Results 201 to 210 of about 113,729 (277)

Periodontitis and rheumatoid arthritis—Global efforts to untangle two complex diseases

Periodontology 2000, EarlyView.
Abstract Understanding the impact of oral health on rheumatoid arthritis (RA) will inform how best to manage patients with both periodontitis and RA. This review seeks to provide an update on interventional and mechanistic investigations, including a brief summary of European Research programs investigating the link between periodontitis and RA. Recent
Isabel Lopez‐Oliva, Jennifer Malcolm, Shauna Culshaw   +2 more
wiley   +1 more source

Targeted demethylation of cathepsin D via epigenome editing rescues pathology in Alzheimer's disease mouse model. [PDF]

Theranostics
Park M, Ryu H, Heo S, Kim B, Park J, Lim KH, Han SB, Park H.   +7 more
europepmc   +1 more source

Inflammation and mechanical force‐induced bone remodeling

Periodontology 2000, EarlyView.
Abstract Periodontitis arises from imbalanced host–microbe interactions, leading to dysbiosis and destructive inflammation. The host's innate and adaptive immune responses produce pro‐inflammatory mediators that stimulate destructive events, which cause loss of alveolar bone and connective tissue attachment.
Hyeran Helen Jeon, Xin Huang, Leticia Rojas Cortez, Puttipong Sripinun, Jung‐me Lee, Julie J. Hong, Dana T. Graves   +6 more
wiley   +1 more source

Inhibition of intracellular versus extracellular cathepsin D differentially alters the liver lipidome of mice with metabolic dysfunction-associated steatohepatitis. [PDF]

FEBS J
Vermeulen I, Li M, van Mourik H, Yadati T, Eijkel G, Balluff B, Godschalk R, Temmerman L, Biessen EAL, Kulkarni A, Theys J, Houben T, Cillero-Pastor B, Shiri-Sverdlov R.   +13 more
europepmc   +1 more source

Genetic risk variants implicate impaired maintenance and repair of periodontal tissues as causal for periodontitis—A synthesis of recent findings

Periodontology 2000, EarlyView.
AbstractPeriodontitis is a complex inflammatory disease in which the host genome, in conjunction with extrinsic factors, determines susceptibility and progression. Genetic predisposition is the strongest risk factor in the first decades of life. As people age, chronic exposure to the periodontal microbiome puts a strain on the proper maintenance of ...
Arne S. Schaefer, Luigi Nibali, Noha Zoheir, Niki M. Moutsopoulos, Bruno G. Loos   +4 more
wiley   +1 more source

Scutellarin ameliorates ischemia/reperfusion-mediated endothelial dysfunction by upregulating cathepsin D expression to rescue autophagy-lysosomal function. [PDF]

Front Pharmacol
Zhuang Q, Chen L, Wu W, Wang Q, Kang C, Xiong Y, Huang X.   +6 more
europepmc   +1 more source

Advantages of horizontal centrifugation of platelet‐rich fibrin in regenerative medicine and dentistry

Periodontology 2000, EarlyView.
Abstract The aim of this comprehensive review was to evaluate comparative studies on horizontal and fixed‐angle centrifugation methods for preparing platelet‐rich fibrin (PRF). Furthermore, additional studies utilizing horizontal PRF (H‐PRF) were systematically investigated.
Nima Farshidfar, Karol Alí Apaza Alccayhuaman, Nathan E. Estrin, Paras Ahmad, Anton Sculean, Yufeng Zhang, Richard J. Miron   +6 more
wiley   +1 more source

Impaired cathepsin D in retinal pigment epithelium cells mediates Stargardt disease pathogenesis. [PDF]

FASEB J
Ng ESY, Hu J, Jiang Z, Radu RA.
europepmc   +1 more source

Biological definition of periodontal diseases: A historical review of host‐response diagnostics and their implications for disease classification

Periodontology 2000, EarlyView.
Abstract Background Understanding periodontal diseases through a biological lens has been a central aim in periodontal research. Visionary pioneers in the field established the foundations of our knowledge, providing invaluable insights into disease mechanisms and progression.
Nagihan Bostanci, Melissa M. Grant, Moritz Kebschull   +2 more
wiley   +1 more source

Plasma cathepsin D as an early indicator of alcohol-related liver disease. [PDF]

JHEP Rep
Li M, Houben T, Bitorina AV, Meesters DM, Israelsen M, Kjærgaard M, Koek GH, Hendrikx T, Verbeek J, Krag A, Thiele M, Shiri-Sverdlov R.   +11 more
europepmc   +1 more source