Results 141 to 150 of about 1,359 (207)

Vincristine Beyond Mitosis: Uncovering a First Link to G-Quadruplex DNA in Cancer Cells. [PDF]

Int J Mol Sci
Di Porzio A, Persico C, Romano F, Barra A, Aiello I, D'Auria L, Abate S, D'Aria F, Giancola C, Cinquegrana E, Di Leva FS, Amato J, Marzano S, Iaccarino N, Randazzo A.   +14 more
europepmc   +1 more source

UV-B and far-red light shape morphological and phytochemical responses in kratom. [PDF]

Front Plant Sci
Zhang M, Kanumuri SRR, Fisher PR, Pearson BJ, Sharma A, McCurdy CR, Chen J.   +6 more
europepmc   +1 more source

Biomanufacture of diverse chemicals in yeast. [PDF]

Innovation (Camb)
Chen R, Jiang H, Zhou YJ, Li C, Liu L, Zhang L.   +5 more
europepmc   +1 more source

Asymmetric Formal Synthesis of (+)-Catharanthine via Desymmetrization of Isoquinuclidine

Organic Letters, 2019
Although (+)-catharanthine is an attractive alkaloid for both clinical research and organic synthetic chemistry, only a limited number of approaches for its catalytic asymmetric synthesis exist. Herein, we describe a novel strategy for synthesizing a chiral intermediate of (+)-catharanthine via phosphoric acid-catalyzed asymmetric desymmetrization of a
Masato Kono, Shingo Harada, Tomoyuki Nozaki, Yoshinori Hashimoto, Shun-ichi Murata, Harald Gröger, Yusuke Kuroda, Ken-ichi Yamada, Kiyosei Takasu, Yasumasa Hamada, Tetsuhiro Nemoto   +10 more
openaire   +4 more sources

Mechanism of interaction of vinca alkaloids with tubulin: catharanthine and vindoline

Biochemistry, 1991
The interactions of the vinca alkaloid drugs catharanthine and vindoline with tubulin have been investigated and compared with those of vinblastine and vincristine. Both drugs were found to be less effective in bringing about the inhibition of tubulin self-assembly into microtubules than vincristine and vinblastine, the drug to protein molar ratio ...
V, Prakash, S N, Timasheff
openaire   +3 more sources

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A Rapid Procedure for the Isolation of Catharanthine, Vindoline and Vinblastine

Planta Medica, 1983
Null Atta-Ur-Rahman
exaly   +3 more sources

CATHARANTHINE

, 1976
Darshan Ranganathan, Subramania Ranganathan   +1 more
openaire   +2 more sources

Synthesis and oxidative fragmentation of catharanthine analogs. Comparison to the fragmentation — Coupling of catharanthine and vindoline

Tetrahedron, 1998
Abstract Two new analogs of catharanthine have been synthesized in racemic form. They differ from catharanthine in the fusion of the indole ring to the non-aromatic portion of the iboga skeleton, with the [2,3] fusion present in catharanthine being replaced by [2,1] and [3,2] fusions.
Richard J Sundberg, Jian Hong, Stanton Q Smith, Michal Sabat, Ibro Tabakovic   +4 more
openaire   +1 more source

ChemInform Abstract: Synthesis and Oxidative Fragmentation of Catharanthine Analogues. Comparison to the Fragmentation—Coupling of Catharanthine and Vindoline.

ChemInform, 1998
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
R. J. SUNDBERG, J. HONG, S. Q. SMITH, M. SABAT, I. TABAKOVIC   +4 more
openaire   +1 more source

Oxidative fragmentation of catharanthine by dichlorodicyanoquinone

The Journal of Organic Chemistry, 1991
Oxidation of catharanthine by DDQ leads to formation of products resulting from fragmentation of the C16-C21 bond as well as C3 and C5 dehydrogenation. Among the products are compounds containing a cyclopropane ring formed by bonding between C14 and C16.
Richard J. Sundberg, Phyllis J. Hunt, Patrice Desos, Kumar G. Gadamasetti   +3 more
openaire   +1 more source