Results 91 to 100 of about 66,677 (282)

Cell‐Free DNA‐Based Theranostics for Inflammatory Disorders

Advanced Science, EarlyView.
Summary on the dual potential of cfDNA as biomarkers and therapeutic targets for inflammatory disorders. Figure was created with BioRender.com. ABSTRACT Inflammatory disorders are characterized by immune‐mediated inflammatory cascades that can affect multiple organs.
Jiatong Li, Yumei Wang, Xiaoxi Fan, Miao Xu, Jiawen Li, Wenfei Tan, Jianxiang Zhang, Heran Li   +7 more
wiley   +1 more source

Artificial Intelligence for Bone: Theory, Methods, and Applications

Advanced Intelligent Discovery, EarlyView.
Advances in artificial intelligence (AI) offer the potential to improve bone research. The current review explores the contributions of AI to pathological study, biomarker discovery, drug design, and clinical diagnosis and prognosis of bone diseases. We envision that AI‐driven methodologies will enable identifying novel targets for drugs discovery. The
Dongfeng Yuan, Haicang Zhang, Liping Tong, Di Chen   +3 more
wiley   +1 more source

Neurofilament Proteoforms in Amyotrophic Lateral Sclerosis Are Different in Cerebrospinal Fluid and Blood

Annals of Neurology, EarlyView.
We used targeted immunopurification‐mass spectrometry (IP‐MS) to characterize human neurofilament light chain (NfL) proteoforms across various compartments to assess their alterations in amyotrophic lateral sclerosis (ALS). NfL is truncated in cerebrospinal fluid (CSF) and blood in patients with sporadic ALS (sALS) and these proteoforms differ between ...
John B. Coulton, Yingxin He, Melissa M. Budelier, Nicolas Barthélemy, Margaret D. Ireland, Miwei Hu, Danielle Graham, Toby Ferguson, James D. Berry, Randall J. Bateman, Timothy M. Miller, Cindy V. Ly   +11 more
wiley   +1 more source

Complementaktivierung durch Cathepsin D

, 2016
Nach einem Polytrauma wird das Complementsystem aktiviert mit Bildung der Anaphylatoxine C3a und C5a. Auch die Apoptose wird induziert, um der generalisierten Entzündung entgegenzuwirken. In der vorliegenden Arbeit konnten in vitro durch die proapoptotische Aspartatprotease Cathepsin D konzentrations- und zeitabhängig die Anaphylatoxine C3a und C5a ...
openaire   +2 more sources

Cathepsin D and its newly identified transport receptor SEZ6L2 can modulate neurite outgrowth [PDF]

, 2015
Marielle Boonen, Catherine Staudt, Florentine Gilis, Viola Oorschot, Judith Klumperman, Michel Jadot   +5 more
openalex   +1 more source

Data from AGR2 Is a Novel Surface Antigen That Promotes the Dissemination of Pancreatic Cancer Cells through Regulation of Cathepsins B and D

, 2023
Laurent Dumartin, Hannah J. Whiteman, Mark C. Willingham, Deepak Hariharan, Branko Dmitrović, Christine A. Iacobuzio–Donahue, Teresa A. Brentnall, Mary P. Bronner, Roger Feakins, John F. Timms, Caroline H. Brennan, Nicholas R. Lemoine, Tatjana Crnogorac‐Jurcevic   +12 more
openalex   +1 more source

Neuroprotective Effects of Methyl Caffeate against Hydrogen Peroxide-Induced Cell Damage: Involvement of Caspase 3 and Cathepsin D Inhibition [PDF]

, 2020
Danuta Jantas, Jakub Chwastek, Janusz Malarz, Anna Stojakowska, Władysław Lasoń   +4 more
openalex   +1 more source

Lack of Cathepsin D in the central nervous system results in microglia and astrocyte activation and the accumulation of proteinopathy-related proteins [PDF]

, 2022
Chigure Suzuki, Junji Yamaguchi, Takahito Sanada, Juan Alejandro Oliva Trejo, Souichirou Kakuta, Masahiro Shibata, Isei Tanida, Yasuo Uchiyama   +7 more
openalex   +1 more source

Plasma Proteomics Identifies TAOK3 as a Potential Biomarker of Rheumatoid Arthritis Activity and a Novel Therapeutic Target

Arthritis &Rheumatology, Accepted Article.
Objective Bone destruction associated with active rheumatoid arthritis (RA) remains a major therapeutic challenge, with a lack of reliable molecular markers reflecting bone injury. This study aims to identify novel biomarkers linked to bone destruction in active RA through proteomic analysis, providing new strategies for precise monitoring and targeted
Pengfei Xin, Wenzhen Li, Xinyu A, Jun Shen, Xiaohui Meng, Yanqin Bian, Haihui Han, Zheng Xiang, Lei Ran, Songtao Sun, Jun Xie, Tao Yue, Qi Zhu, Xiaoming Zhang, Lu Xie, Lianbo Xiao   +15 more
wiley   +1 more source

The Expression of Multiple Proteins as Prognostic Factors in Colorectal Cancer: Cathepsin D, p53, COX-2, Epidermal Growth Factor Receptor, C-erbB-2, and Ki-67

Gut and Liver, 2014
Background/AimsA single gene mutation alone cannot explain the poor prognosis of colorectal cancer. This study aimed to establish a correlation between the expression of six proteins and the prognosis of colorectal cancer patients.Methods : Tissue ...
doaj   +1 more source