Results 121 to 130 of about 1,103 (171)

On the rearrangement of catharanthine, stemmadenine and tabersonine in acetic acid

Tetrahedron, 1971
Abstract Experimental details of the reaction of tabersonine (VII) and stemmadenine (XII) in refluxing acetic acid are presented: the main product in the latter reaction is O-acetylstemmadenine (XIII). The formation of partially racemic pseudocatharanthine (III) both in the treatment of catharanthine (I) with hot acetic acid and in Kutney's ...
R.T. Brown, J.S. Hill, G.F. Smith, K.S.J. Stapleford   +3 more
openaire   +1 more source

Catharanthine oxidation in flavin mononucleotide-mediated catharanthine-vindoline coupling reaction for synthesis of dimeric indole alkaloids under near-ultraviolet light

Journal of Bioscience and Bioengineering, 1999
A reaction model for the flavin mononucleotide-mediated coupling of catharanthine (C) and vindoline (V) under near-ultraviolet light was established based on the results of experiments on the effects of various physical and chemical factors on the disappearance of C and V, and the synthesis of the product, a dihydropyridinium intermediate (IM).
K, Hirata, T, Akagi, S, Duangteraprecha, M, Honda, Y, Sakamoto, H, Nagase, K, Miyamoto   +6 more
openaire   +2 more sources

The acyclic dienamine–indoloacrylate addition route to catharanthine

Tetrahedron, 2008
Abstract Condensation of methyl 3-benzyl-1,2,3,4,5,6-hexahydroazepino[4,5-b]indole-5-carboxylate (3) with methyl Z-4-formylhex-3-enoate (6) gave cis-fused dimethyl 5-benzyl-4-ethyl-2,4a,5,6,7,12-hexahydro-1H-benzo[2,3]azepino[4,5-b]indole-2,12b-dicarboxylate and its trans-fused diastereomer.
Nan Huang, Tao Jiang, Tiansheng Wang, Mustapha Soukri, Rakesh Ganorkar, Bruce Deker, Jean-Michel Léger, Jose Madalengoitia, Martin E. Kuehne   +8 more
openaire   +1 more source

Rearrangement of catharanthine, stemmadenine, and tabersonine in acetic acid

Journal of the Chemical Society D: Chemical Communications, 1969
Treatment of tabersonine with refluxing acetic acid under nitrogen yielded a new base, allocatharanthine (VI), and the derived (VII), but failed to produce detectable quantities of (±)-catharanthine or pseudocatharanthine, nor did similar treatment of stemmadenine afford any of these compounds.
R. T. Brown, J. S. Hill, G. F. Smith, K. S. J. Stapleford, J. Poisson, M. Muquet, N. Kunesch   +6 more
openaire   +1 more source

ChemInform Abstract: REARRANGEMENT OF CATHARANTHINE. (V). 21‐CYANOCATHARANTHINE

Chemischer Informationsdienst, 1983
AbstractAus Catharanthin (I) werden die Cyanverbindungen (II) und (III) sowie zahlreiche weitere Derivate synthetisiert.
P. MANGENEY, N. LANGLOIS, C. LEROY, C. RICHE, Y. LANGLOIS   +4 more
openaire   +1 more source

Enhancement of producing catharanthine by suspension growth ofCatharanthus roseus

Biotechnology Letters, 1990
Increased production of catharanthine (about 200 μg/mL) was obtained at low light intensity under chemostat cultivation as compared with batch and fed-batch processes. Photo-inhibition was observed at high light intensity. Cells after being frozen with 5% DMSO produced more catharanthine (up to 350 μg/L) in batch culture than those from conventional ...
Hyung H. Park, Suk K. Choi, Jae K. Kang, Hyeon Y. Lee   +3 more
openaire   +1 more source

Catharanthine alkaloids are noncompetitive antagonists of muscle-type nicotinic acetylcholine receptors

Neurochemistry International, 2010
We compared the interaction of several catharanthine alkaloids including, ibogaine, vincristine, and vinblastine, with that for the noncompetitive antagonist phencyclidine (PCP) at muscle nicotinic acetylcholine receptors (AChRs) in different conformational states.
Hugo R, Arias, Dominik, Feuerbach, Katarzyna M, Targowska-Duda, Krzysztof, Jozwiak   +3 more
openaire   +2 more sources

Vindoline and catharanthine production in multiple shoot cultures of Catharanthus roseus

Journal of Fermentation and Bioengineering, 1990
Abstract The effects of phytohormones and light on alkaloid production were investigated using multiple shoot cultures of Catharanthus roseus . A high and balanced level of vindoline and catharanthine, 765 and 552 μg, respectively, useful materials for chemical or enzymatic synthesis of antineoplastic bisindole alkaloids, was obtained per gram of ...
Kazumasa Hirata, Masato Horiuchi, Teru Ando, Kazuhisa Miyamoto, Yoshiharu Miura   +4 more
openaire   +1 more source

ChemInform Abstract: SYNTHESIS OF (.+‐.)‐CATHARANTHINE VIA ORGANOPALLADIUM CHEMISTRY

Chemischer Informationsdienst, 1979
AbstractDie Synthese des Alkaloids Catharanthin (III) aus (I) über die Zwischenstufe (II) wird in an sich bekannter Weise beschrieben.
B. M. TROST, S. A. GODLESKI, J. L. BELLETIRE   +2 more
openaire   +1 more source

The Coupling of Catharanthine and Vindoline to Form 3′,4′-Anhydrovinblastine by Haemoproteins and Haemin

Planta Medica, 1988
The enzymic coupling of catharanthine and vindoline can be performed with plant peroxidases in a reaction which yields 3',4'-anhydrovinblastine (AVLB) as the major product. This has led to an investigation of other sources of peroxidase activity and haem. High levels of AVLB were obtained using microperoxidase (haem-undecapeptide) and haemin, and lower
A, Goodbody, T, Endo, J, Vukovic, M, Misawa   +3 more
openaire   +2 more sources