenin has been shown to play important roles in the chemoresistance of acute lymphoblastic leukemia (ALL), but the involvement and mechanism of β-catenin in methotrexate (MTX) resistance is poorly understood.
Shu-Guang Liu, Zhi-Xia Yue, Zhi-Gang Li, Rui-Dong Zhang, Hu-Yong Zheng, Xiao-Xi Zhao, Chao Gao   +6 more
doaj   +1 more source

90K Glycoprotein Promotes Degradation of Mutant β-Catenin Lacking the ISGylation or Phosphorylation Sites in the N-terminus

Neoplasia: An International Journal for Oncology Research, 2016
β-Catenin is a major transducer of the Wnt signaling pathway, which is aberrantly expressed in colorectal and other cancers. Previously, we showed that β-catenin is downregulated by the 90K glycoprotein via ISGylation-dependent degradation.
So-Yeon Park, Somy Yoon, Hangun Kim, Kyung Keun Kim   +3 more
doaj   +1 more source

Emerging Direct Targeting β-Catenin Agents

Molecules, 2022
Aberrant accumulation of β-catenin in the cell nucleus as a result of deregulation of the Wnt/β-catenin pathway is found in various types of cancer. Direct β-catenin targeting agents are being researched despite obstacles; however, specific β-catenin ...
Marianna Nalli, Domiziana Masci, Andrea Urbani, Giuseppe La Regina, Romano Silvestri   +4 more
doaj   +1 more source

Immunohistochemical analysis of E-cadherin,  -catenin,  -catenin,  -catenin, and neural cell adhesion molecule (NCAM) in chordoma [PDF]

Journal of Clinical Pathology, 2001
The epithelioid features seen in chordoma are unique among mesenchymal tumours. However, no detailed analysis regarding cell-cell communication has been conducted in this epithelioid tumour. The aims of this study were to investigate cell-cell communication in chordoma.By means of immunohistochemical techniques that incorporated a panel of monoclonal ...
Yukihide Iwamoto, Takahiko Naka, Masazumi Tsuneyoshi, Norio Shinohara, Yoshinao Oda, Hirokazu Chuman, Masashi Fukui   +6 more
openaire   +3 more sources

Concomitant loss of p120-catenin and β-catenin membrane expression and oral carcinoma progression with E-cadherin reduction.

PLoS ONE, 2013
The binding of p120-catenin and β-catenin to the cytoplasmic domain of E-cadherin establishes epithelial cell-cell adhesion. Reduction and loss of catenin expression degrades E-cadherin-mediated carcinoma cell-cell adhesion and causes carcinomas to ...
Kazunobu Sasaya, Haruka Sudo, Genta Maeda, Shuichi Kawashiri, Kazushi Imai   +4 more
doaj   +1 more source

Role of a Pdlim5:PalmD complex in directing dendrite morphology

Frontiers in Cellular Neuroscience
Neuronal connectivity is regulated during normal brain development with the arrangement of spines and synapses being dependent on the morphology of dendrites.
Yogesh Srivastava, Maxsam Donta, Maxsam Donta, Lydia L. Mireles, Adriana Paulucci-Holthauzen, M. Neal Waxham, M. Neal Waxham, Pierre D. McCrea, Pierre D. McCrea, Pierre D. McCrea   +9 more
doaj   +1 more source

Cleavage of Desmosomal Cadherins Promotes γ-Catenin Degradation and Benefits Wnt Signaling in Coxsackievirus B3-Induced Destruction of Cardiomyocytes

Frontiers in Microbiology, 2020
Coxsackievirus B3 (CVB3) is the primary etiologic agent of viral myocarditis, a major heart disease that occurs predominantly in children and young adolescents.
Guangze Zhao, Guangze Zhao, Huifang M. Zhang, Huifang M. Zhang, Ye Qiu, Ye Qiu, Xin Ye, Xin Ye, Decheng Yang, Decheng Yang   +9 more
doaj   +1 more source

iNOS activation regulates β-catenin association with its partners in endothelial cells. [PDF]

PLoS ONE, 2012
BACKGROUND: Signals that disrupt β-catenin association to cadherins may influence the translocation of β-catenin to the nucleus to regulate transcription.
Deyarina Gonzalez, Armando Rojas, Maria Beatriz Herrera, R Steven Conlan   +3 more
doaj   +1 more source

Amyloid precursor protein modulates β-catenin degradation

Journal of Neuroinflammation, 2007
Background The amyloid precursor protein (APP) is genetically associated with Alzheimer's disease (AD). Elucidating the function of APP should help understand AD pathogenesis and provide insights into therapeutic designs against this devastating ...
Chen Yuzhi, Bodles Angela M
doaj   +1 more source

miRNA‐29 regulates epidermal and mesenchymal functions in skin repair

FEBS Letters, EarlyView.
miRNA‐29 inhibits cell‐to‐cell and cell‐to‐matrix adhesion by silencing mRNA targets. Adhesion is controlled by complex interactions between many types of molecules coded by mRNAs. This is crucial for keeping together the layers of the skin and for regenerating the skin after wounding.
Lalitha Thiagarajan, Rosa Sanchez‐Alvarez, Chiho Kambara, Poojitha Rajasekar, Yuluang Wang, François Halloy, Jonathan Hall, Hans‐Jürgen Stark, Iris Martin, Petra Boukamp, Svitlana Kurinna   +10 more
wiley   +1 more source