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Multi-omics resources for the Australian southern stuttering frog (Mixophyes australis) reveal assorted antimicrobial peptides. [PDF]
Tang S +4 more
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Cathelicidins, essential gene-encoded mammalian antibiotics
Journal of Molecular Medicine, 2002Cathelicidins are a class of gene-encoded antibiotics found exclusively in mammals. In vitro and in vivo studies indicate they are effector molecules of mammalian innate immunity that can provide a first line of defense against an array of micro-organisms.
Mohamed Zaiou, Richard L Gallo
exaly +3 more sources
Amphibian cathelicidin fills the evolutionary gap of cathelicidin in vertebrate
Amino Acids, 2011Cathelicidins comprise a family of antimicrobial peptides (AMPs) sharing a highly conserved cathelin domain, and play a central role in the innate defense against infection in most of vertebrates. But so far it has not yet been found in amphibians although a large number of other groups of AMPs have been identified.
Xue, Hao +7 more
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Structure and Biology of Cathelicidins
2002Cathelicidins are a recently discovered family of effector molecules in innate immunity. In the past few years, a great deal of investigations have elucidated several aspects of their biology, such as the gene structure and activation mechanism. Despite substantial progress in the field, several issues remain to be clarified, including the biological ...
ZANETTI M. +3 more
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The Cathelicidins - Structure, Function and Evolution
Current Protein & Peptide Science, 2005The cathelicidin family of host defense peptides includes a group of cationic and usually amphipathic peptides that display a variety of activities related to host defense functions, among which the most acknowledged is a direct antimicrobial activity against various microbial pathogens.
TOMASINSIG L., ZANETTI, Margherita
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Defensins and cathelicidins in gastrointestinal infections
Current Opinion in Gastroenterology, 2007To review recently published studies presenting novel and relevant information on antimicrobial peptides in gastrointestinal infections.Defensins and cathelicidins are important antimicrobial peptides expressed by the gastrointestinal epithelium. Their localization and regulation have been the focus of current research establishing the relevance of ...
Jan, Wehkamp +2 more
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Cathelicidins - Natures Attempt at Combinatorial Chemistry
Combinatorial Chemistry & High Throughput Screening, 2005Cathelicidins are a family of diverse antimicrobial peptides found in granules of mammalian neutrophils. Cathelicidins are active against a broad range of microbes in different environments. Aside from their antimicrobial activity, cathelicidins possess other biological properties including cytotoxic activity towards mammalian cells.
Ole E, Sorensen, Niels, Borregaard
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International Journal of Systems Biology and Biomedical Technologies, 2013
Cathelicidins constitute important antimicrobial peptides of innate immunity. In order to elucidate the evolutionary history of cathelicidins, the author performed comprehensive phylogenetic analyses of cathelicidin homologs in all available genomes including those completed recently. The organization of cathelicidin genes, as well as the secondary and
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Cathelicidins constitute important antimicrobial peptides of innate immunity. In order to elucidate the evolutionary history of cathelicidins, the author performed comprehensive phylogenetic analyses of cathelicidin homologs in all available genomes including those completed recently. The organization of cathelicidin genes, as well as the secondary and
openaire +2 more sources

