Results 181 to 190 of about 16,226 (208)

Effects of the cathelicidin LL-37 on intestinal epithelial barrier integrity

Regulatory Peptides, 2009
The human cathelicidin LL-37 is involved in innate immune responses, angiogenesis and wound healing. Functions in maintenance and re-establishment of intestinal barrier integrity have not been characterized yet. Following direct and indirect stimulation of human colonic HT-29 and Caco-2 cells with LL-37 the cellular viability, rate of apoptosis ...
Jan-Michel, Otte, Anna-Elisabeth, Zdebik, Stephan, Brand, Ansgar M, Chromik, Sarah, Strauss, Frank, Schmitz, Lars, Steinstraesser, Wolfgang E, Schmidt   +7 more
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Cathelicidin LL-37 bloodstream surveillance is down regulated during septic shock

Microbes and Infection, 2013
Host defense peptides are ancient weapons of the innate immunity. The human cathelicidin LL-37 protects the epithelial barrier against infection and is constitutively secreted in the bloodstream by immune cells. Current knowledge claims that LL-37 is up regulated upon infection.
Denise Frediani, Barbeiro, Hermes Vieira, Barbeiro, Fernando Godinho, Zampieri, Marcel Cerqueira, César Machado, Francisco, Torggler Filho, Débora Maria, Gomes Cunha, Alessandra Carvalho, Goulart, Irineu Tadeu, Velasco, Luiz, Monteiro da Cruz Neto, Heraldo, Possolo de Souza, Fabiano, Pinheiro da Silva   +10 more
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In silico assessment of missense point mutations on human cathelicidin LL-37

Journal of Molecular Graphics and Modelling, 2023
Cathelicidin antimicrobial peptides are a diverse family of cationic amphipathic peptides with multiple activities. In humans, cathelicidin LL-37 is one of the main host defense peptides with a remarkable medical and biotechnological potential. Deregulation of LL-37 expression has been associated with inflammatory diseases. However the effects of point
William F. Porto, Sergio A. Alencar
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Cathelicidin LL-37 (an antimicrobial peptide)-induced colistin dependence in Acinetobacter baumannii

Diagnostic Microbiology and Infectious Disease, 2020
In this study, we demonstrated the development of colistin dependence in Acinetobacter baumannii isolates after exposure to the human cationic antimicrobial peptide LL-37. The LL-37-induced colistin-dependent mutants showed susceptibility to many other antibiotics and IS1595 or ATTT insertions in LpxACD.
Ji-Young, Lee, Yoon-Kyoung, Hong, Kwan Soo, Ko   +2 more
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Recombinant expression of human cathelicidin (hCAP18/LL-37) in Pichia pastoris

Biotechnology Letters, 2006
The constitutive expression of human cathelicidin LL-37 antimicrobial peptide was achieved using the methylotrophic yeast, Pichia pastoris. An LL-37 cDNA clone was amplified by PCR using human fetal cDNA library as template. The 111 bp fragment encoding mature LL-37 gene was subcloned into pGAPZ-E, an episomal form of the pGAPZB vector incorporating ...
In-Pyo, Hong, Sung-Jae, Lee, Yong-Seok, Kim, Shin-Geon, Choi   +3 more
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Histone-deacetylase inhibitors induce the cathelicidin LL-37 in gastrointestinal cells

Molecular Immunology, 2004
Histone-deacetylase (HDAC) -inhibitors enhance acetylation of core proteins and this is linked to formation of transcriptionally active chromatin in various cells. In this study, the effect of HDAC inhibitors (butyrate, trichostatin A (TSA)) on the expression of the cathelicidin LL-37 in colon, gastric and hepatocellular cells was investigated.LL-37 ...
Jürgen, Schauber, Konrad, Iffland, Susanne, Frisch, Theodor, Kudlich, Bernd, Schmausser, Matthias, Eck, Thomas, Menzel, Andrea, Gostner, Hardi, Lührs, Wolfgang, Scheppach   +9 more
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Tissue-specific Regulation of Innate Immune Responses by Human Cathelicidin LL-37

Current Pharmaceutical Design, 2018
Cathelicidins form one of the major families of antimicrobial peptides and have been identified in many vertebrates, including humans. LL-37, the only human member of the cathelicidin family, is detected in most sites of the human body that is normally exposed to microbes, including the epithelial lining of the skin, gastrointestinal tract ...
Panjit, Chieosilapatham, Shigaku, Ikeda, Hideoki, Ogawa, Francois, Niyonsaba   +3 more
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Heterogeneous expression of human cathelicidin hCAP18/LL-37 in inflammatory bowel diseases

European Journal of Gastroenterology & Hepatology, 2006
Inflammatory bowel diseases (IBDs) are characterized by a breakdown of colon epithelial barrier function. Antimicrobial peptides like cathelicidins are molecules of the innate immune system located at epithelial surfaces. Cathelicidins influence microbial growth and inflammation and may play a role in IBD.
Jürgen, Schauber, Daniel, Rieger, Frank, Weiler, Jan, Wehkamp, Matthias, Eck, Klaus, Fellermann, Wolfgang, Scheppach, Richard L, Gallo, Eduard F, Stange   +8 more
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Serum levels of peptide cathelicidin LL-37 in elderly patients with depression

Psychiatry Research, 2017
Cathelicidin LL-37 is a small cationic that plays an important role in antimicrobial defense, as it kills a broad spectrum of infectious agents by disrupting their membranes, including gram-positive and gram-negative bacteria, some viruses and fungi; and it neutralizes activity of bacterial endotoxins.
Elżbieta, Kozłowska, Adam, Wysokiński, Ewa, Brzezińska-Błaszczyk   +2 more
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Study of cathelicidin (LL-37) immunoexpression in the skin of vitiligo patients

Archives of Dermatological Research
Vitiligo is a pigmentary disorder acquired and caused by the loss or destruction of melanocytes from the epidermis. There is strong proof that vitiligo is mainly an autoimmune disease. Cathelicidin (LL37), an antimicrobial polypeptide, is an important part of the innate immune system and has a role in different skin autoimmune diseases.
Lamia Hamouda, Elgarhy, Basma Ramadan Refaey, Ramadan, Fersan Abd Allah, Sallam, Dalya Ayman, Iskandarani, El-Sayed Shaaban, Hewedy   +4 more
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