Results 81 to 90 of about 66,677 (282)

Endothelial Cell‐Specific Molecule‐1 (ESM1): An Endogenous Anticoagulant and Protective Factor in Venous Thrombosis

Advanced Science, EarlyView.
This study identifies ESM1 as an endogenous anticoagulant that modulates venous thrombosis. It shows that ESM1 deficiency triggers vascular occlusion in zebrafish and mice, whereas its restoration or overexpression prolongs clot‐formation time. Mechanistic analyses reveal that ESM1 activates HCII through its dermatan‐sulfate chain, uncovering a ...
Changsheng Chen, Xiaojuan Ge, Dongxu Fu, Haijun Mei, Feng Lv, Chao Yang, Jiahao Lu, Xiaozhong Shen, Bowen Li, Xiaoning Wang, Dong Liu   +10 more
wiley   +1 more source

Proteomic Analysis of Circulating Monocytes Identifies Cathepsin D as A Potential Novel Plasma Marker of Acute Coronary Syndromes

Clinical Medicine Insights: Cardiology, 2008
We have performed a proteomic analysis of peripheral blood monocytes from ACS patients in comparison with healthy subjects and stable coronary patients in order to search novel biomarkers of ACS in circulating monocytes.
Maria G. Barderas, Veróica M. Dardé, Fernando de la Cuesta, Jose Luis Martin-Ventura, Luis Miguel Blanco-Colio, Julio Jiménez-Narcher, Gloria Alvarez-Llamas, Lorenzo Lopez-Bescos, José Tuñó, Jesús Egido, Fernando Vivanco   +10 more
doaj   +1 more source

Ligand‐Induced Electronic Response Enables Predictive QM/MM Simulations

Advanced Science, EarlyView.
Quantum mechanics/molecular mechanics (QM/MM) simulations are powerful tools for modeling complex molecular systems; however, their predictability has been constrained by the ambiguous definition of the QM region. An electronically informed protocol is introduced that defines QM regions by quantifying guest‐induced orbital shifts and charge ...
Nichika Ozawa, Nahoko Kuroki, Hirotoshi Mori   +2 more
wiley   +1 more source

Cathepsin D deficiency induces cytoskeletal changes and affects cell migration pathways in the brain

Neurobiology of Disease, 2013
Cathepsin D deficiency is a fatal neurodegenerative disease characterized by extreme loss of neurons and myelin. Our previous studies have demonstrated that structural and functional alterations in synapses are central to the disease pathogenesis ...
Sabine Koch, Enzo Scifo, Anne Rokka, Pascal Trippner, Maria Lindfors, Reeta Korhonen, Garry L. Corthals, Ismo Virtanen, Maciej Lalowski, Jaana Tyynelä   +9 more
doaj   +1 more source

Identification of a Force‐Induced Sox9+Acan+ Transitional Subpopulation Linked to FGF2–FGFR2–ERK Signaling in Orthodontic Bone Remodeling

Advanced Science, EarlyView.
Mechanical loading induces a previously unrecognized Sox9+Acan+ transitional mesenchymal cell population in the periodontal ligament that promotes osteoclastogenesis via the FGF2–FGFR2–ERK axis. Targeting this mechanoresponsive stromal population using a localized GelMA@siRNA delivery strategy attenuates pathological osteoclast overactivation and root ...
Miao Tan, Minyu He, Mingrui Zong, Qiya Tang, Yinan Liu, Jiaju Deng, Shun Huang, Xiaoxiao Lei, Jie Li, Lan Huang   +9 more
wiley   +1 more source

Neuropathological changes in scrapie and Alzheimer's disease are associated with increased expression of apolipoprotein E and cathepsin D in astrocytes [PDF]

, 1991
J.F. Diedrich, Hal Minnigan, Richard I. Carp, John N. Whitaker, Richard Race, William H. Frey, Ashley T. Haase   +6 more
openalex   +1 more source

Data from The Role of S100P in the Invasion of Pancreatic Cancer Cells Is Mediated through Cytoskeletal Changes and Regulation of Cathepsin D

, 2023
Hannah J. Whiteman, Mark C. Willingham, Sally E. Dowen, Sayka Barry, John F. Timms, Nicholas R. Lemoine, Tatjana Crnogorac‐Jurcevic   +6 more
openalex   +1 more source

Direct Extracellular Matrix Modulation Attenuates Intestinal Fibrosis via a Fibronectin‐Targeted Approach

Advanced Science, EarlyView.
Fibronectin regulates the extracellular matrix (ECM)–myofibroblast cycle through three key steps: (1) its secretion and assembly by myofibroblasts (inhibited by pUR4); (2) collagen deposition along its scaffold (inhibited by R1R2); and (3) integrin α5β1‐mediated mechanotransduction (inhibited by ATN161).
Wenlong Ma, Siyu Yang, Tengkai Wang, Di Zhang, Hewei Wu, Shichen Fu, Xiaohan Wan, Lixiang Li, Xiuli Zuo, Yanqing Li, Jiaoyang Lu   +10 more
wiley   +1 more source

Cathepsin L Promotes Vascular Intimal Hyperplasia after Arterial Injury

Molecular Medicine, 2017
The inflammatory pathways that drive the development of intimai hyperplasia (IH) following arterial injury are not fully understood. We hypothesized that the lysosomal cysteine protease cathepsin L activates processes leading to IH after arterial injury.
Jingjing Cai, Hua Zhong, Jinze Wu, Rui-Fang Chen, Huan Yang, Yousef Al-Abed, Ying Li, Xiaohui Li, Weihong Jiang, Marcelo F. Montenegro, Hong Yuan, Timothy R. Billiar, Alex F. Chen   +12 more
doaj   +1 more source

Cathepsin D Expression in Colorectal Adenocarcinomas and Adenomas [PDF]

, 2002
Yonca Kanber, Nilgün Demirbağ, Albert D. Sam, Nasuhi Engin Aydın   +3 more
openalex   +1 more source