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Characterisation of Cathepsin B and Collagenolytic Cathepsin from Human Placenta [PDF]
European Journal of Biochemistry, 1978 1. Human placental cathepsin B and collagenolytic cathepsin were separated by chromatography on columns of Amberlite CG-50. Collagenolytic cathepsin was partially purified by chromatography on DEAE-Sephadex (A-50) and Sephadex G-100. Cathepsin B was purified by chromatography on CM-cellulose and Sephadex G-100. 2.
Patricia Evans, David J. Etherington
openaire +3 more sources
Cathepsin B Is Implicated in Triglyceride (TG)-Induced Cell Death of Macrophage
Korean Journal of Clinical Laboratory Science, 2020 Macrophage cell death contributes to the formation of plaque, leading to the development of atherosclerosis. The accumulation of triglyceride (TG) is also associated with the pathogenesis of atherosclerosis.
Byung Chul Jung +3 more
doaj +1 more source
Cathepsin B gene disruption induced Leishmania donovani proteome remodeling implies cathepsin B role in secretome regulation. [PDF]
PLoS ONE, 2013 Leishmania cysteine proteases are potential vaccine candidates and drug targets. To study the role of cathepsin B cysteine protease, we have generated and characterized cathepsin B null mutant L. donovani parasites. L.
Teklu Kuru Gerbaba, Lashitew Gedamu
doaj +1 more source
Cancer Research, 2017 Perineural invasion (PNI) is an ominous event strongly linked to poor clinical outcome. Cells residing within peripheral nerves collaborate with cancer cells to enable PNI, but the contributing conditions within the tumor microenvironment are not well ...
R. Bakst +19 more
semanticscholar +1 more source
Parasites & Vectors, 2019 Background Three main enzymes including cathepsin B, cathepsin D and acid phosphatase are involved in vitellin degradation, which is a major biochemical event of the embryonic development and can provide nutrients and metabolites for tick embryos. In the
Tian-Tian Zhang +6 more
doaj +1 more source
Cathepsin B launches an apoptotic exit effort upon cell death-associated disruption of lysosomes
Cell Death Discovery, 2016 The release of cathepsin proteases from disrupted lysosomes results in lethal cellular autodigestion. Lysosomal disruption-related cell death is highly variable, showing both apoptotic and necrotic outcomes.
M. de Castro, G. Bunt, FS Wouters
semanticscholar +1 more source
Expression of Cathepsins B, D, and G in WHO Grade I Meningioma
Frontiers in Surgery, 2019 Aim: We have recently demonstrated the presence of putative tumor stem cells (TSCs) in World Health Organization (WHO) grade I meningioma (MG) localized to the microvessels, which expresses components of the renin-angiotensin system (RAS).
Rosanna M. A. Rahman +12 more
doaj +1 more source
Release of Cathepsin B in Cytosol Causes Cell Death in Acute Pancreatitis.
Gastroenterology, 2016 BACKGROUND & AIMS Experimental studies in acute pancreatitis (AP) suggest a strong association of acinar cell injury with cathepsin B-dependent intracellular activation of trypsin.
R. Talukdar +14 more
semanticscholar +1 more source
Circadian modulation of microglial physiological processes and immune responses
Glia, Volume 71, Issue 2, Page 155-167, February 2023., 2023 Main Points Microglia are rhythmic cells with an oscillatory expression in clock genes, cytokines, and other microglial markers. Microglial circadian rhythms determine their physiological function and immune responses. Abstract Microglia is considered the central nervous system (CNS) resident macrophages that establish an innate immune response against
Mara A. Guzmán‐Ruiz +11 more
wiley +1 more source
BMC Oral Health, 2022 Background Oral cancer is considered a major public health problem due to its high mortality and morbidity rates. Survival rate of OSCC can be significantly improved by using non-invasive tool such as salivary biomarkers for detection of OSCC which is ...
Alveena Shabbir +4 more
doaj +1 more source