Results 81 to 90 of about 220,813 (310)

Geometrically Tunable Scaffold‐Free Muscle Bioconstructs for Treating Volumetric Muscle Loss

Advanced Healthcare Materials, EarlyView.
Volumetric muscle loss is associated with traumatic muscle resulting in permanent functional impairment. Mold‐based, scaffold‐free, high‐density muscle tissue bioconstructs are developed in customizable geometric shapes and sizes. The transplanted rectangular solid‐shaped muscle bioconstructs improved muscle force recovery and tissue regeneration in ...
Bugra Ayan, Gaoxian Chen, Ishita Jain, Sha Chen, Gladys Chiang, Caroline Hu, Renato Reyes, Beu P. Oropeza, Ngan F. Huang   +8 more
wiley   +1 more source

Increasing β-catenin/Wnt3A activity levels drive mechanical strain-induced cell cycle progression through mitosis

eLife, 2016
Mechanical force and Wnt signaling activate β-catenin-mediated transcription to promote proliferation and tissue expansion. However, it is unknown whether mechanical force and Wnt signaling act independently or synergize to activate β-catenin signaling ...
Blair W Benham-Pyle, Joo Yong Sim, Kevin C Hart, Beth L Pruitt, William James Nelson   +4 more
doaj   +1 more source

Ascorbic Acid Modulates Collagen Properties in Glucocorticoid‐Induced Osteoporotic Bone: Insights into Chemical, Mechanical, and Biological Regulation

Advanced Healthcare Materials, EarlyView.
Osteoporosis from long‐term glucocorticoid (GIOP) use elevates susceptibility to fracture. This study shows GCs impair ascorbic acid (AA) metabolism in osteoblasts, collagen synthesis and extracellular matrix integrity. AA enhanced collagen biochemical and mechanical properties and restored osteoblast and endothelial function. These findings underscore
Micaila DE Curtis, Yoontae Kim, Rahul Patil, Xinran Zhang, Meth Jayatilake, Orelle Bulgin, Peter Lialios, Sana Surrency, Soraya Tarrah, Argyris K. Lazaris, Alison Grafton, James Williams IV, Seyedeh Boshra Nouraie, Maria Bizaki, Penelope Xeron, Edward Van Keuren, Jonathan E. Seppala, Evagelia C. Laiakis, Joanna B. Kitlinska, Stella Alimperti   +19 more
wiley   +1 more source

Alpha-T-catenin is expressed in peripheral nerves as a constituent of Schwann cell adherens junctions

Biology Open, 2022
Anthea Weng, Erik E. Rabin, Annette S. Flozak, Sergio E. Chiarella, Raul Piseaux Aillon, Cara J. Gottardi   +5 more
doaj   +1 more source

Activated Wnt/ß-catenin signaling in melanoma is associated with decreased proliferation in patient tumors and a murine melanoma model [PDF]

, 2009
Andy J. Chien, Erin Moore, Anke S. Lonsdorf, Rima M. Kulikauskas, Bonnie Gould Rothberg, Aaron J. Berger, Michael B. Major, Sam T. Hwang, David L. Rimm, Randall T. Moon   +9 more
openalex   +1 more source

ICG-001, an Inhibitor of the β-Catenin and cAMP Response Element-Binding Protein Dependent Gene Transcription, Decreases Proliferation but Enhances Migration of Osteosarcoma Cells [PDF]

, 2021
Geoffroy Danieau, Sarah Morice, Sarah Renault, Régis Brion, Kévin Biteau, Jérôme Amiaud, Marie Cadé, Dominique Heymann, Frédéric Lézot, Franck Verrecchia, Françoise Rédiní, Bénédicte Brounais-Le Royer   +11 more
openalex   +1 more source

Platelet Lysate–Enriched Human Induced Pluripotent Stem Cell–Derived Chondrocyte Sheets for Bone Defect Repair via Endochondral Ossification

Advanced Healthcare Materials, EarlyView.
Human iPSC‐derived hypertrophic chondrocyte sheet promotes bone regeneration. Abstract Bone defects are a major clinical challenge, primarily owing to the limited self‐healing capacity of bones and the high risk of complications associated with conventional treatment strategies.
Yiwei Chen, Jiali Lin, Jiapeng Li, Yiwei Hu, Jiansen Su, Yu Miao, Lanlan Wang, Qian Tang, Changqing Zhang, Junhui Yin   +9 more
wiley   +1 more source

A transphyletic study of metazoan β-catenin protein complexes

Zoological Letters
Beta-catenin is essential for diverse biological processes, such as body axis determination and cell differentiation, during metazoan embryonic development.
Ivan Mbogo, Chihiro Kawano, Ryotaro Nakamura, Yuko Tsuchiya, Alejandro Villar-Briones, Yoshitoshi Hirao, Yuuri Yasuoka, Eisuke Hayakawa, Kentaro Tomii, Hiroshi Watanabe   +9 more
doaj   +1 more source

Amine‐Functionalized Chitosan/dECM Composite Promotes Cutaneous Regeneration and Hair Follicle Activation by Regulating Oxidative Stress and Inflammation

Advanced Healthcare Materials, EarlyView.
An amine‐functionalized chitosan and hydrolyzed dECM composite promotes cutaneous regeneration by modulating oxidative stress and inflammatory pathways. The material accelerates wound closure and stimulates hair follicle activation in UV‐damaged cutaneous tissue.
Yu‐Jin Kim, Seokheon Hong, Jae Hwi Lee, Jongmin Lee, Jae Jun Kang, Jiseon Bae, Jino Kim, Dong‐Hwee Kim, Jin Yoo, Mi Sun Cha, Su Hee Kim, Youngmee Jung   +11 more
wiley   +1 more source

5‐Hydroxytryptamine promotes hepatocellular carcinoma proliferation by influencing β‐catenin [PDF]

, 2015
Sarwat Fatima, Xiaoke Shi, Zesi Lin, Guoqing Chen, Xiaohua Pan, Justin Che‐Yuen Wu, John Ho, Nikki P. Lee, Hengjun Gao, Ge Zhang, Aiping Lü, Zhao Xiang Bian   +11 more
openalex   +1 more source