Results 111 to 120 of about 1,103 (171)

ChemInform Abstract: Synthesis and Oxidative Fragmentation of Catharanthine Analogues. Comparison to the Fragmentation—Coupling of Catharanthine and Vindoline.

ChemInform, 1998
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
R. J. SUNDBERG, J. HONG, S. Q. SMITH, M. SABAT, I. TABAKOVIC   +4 more
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Photoactive C16-C21 fragmentation of catharanthine

Tetrahedron Letters, 1991
Photolysis of catharanthine in the presence of several potential electron acceptors and cyanide ion leads to either addition of cyanide at C3 and C5 or to C16-C21 fragmentation and addition of cyanide at C21.
Richard J. Sundberg, Patrice Desos, Kumar G. Gadamasetti, Michal Sabat   +3 more
openaire   +1 more source

Catharanthine: A novel stimulator of pancreatic enzyme release

Cell and Tissue Research, 1978
The plant alkaloid, catharanthine, was shown to stimulate release of amylase from pancreatic fragments and to cause extensive degranulation of pancreatic acinar cells with accumulation of membrane material in the Golgi region. The extent and time course of maximal catharanthine stimulation was comparable to that induced by the cholinergic analog ...
openaire   +2 more sources

Asymmetric Formal Synthesis of (+)-Catharanthine via Desymmetrization of Isoquinuclidine

Organic Letters, 2019
Although (+)-catharanthine is an attractive alkaloid for both clinical research and organic synthetic chemistry, only a limited number of approaches for its catalytic asymmetric synthesis exist. Herein, we describe a novel strategy for synthesizing a chiral intermediate of (+)-catharanthine via phosphoric acid-catalyzed asymmetric desymmetrization of a
Masato Kono, Shingo Harada, Tomoyuki Nozaki, Yoshinori Hashimoto, Shun-ichi Murata, Harald Gröger, Yusuke Kuroda, Ken-ichi Yamada, Kiyosei Takasu, Yasumasa Hamada, Tetsuhiro Nemoto   +10 more
openaire   +3 more sources

Mechanism of interaction of vinca alkaloids with tubulin: catharanthine and vindoline

Biochemistry, 1991
The interactions of the vinca alkaloid drugs catharanthine and vindoline with tubulin have been investigated and compared with those of vinblastine and vincristine. Both drugs were found to be less effective in bringing about the inhibition of tubulin self-assembly into microtubules than vincristine and vinblastine, the drug to protein molar ratio ...
V, Prakash, S N, Timasheff
openaire   +2 more sources

SOME ASPECTS OF THE CHEMISTRY OF CATHARANTHINE AND CLEAVAMINE

Canadian Journal of Chemistry, 1965
Chemical and spectroscopic evidence is presented for an interesting acid-catalyzed rearrangement of the alkaloid catharanthine. Four reaction products (descarbomethoxycatharanthine and cleavamine and its two dihydro derivatives) were isolated, and their formation is rationalized by a mechanism involving ring-opened intermediates. Evidence is presented
James P. Kutney, Richard T. Brown, Edward Piers   +2 more
openaire   +1 more source

Catharanthine tartrate ameliorates osteoclastogenesis by destabilizing HIF-1α

Cellular Signalling
With the aging population, postmenopausal osteoporosis (PMOP), clinically manifested by reduced bone density, weakened skeletal strength, and compromised skeletal microstructure, has become the most prevalent type. The decline in estrogen levels fosters oxidative stress and osteoclastogenesis, which significantly enhance the activity of osteoclasts ...
Luqiong, Cai, Chenxin, Yu, Binli, Zhao, Qihang, Wu, Haibo, Liang, Meng, Zhou, Jiansen, Miao, Jiangtao, Luo, Jiake, Xu, Haiming, Jin, Youjin, Pan   +10 more
openaire   +2 more sources

Réarrangement du squelette de la catharanthine. IV. Nor-5 catharanthine et couplage avec la vindoline.

Canadian Journal of Chemistry, 1979
5-Norcatharanthine 3 was prepared from catharanthine 5. The coupling of the corresponding Nb-oxide 10 with vindoline 4, under modified Polonovski reaction conditions, led to two dimers without breaking the structural framework.The isolation of 5-nor-16-demethoxycarbonylcatharanthine 20 by cleavage of one of the coupling products (18) of vindoline 4 ...
Ratremaniaina Zo Andriamialisoa, Nicole Langlois, Yves Langlois, Pierre Potier, Peter Bladon   +4 more
openaire   +1 more source

Synthesis of fluorinated catharanthine analogues and investigation of their biomimetic coupling with vindoline

Organic & Biomolecular Chemistry, 2013
The syntheses of 20,20-difluorocatharanthine and congeners, starting from the naturally occurring catharanthine, are reported. The fluorinated catharanthine analogues were investigated as potential precursors to dimeric Vinca alkaloids of the vinflunine family. However, the biomimetic coupling of the fluorinated catharanthine derivatives with vindoline
Giovanelli, Emerson, Moisan, Lionel, Comesse, Sébastien, Leroux, Sébastien, Rousseau, Bernard, Hellier, Paul, Nicolas, Marc, Doris, Eric   +7 more
openaire   +3 more sources

Rearrangement du squelette de la catharanthine

Tetrahedron, 1976
Resume Catharanthine N -oxide 1 leads through a [2,3]-sigmatropic rearrangement to 2 whose structure is established by chemical studies and confirmed by X-ray analysis.
Y. Langlois, F. Guéritte, R.Z. Andriamialisoa, N. Langlois, P. Potier, A. Chiaroni, C. Riche   +6 more
openaire   +1 more source