Results 261 to 270 of about 13,268,265 (360)

Exercise Delays Brain Ageing Through Muscle‐Brain Crosstalk

Cell Proliferation, EarlyView.
This graphical abstract illustrates the reciprocal crosstalk between the brain and peripheral organs, highlighting the profound impact of exercise on brain health through systemic interactions. It underscores how exercise influences the brain via signals from various organs and, conversely, how the brain modulates functions of peripheral organs.
Shirin Pourteymour, Rakesh Kumar Majhi, Frode A. Norheim, Christian A. Drevon   +3 more
wiley   +1 more source

Immunohistochemical Evaluation of Cathepsin B, L, and S Expression in Breast Cancer Patients. [PDF]

Mol Imaging Biol
Linders DGJ, Bijlstra OD, Fallert LC, Dekker-Ensink NG, March TL, Pool M, Walker E, Straight B, Basilion JP, Bogyo M, Burggraaf J, Hilling DE, Vahrmeijer AL, Kuppen PJK, Crobach ASLP.   +14 more
europepmc   +1 more source

TREM2 Impedes Recovery After Spinal Cord Injury by Regulating Microglial Lysosomal Membrane Permeabilization‐Mediated Autophagy

Cell Proliferation, EarlyView.
TREM2 exacerbates spinal cord injury by inhibiting TFEB nuclear translocation, aggravating lysosomal membrane permeabilisation and consequently suppressing autophagy. ABSTRACT Microglia, considered as the main immune responder, play an important role in regulating neuroinflammation in central nervous system (CNS) disorders. Our previous work found that
Tianlun Zhao, Jiawei Di, Yu Kang, Haojie Zhang, Senyu Yao, Bin Liu, Limin Rong   +6 more
wiley   +1 more source

Activation of Cytosolic Cathepsin B Activity in the Brain by Traumatic Brain Injury and Inhibition by the Neutral pH Selective Inhibitor Probe Z-Arg-Lys-AOMK. [PDF]

ACS Chem Neurosci
Podvin S, Florio J, Spencer B, Mante M, Guzman E, Arias C, Mosier C, Phan VV, Yoon MC, Almaliti J, O'Donoghue AJ, Gerwick WH, Rissman RA, Hook V.   +13 more
europepmc   +1 more source

Research Advances of the Autophagy‐Regulated Radiosensitivity

Cell Proliferation, EarlyView.
Autophagy plays a dual role in regulating cellular radiosensitivity in radiotherapy (RT). We discuss the mechanisms by which autophagy promotes survival and growthsuppression by modulating radiosensitivity. It also outlines some frontier autophagy‐targeted radiotherapies. ABSTRACT Autophagy is an evolutionarily conserved process of cell self‐catabolism
Hanyue Liu, Yanlan Xiao, Chuhao Dai, Keyu Chen, Xinyi Xu, Jianming Cai, Xuguang Hu, Jiaming Guo   +7 more
wiley   +1 more source

WF14865A and B, New Cathepsins B and L Inhibitors Produced by Aphanoascus fulvescens. I. Taxonomy, Production, Purification and Biological Properties.

, 2000
TAKANAO OTSUKA, Yuko Muramatsu, Tomoko Nakanishi, Hiroshi Hatanaka, Masanori Okamoto, Motohiro Hino, Seiji Hashimoto   +6 more
openalex   +2 more sources

Cathepsin B- and L-like Protease Activities Are Induced During Developmental Barley Leaf Senescence. [PDF]

Plants (Basel)
Schepetkin IA, Fischer AM.
europepmc   +1 more source

Cathepsin B contributes to Na+ hyperabsorption in cystic fibrosis airway epithelial cultures

Journal of Physiology, 2014
C. D. Tan, Carey A. Hobbs, M. Sameni, Bonnie F. Sloane, M. Stutts, R. Tarran   +5 more
semanticscholar   +1 more source

Proteomic associations with fluctuation and long‐term changes in BMI: A 40‐year follow‐up study

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Introduction While some studies have explored associations between weight change and blood proteins, most have been intervention‐based, offering limited insight into proteomic associations with long‐term weight gain. It remains unclear whether plasma proteins are related to BMI fluctuation over time.
Alvaro Obeso, Gabin Drouard, Teemu Palviainen, Xiaoling Wang, Miina Ollikainen, Karri Silventoinen, Jaakko Kaprio   +6 more
wiley   +1 more source

The cerebellum in epilepsy

Epilepsia, EarlyView.
Abstract The cerebellum, a subcortical structure, is traditionally linked to sensorimotor integration and coordination, although its role in cognition and affective behavior, as well as epilepsy, is increasingly recognized. Cerebellar dysfunction in patients with epilepsy can result from genetic disorders, antiseizure medications, seizures, and seizure‐
Christopher Elder, Rebecca Kerestes, Puneet Opal, Maria Marchese, Orrin Devinsky   +4 more
wiley   +1 more source