Results 81 to 90 of about 1,359 (207)

Direct Coupling of Catharanthine and Vindoline to Provide Vinblastine:  Total Synthesis of (+)- and ent-(−)-Vinblastine

, 2016
A direct coupling of catharanthine with vindoline to provide vinblastine is detailed along with key mechanistic and labeling studies. Following an Fe(III)-promoted coupling reaction initiated by generation of a presumed catharanthine amine radical cation
Dale L. Boger (1306542), David A. Colby (1944655), Hayato Ishikawa (2134999)   +2 more
core   +1 more source

Jasmonic Acid Effect on the Fatty Acid and Terpenoid Indole Alkaloid Accumulation in Cell Suspension Cultures of Catharanthus roseus

Molecules, 2014
The stress response after jasmonic acid (JA) treatment was studied in cell suspension cultures of Catharanthus roseus. The effect of JA on the primary and secondary metabolism was based on changes in profiles of fatty acids (FA) and terpenoid indole ...
Guitele Dalia Goldhaber-Pasillas, Natali Rianika Mustafa, Robert Verpoorte   +2 more
doaj   +1 more source

Bio-production of vindoline and catharanthine by recombinant yeast cell factories

, 2021
International audienceThe tropical plant Madagascar periwinkle (Catharanthus roseus) is a natural source of anticancer monoterpene indole alkaloids (MIA), such as vinblastine and vincristine, two molecules of major interest and therapeutic values.
Marc, Jillian, Kulagina, Natalja, Carqueijeiro, Ines, Heredia, Vladimir, Lanoue, Arnaud, St-Pierre, Benoit, Papon, Nicolas, Unlubayir, Marianne, Guirimand, Grégory, Imbault, Nadine, Courdavault, Vincent, Lemos Cruz, Pamela, Oudin, Audrey, Rose, Sébastien, Melin, Céline, Koudounas, Konstantinos, Besseau, Sébastien, de Craene, Johan-Owen, Giglioli-Guivarc’h, Nathalie, Clastre, Marc   +19 more
core   +1 more source

CrERF5, an AP2/ERF Transcription Factor, Positively Regulates the Biosynthesis of Bisindole Alkaloids and Their Precursors in Catharanthus roseus

Frontiers in Plant Science, 2019
Catharanthus roseus contains a variety of monoterpenoid indole alkaloids (MIAs), among which bisindole alkaloids vinblastine and vincristine are well-known to have antitumor effects and widely used in clinical treatment.
Qifang Pan, Chenyi Wang, Zhiwei Xiong, Hang Wang, Xueqing Fu, Qian Shen, Bowen Peng, Yanan Ma, Xiaofen Sun, Kexuan Tang   +9 more
doaj   +1 more source

Optimization of 3', 4'-Anhydrovinblastine Synthesis Using Crude Extracts of Irradiated with Near-Ultraviolet Light

Natural Product Communications, 2016
Dimeric indole alkaloids (DIAs), such as vinblastine and vincristine, found in Catharanthus roseus are used clinically as antitumor drugs. A stable supply of DIAs is desired because these alkaloids are very expensive due to their low abundance in plants.
Mamiko Asano, Kazuo Harada, Akiko Umeno, Kazumasa Hirata   +3 more
doaj   +1 more source

Enhanced catharanthine and vindoline production in suspension cultures of by ultraviolet-B light-1

, 2011
Ed cell suspension culture formed after 6 days of inoculation in the above-mentioned medium. , Microscopic observation of six-day-old culture: arrows indicate divided cells. , Fluorescence microscopy (495 nm excitation and 520 nm emission) of FDA-stained
Chelliah Jayabaskaran (92029), Shilpa Ramani (74710)   +1 more
core   +1 more source

Enhanced catharanthine and vindoline production in suspension cultures of by ultraviolet-B light-5

, 2011
Rowth regulators and cultured under 16 h day/8 h dark photoperiod or under complete dark conditions. Cells were harvested on the indicated day and the fresh weight was determined. Values are expressed as the means ± SD (n = 3).Copyright information:Taken
Chelliah Jayabaskaran (92029), Shilpa Ramani (74710)   +1 more
core   +1 more source

Production of Vinblastine by Chemical Coupling of Vindoline Extracted from Cultivated Plants and Catharanthine from Hairy Root Cultures in Vinca(Catharanthine roseus)

, 1993
Vinblastine, an anticancer agent was produced by chemical coupling of two different monomeric indole alkaloids, vinblastine and catharanthine in the presence of ferric ion. Vindoline was efficiently extracted from the leaves of vinca (Cafharanthus roseus)
정경희, 유장렬, 곽상수, 이흔, 박상우   +4 more
core  

Enhanced catharanthine and vindoline production in suspension cultures of by ultraviolet-B light-0

, 2011
Rowth regulators and cultured under 16 h day/8 h dark photoperiod or under complete dark conditions. Cells were harvested on the indicated day and the fresh weight was determined. Values are expressed as the means ± SD (n = 3).Copyright information:Taken
Chelliah Jayabaskaran (92029), Shilpa Ramani (74710)   +1 more
core   +1 more source

Bioengineered Indoor Farming Approaches: LED Light Spectra and Biostimulants for Enhancing Vindoline and Catharanthine Production in Catharanthus roseus

Horticulturae
Light quality and biostimulants regulate alkaloid biosynthesis and promote plant growth, but their combined effects on vindoline (VDL) and catharanthine (CAT) production in Catharanthus roseus remain underexplored.
Alessandro Quadri, Bianca Sambuco, Mattia Trenta, Patrizia Tassinari, Daniele Torreggiani, Laura Mercolini, Michele Protti, Alessandra Zambonelli, Federico Puliga, Alberto Barbaresi   +9 more
doaj   +1 more source