Results 11 to 20 of about 66,677 (282)

Association of LVV-Hemorphin-7 with Sepsis and Shock: Roles of Cathepsin D and G in Hemoglobin Metabolism in a Prospective ICU Cohort Study [PDF]

Biomedicines
Background: Sepsis is a leading cause of mortality in intensive care units (ICUs). Cell-free hemoglobin (CFH) released during sepsis interacts with lysosomal enzymes from neutrophils and macrophages.
Yao-Kuang Wu, Hsueh-Wen Chung, Yi-Ting Chen, Hsing-Chun Chen, I-Hung Chen, Wen-Lin Su   +5 more
doaj   +2 more sources

Cathepsin-D and outcomes in peripartum cardiomyopathy: Results from IPAC. [PDF]

Am Heart J Plus
Polsinelli VB, Hanley-Yanez K, McTiernan CF, Modi K, Haythe J, Skopicki H, Elkayam U, Cooper LT, Fett JD, McNamara DM, IPAC investigators.   +10 more
europepmc   +2 more sources

Lysosomal dysfunction promotes cleavage and neurotoxicity of tau in vivo. [PDF]

PLoS Genetics, 2010
Expansion of the lysosomal system, including cathepsin D upregulation, is an early and prominent finding in Alzheimer's disease brain. Cell culture studies, however, have provided differing perspectives on the lysosomal connection to Alzheimer's disease,
Vikram Khurana, Ilan Elson-Schwab, Tudor A Fulga, Katherine A Sharp, Carin A Loewen, Erin Mulkearns, Jaana Tyynelä, Clemens R Scherzer, Mel B Feany   +8 more
doaj   +1 more source

The behavior of cathepsin D during milk processing and its contribution to bitterness in a model fresh cheese

Journal of Dairy Science, 2023
: The bovine endopeptidase cathepsin D was investigated regarding its temperature-dependent inactivation and ability to form bitter peptides within a spiked model fresh cheese.
Gudrun Horstmann, Johannes Schäfer, Melanie Rosenberger, Ines Seitl, Jörg Hinrichs, Lutz Fischer   +5 more
doaj   +1 more source

Effect of heavy metal cations on the activity of cathepsin D (in vitro study) Effect of heavy metal cations on the activity of cathepsin D (in vitro study)

Folia Histochemica et Cytobiologica, 2012
We studied the effect of heavy metal cations: Fe 2+, Cu2+, Zn2+, Cd2+, Hg2+, Pb2+ on the activity of<br />cathepsin D in human aorta homogenate and blood serum. The concentration of cations was 1 mmol/l.
Alicja Karwowska, Radosław Łapiński, Marek Gacko, Ewa Grzegorczyk, Joanna Żurawska, Jan K. Karczewski   +5 more
doaj   +1 more source

Yeast as a tool to explore cathepsin D function

Microbial Cell, 2015
Cathepsin D has garnered increased attention in recent years, mainly since it has been associated with several human pathologies. In particular, cathepsin D is often overexpressed and hypersecreted in cancer cells, implying it may ...
H. Pereira, C.S.F. Oliveira, L. Castro, A. Preto, S. R. Chaves, M. Côrte-Real   +5 more
doaj   +1 more source

Immunoradiometric assay of cathepsin D: Estrogen regulated vs. non estrogen- regulated cathepsin D expression in relation to clinicopathological features of breast cancer [PDF]

Archive of Oncology, 2002
Background: Cellular biomarkers may predict tumor cell behavior in breast cancer. One of the most paradoxical biomarker in breast cancer is cathepsin D.
Nikolić-Vukosavljević Dragica, Markičević Milan, Kanjer Ksenija, Raković-Todorović Nataša, Nešković-Konstantinović Zora   +4 more
doaj   +1 more source

Haematopoietic development and immunological function in the absence of cathepsin D

BMC Immunology, 2007
Background Cathepsin D is a well-characterized aspartic protease expressed ubiquitously in lysosomes. Cathepsin D deficiency is associated with a spectrum of pathologies leading ultimately to death.
Saftig Paul, Grosvenor Nicholas, Novelli Marco, Uchiyama Yasuo, Tulone Calogero, Chain Benjamin M   +5 more
doaj   +1 more source

Pro-cathepsin D as a diagnostic marker in differentiating malignant from benign pleural effusion: a retrospective cohort study

BMC Cancer, 2020
Background Malignant pleural effusion (MPE) causes substantial symptomatic burden in advanced malignancy. Although pleural fluid cytology is a commonly accepted gold standard of diagnosis, its low diagnostic yield is a challenge for clinicians.
Hayoung Choi, Yousang Ko, Chang Youl Lee
doaj   +1 more source

A cardinal role for cathepsin d in co-ordinating the host-mediated apoptosis of macrophages and killing of pneumococci. [PDF]

PLoS Pathogens, 2011
The bactericidal function of macrophages against pneumococci is enhanced by their apoptotic demise, which is controlled by the anti-apoptotic protein Mcl-1.
Martin A Bewley, Helen M Marriott, Calogero Tulone, Sheila E Francis, Timothy J Mitchell, Robert C Read, Benny Chain, Guido Kroemer, Moira K B Whyte, David H Dockrell   +9 more
doaj   +1 more source