Results 231 to 240 of about 13,268,265 (360)

Distinct Cleavage Properties of Cathepsin B Compared to Cysteine Cathepsins Enable the Design and Validation of a Specific Substrate for Cathepsin B over a Broad pH Range. [PDF]

Biochemistry, 2023
Yoon MC, Phan V, Podvin S, Mosier C, O'Donoghue AJ, Hook V.   +5 more
europepmc   +1 more source

Cathepsin B Knockout Mice Are Resistant to Tumor Necrosis Factor-α-Mediated Hepatocyte Apoptosis and Liver Injury [PDF]

, 2001
Maria Eugenia Guicciardi, Hideyuki Miyoshi, Steven F. Bronk, Gregory J. Gores   +3 more
openalex   +1 more source

Cathepsin B Regulates Ovarian Reserve Quality and Quantity via Mitophagy by Modulating IGF1R Turnover

Aging Cell, EarlyView.
Autophagy regulates ovarian reserve, with Cathepsin B playing a critical role in aging. Inhibition of Cathepsin B increases follicle count, enhances IGF1R–AKT–mTOR signaling and improves mitochondrial function without compromising fertility. This conserved mechanism suggests potential therapeutic strategies to delay ovarian aging and sustain fertility,
Aradhana Mohanty, Anjali Kumari, Lava Kumar. S, Ajith Kumar, Pravin Birajdar, Rohit Beniwal, Mohd Athar, Kiran Kumar. P, H.B.D.Prasada Rao   +8 more
wiley   +1 more source

Cathepsin B, L, and S Cleave and Inactivate Secretory Leucoprotease Inhibitor [PDF]

, 2001
Clifford C. Taggart, Gregory Lowe, Catherine M. Greene, Alan Mulgrew, Shane O’Neill, Rodney L. Levine, Noel G. McElvaney   +6 more
openalex   +1 more source

TFEB Orchestrates Stress Recovery and Paves the Way for Senescence Induction in Human Dermal Fibroblasts

Aging Cell, EarlyView.
TFEB dynamics during oxidative stress‐induced premature senescence. The tBHP treatment undermines GSH‐dependent antioxidant mechanisms, leading to increased ROS production and lysosomal damage. In the stress phase, we observed the concomitant inhibition of Akt along with activation of AMPK, together leading to mTOR inhibition and subsequent ...
Lena Guerrero‐Navarro, Pablo Monfort‐Lanzas, Vinzenz Krichbaumer, Mariana E. G. De Araújo, Jlenia Monfregola, Lukas A. Huber, Andrea Ballabio, Pidder Jansen‐Dürr, Maria Cavinato   +8 more
wiley   +1 more source

Linking oral microbial proteolysis to aMMP‐8 PoC diagnostics along with the stage and grade of periodontitis: A cross‐sectional study

, 2023
Oral Diseases, Volume 29, Issue 1, Page 285-289, January 2023.
Shipra Gupta, Vaibhav Sahni, Ismo T. Räisänen, Andreas Grigoriadis, Dimitra Sakellari, Dirk‐Rolf Gieselmann, Timo Sorsa   +6 more
wiley   +1 more source

Cathepsin B in cardiovascular disease: Underlying mechanisms and therapeutic strategies. [PDF]

J Cell Mol Med
Cai Z, Xu S, Liu C.
europepmc   +1 more source

Ar-turmerone inhibits the proliferation and mobility of glioma by downregulating cathepsin B. [PDF]

Aging (Albany NY), 2023
Cao W, Chen X, Xiao C, Lin D, Li Y, Luo S, Zeng Z, Sun B, Lei S.   +8 more
europepmc   +1 more source

Cathepsin B Activity Regulation [PDF]

, 2001
Paulo C. Almeida, Iseli L. Nantes, Jair R. Chagas, Cláudia C.A. Rizzi, Adelaide Faljoni‐Alário, Eurı́dice Carmona, Luiz Juliano, Helena B. Nader, Ivarne L.S. Tersariol   +8 more
openalex   +1 more source

TLR7 Mediates HIV‐1 Tat‐Induced Cellular Senescence in Human Astrocytes

Aging Cell, EarlyView.
Once internalized into endolysosomes, HIV‐1 Tat interacts and activates TLR7, causing endolysosome damage. Such interaction between HIV‐1 Tat and TLR7 also leads to a senescence‐like phenotype in astrocytes, including cell cycle arrest, elevated levels of p21 and p16 proteins, increased SA‐β‐gal activity, and enhanced secretion of SASP factors ...
Neda Rezagholizadeh, Gaurav Datta, Wendie A. Hasler, Erica C. Nguon, Elise V. Smokey, Xuesong Chen   +5 more
wiley   +1 more source