Yeast as a tool to explore cathepsin D function [PDF]
Microbial Cell, 2015 Cathepsin D has garnered increased attention in recent years, mainly since it has been associated with several human pathologies. In particular, cathepsin D is often overexpressed and hypersecreted in cancer cells, implying it may ...
H. Pereira +5 more
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Lysosomal dysfunction promotes cleavage and neurotoxicity of tau in vivo. [PDF]
PLoS Genetics, 2010 Expansion of the lysosomal system, including cathepsin D upregulation, is an early and prominent finding in Alzheimer's disease brain. Cell culture studies, however, have provided differing perspectives on the lysosomal connection to Alzheimer's disease,
Vikram Khurana +8 more
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Journal of Dairy Science, 2023 : The bovine endopeptidase cathepsin D was investigated regarding its temperature-dependent inactivation and ability to form bitter peptides within a spiked model fresh cheese.
Gudrun Horstmann +5 more
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Status and future directions of anti-metastatic cancer nanomedicines for the inhibition of cathepsin L [PDF]
, 2020 Angiogenesis, tissue invasion and metastasis in the tumour microenvironment are all critical hallmarks of cancer. Upregulation of cathepsin L plays an important role in angiogenesis and metastasis through its ability to degrade the extracellular matrix ...
Pranjol, Md Zahidul I +3 more
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Folia Histochemica et Cytobiologica, 2012 We studied the effect of heavy metal cations: Fe 2+, Cu2+, Zn2+, Cd2+, Hg2+, Pb2+ on the activity of<br />cathepsin D in human aorta homogenate and blood serum. The concentration of cations was 1 mmol/l.
Alicja Karwowska +5 more
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The Role of Cathepsin D in the Pathophysiology of Heart Failure and its Potentially Beneficial Properties:a translational approach [PDF]
, 2019 Aims: Cathepsin D is a ubiquitous lysosomal protease that is primarily secreted due to oxidative stress. The role of circulating cathepsin D in heart failure (HF) is unknown.
Adriaan A. Voors +16 more
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Haematopoietic development and immunological function in the absence of cathepsin D
BMC Immunology, 2007 Background Cathepsin D is a well-characterized aspartic protease expressed ubiquitously in lysosomes. Cathepsin D deficiency is associated with a spectrum of pathologies leading ultimately to death.
Saftig Paul +5 more
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Immunoradiometric assay of cathepsin D: Estrogen regulated vs. non estrogen- regulated cathepsin D expression in relation to clinicopathological features of breast cancer [PDF]
Archive of Oncology, 2002 Background: Cellular biomarkers may predict tumor cell behavior in breast cancer. One of the most paradoxical biomarker in breast cancer is cathepsin D.
Nikolić-Vukosavljević Dragica +4 more
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Immune-Mediated Inflammation May Contribute to the Pathogenesis of Cardiovascular Disease in Mucopolysaccharidosis Type I. [PDF]
, 2016 BackgroundCardiovascular disease, a progressive manifestation of α-L-iduronidase deficiency or mucopolysaccharidosis type I, continues in patients both untreated and treated with hematopoietic stem cell transplantation or intravenous enzyme replacement ...
Dickson, Patricia I +7 more
core +13 more sources
Neurobiology of Disease, 2020 The presence of GBA1 gene mutations increases risk for Parkinson's disease (PD), but the pathogenic mechanisms of GBA1 associated PD remain unknown. Given that impaired α-synuclein turnover is a hallmark of PD pathogenesis and cathepsin D is a key enzyme
Shi-yu Yang +3 more
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