Results 31 to 40 of about 191,378 (381)

Caspase-Mediated Cleavage of Human Cortactin during Influenza A Virus Infection Occurs in Its Actin-Binding Domains and Is Associated with Released Virus Titres

Viruses, 2020
Influenza A virus (IAV) exploits host factors to multiply and cause disease. An in-depth knowledge of this interaction of IAV with the host will aid the development of anti-IAV intervention strategies.
Da-Yuan Chen, Matloob Husain
doaj   +1 more source

Lysosomal Cathepsin Release Is Required for NLRP3-Inflammasome Activation by Mycobacterium tuberculosis in Infected Macrophages

Frontiers in Immunology, 2018
Lysosomal cathepsin B (CTSB) has been proposed to play a role in the induction of acute inflammation. We hypothesised that the presence of active CTSB in the cytosol is crucial for NLRP3-inflammasome assembly and, consequently, for mature IL-1β ...
Eduardo P. Amaral, N. Riteau, M. Moayeri, N. Maier, K. Mayer-Barber, R. M. Pereira, S. Lage, A. Kubler, W. Bishai, M. R. D’Império-Lima, A. Sher, B. Andrade   +11 more
semanticscholar   +1 more source

Exploring Extracellular Vesicles Biogenesis in Hypothalamic Cells through a Heavy Isotope Pulse/Trace Proteomic Approach

Cells, 2020
Studies have shown that the process of extracellular vesicles (EVs) secretion and lysosome status are linked. When the lysosome is under stress, the cells would secrete more EVs to maintain cellular homeostasis.
Chee Fan Tan, Hui San Teo, Jung Eun Park, Bamaprasad Dutta, Shun Wilford Tse, Melvin Khee-Shing Leow, Walter Wahli, Siu Kwan Sze   +7 more
doaj   +1 more source

Lysosomal-Cleavable Peptide Linkers in Antibody–Drug Conjugates

Biomedicines, 2023
Antibody–drug Conjugates (ADCs) are a powerful therapeutic modality for cancer treatment. ADCs are multi-functional biologics in which a disease-targeting antibody is conjugated to an effector payload molecule via a linker.
Seetharamsing Balamkundu, Chuan-Fa Liu
doaj   +1 more source

Human cathepsin H [PDF]

Biochemical Journal, 1980
Cathepsin H was purified from human liver by a method involving autolysis and acetone fractionation, and chromatography on DEAE-cellulose, Ultrogel AcA 54, hydroxyapatite and concanavalin A-Sepharose. The procedure allowed for the simultaneous isolation of cathepsin B and cathepsin D. Cathepsin H was shown to consist of a single polypeptide chain of 28
W N, Schwartz, A J, Barrett
openaire   +2 more sources

Elevated CTSL Gene Expression Correlated with Proinflammatory Cytokines in Omental Adipose Tissue of Patients with Obesity

Diabetes, Metabolic Syndrome and Obesity, 2022
Qiong Zhou,1,2 Yankun Zhu,3 Chun Li,2 Zhiqiang Li,1 Zhe Tang,2 Baohong Yuan,3 Xiaodan Wang,4 Shengqingyu Zhang,1 Xinan Wu1 1School of Public Health, Kunming Medical University, Kunming, People’s Republic of China; 2Department of Endocrinology, Yan’an ...
Zhou Q, Zhu Y, Li C, Li Z, Tang Z, Yuan B, Wang X, Zhang S, Wu X   +8 more
doaj  

Expression of Cathepsins B, D, and G in Isocitrate Dehydrogenase-Wildtype Glioblastoma

Frontiers in Surgery, 2017
AimTo investigate the expression of cathepsins B, D, and G, in relation to the cancer stem cell (CSC) subpopulations, we have previously characterized within isocitrate dehydogenase (IDH)-wildtype glioblastoma (IDHWGB).Methods3,3-Diaminobezidine (DAB ...
Sabrina P. Koh, Agadha C. Wickremesekera, Agadha C. Wickremesekera, Helen D. Brasch, Reginald Marsh, Swee T. Tan, Swee T. Tan, Tinte Itinteang   +7 more
doaj   +1 more source

Cleavage of Occludin by Cigarette Smoke-Elicited Cathepsin S Increases Permeability of Lung Epithelial Cells

Antioxidants, 2022
Background. Chronic obstructive pulmonary disease (COPD) is an irreversible disease mainly caused by smoking. COPD is characterized by emphysema and chronic bronchitis associated with enhanced epithelial permeability. Hypothesis.
Paul Bigot, Simon Chesseron, Ahlame Saidi, Damien Sizaret, Christelle Parent, Agnès Petit-Courty, Yves Courty, Fabien Lecaille, Gilles Lalmanach   +8 more
doaj   +1 more source

Cathepsin G and Its Role in Inflammation and Autoimmune Diseases.

Archives of Rheumatology, 2018
Cathepsin G belongs to the neutrophil serine proteases family, known for its function in killing pathogens. Studies over the past several years indicate that cathepsin G has important effects on inflammation and immune reaction, and may be a key factor ...
Siming Gao
semanticscholar   +1 more source

Glycopeptide Antibiotics Potently Inhibit Cathepsin L in the Late Endosome/Lysosome and Block the Entry of Ebola Virus, Middle East Respiratory Syndrome Coronavirus (MERS-CoV), and Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)

Journal of Biological Chemistry, 2016
Ebola virus infection can cause severe hemorrhagic fever with a high mortality in humans. The outbreaks of Ebola viruses in 2014 represented the most serious Ebola epidemics in history and greatly threatened public health worldwide.
Nan Zhou, T. Pan, Junsong Zhang, Qianwen Li, Xue Zhang, C. Bai, F. Huang, T. Peng, Jianhua Zhang, Chao Liu, L. Tao, Hui Zhang   +11 more
semanticscholar   +1 more source