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Structural and functional diversity of cathelicidins.
2017Cathelicidins are a ubiquitous family of host defence peptides (HDPs) in vertebrate animals. Unlike other HDP families, they are defined by the common and relatively well conserved proregion rather than the mature active peptides, which are highly diverse and conform to at least five different structural groups.
TOSSI, ALESSANDRO +3 more
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Sensitivity of Chlamydia suis to cathelicidin peptides
Veterinary Microbiology, 2007Nine Chlamydia suis isolates, obtained from pigs with conjunctivitis, were molecularly characterized by ompA sequencing and their in vitro susceptibility to six cathelicidin peptides (SMAP-29, BAC-7, BMAP-27, BMAP-27, BMAP-28, PG-1, LL-37) determined in cell culture.
DONATI, MANUELA +11 more
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Cathelicidins, multifunctional peptides of the innate immunity
Journal of Leukocyte Biology, 2003AbstractCathelicidins comprise a family of mammalian proteins containing a C-terminal cationic antimicrobial domain that becomes active after being freed from the N-terminal cathelin portion of the holoprotein. Many other members of this family have been identified since the first cathelicidin sequences were reported 10 years ago.
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The Janus Face of Cathelicidin in Tumorigenesis
Current Medicinal Chemistry, 2014Cathelicidin is a host defense peptide with multiple innate immunity-related functions. Recent findings indicate that cathelicidin is frequently dysregulated in human cancers where it plays a paradoxical yet dominant role in the regulation of tumor malignancy.
W K K, Wu +10 more
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Antimicrobial Peptides: Defensins and Cathelicidins
20101 Defensins 2 Cathelicidins 3 Concluding Remarks Keywords: antimicrobial peptides, defensins and cathelicidins; antimicrobial defense-neutrophils and polymorphonucleated neutrophilic granulocytes (PMN); defensins, large and growing family of antimicrobial peptides; variability of expression; antimicrobial mechanisms; defensin ...
Robert I. Lehrer, Tomas Ganz
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Cathelicidins positively regulate pancreatic β‐cell functions
The FASEB Journal, 2015Cathelicidins are pleiotropic antimicrobial peptides largely described for innate antimicrobial defenses and, more recently, immunomodulation. They are shown to modulate a variety of immune or nonimmune host cell responses. However, how cathelicidins are expressed by β cells and modulate β‐cell functions under steady‐state or ...
Jia, Sun +9 more
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Rosazea: Welche Rolle spielt Cathelicidin?
hautnah dermatologie, 2018In einer aktuellen Studie wurde untersucht, inwiefern Vitamin D und Cathelicidin, ein Molekul der angeborenen Immunitat, zur Rosazea beitragen.
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Cathelicidin Antimicrobial Peptides Modulate Angiogenesis
2007Antimicrobial peptides (AMPs) are effector molecules of the innate immune system. In addition their direct antimicrobial activity AMPs modulate angiogenesis. This chapter reviews the current knowledge about the link between AMPs and angiogenesis.
Rembert Koczulla, Robert Bals
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Cathelicidin LL-37: A Multitask Antimicrobial Peptide
Archivum Immunologiae et Therapiae Experimentalis, 2010The antimicrobial peptide LL-37 is the only known member of the cathelicidin family of peptides expressed in humans. LL-37 is a multifunctional host defense molecule essential for normal immune responses to infection and tissue injury. LL-37 peptide is a potent killer of different microorganisms with the ability to prevent immunostimulatory effects of ...
Robert, Bucki +3 more
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