Results 101 to 110 of about 11,881,546 (284)

Neutrophil Cathepsin G Increases Transendothelial Albumin Flux

, 1989
Neutrophlls are involved in the development of inflammatory edema in some animal models, but their mechanisms of action are not completely understood. Among injurious agents available for neutrophil-mediated injury are cationic proteins such as cathepsin
Peterson, Michael W.
core   +1 more source

Neutrophil cathepsin G enhances human platelet aggregation.

, 2013
A. Platelet aggregation in response to thrombin receptor activating peptide (TRAP) was determined by impedance aggregometry in platelet rich plasma (PRP) in the presence (5×103 neutrophils/µl) and absence of polymorphonuclear neutrophils (PMN) and ...
Nauder Faraday (414381), Craig Morrell (441823), Kathryn Schunke (441820), Sylvain Dore (441824), Bing Wang (126120), Juan Fu (441822), Sofiyan Saleem (441821), Jian Zhang (1682)   +7 more
core   +1 more source

In Situ Bioorthogonal Synthesis of PROTACs via Dual‐Responsive Cleavage for Synergistic Photo‐Immunotherapy

Advanced Science, EarlyView.
A bioactive self‐delivering SNAP‐TAC platform responds to tumor‐associated cathepsin B and glutathione, enabling in situ bioorthogonal synthesis of a BRD4‐degrading proteolysis‐targeting chimera within the tumor microenvironment. The resulting BRD4 degradation and PD‐L1 downregulation synergize with photodynamic therapy‐induced immunogenic cell death ...
Shiqin Jian, Jiasha Wu, Fusheng Xu, Yan Zuo, Huaxing Shen, Rui Ji, Luyi Wang, Na Li, Yanting Sun, Yongsheng Yu, Yejiao Shi, Honggang Hu, Feng Xu, Dan Huang, Xiaochun Hu   +14 more
wiley   +1 more source

LAPTM5 Downregulation‐Driven VAMP8 Phosphorylation Impairs Autophagosome‐Lysosome Fusion and Aggravates Septic Acute Lung Injury

Advanced Science, EarlyView.
LAPTM5 functions as a critical molecular scaffold bridging PGAM5 and VAMP to facilitate PGAM5‐mediated dephosphorylation of VAMP8. This cascade promotes autophagosome‐lysosome fusion, restores impaired autophagic flux, and clears damaged mitochondria, thereby mitigating cellular oxidative stress and systemic inflammation.
Lang Jiang, Qilan Li, Hao Liu, Xuehui Gao, Hongyu Nie, Lang Chen, Mei He, Xuefeng Li, Xiangming Fang, Jiqian Xu, Hao Zhang, Jiahong Xia, You Shang   +12 more
wiley   +1 more source

Cathepsin G and thrombin: evidence for two different platelet receptors

, 1994
Neutrophil cathepsin G and thrombin, the only platelet agonists that are proteases, exhibit a mandatory requirement for catalytic activity to induce platelet aggregation and signal transduction. The thrombin receptor is a G-protein-coupled receptor which
Selak, Mary A
core   +1 more source

The Role of Neutrophil Proteins on the Amyloid Beta-RAGE Axis.

PLoS ONE, 2016
We previously showed an elevated expression of the neutrophil protein, cationic antimicrobial protein of 37kDa (CAP37), in brains of patients with Alzheimer's disease (AD), suggesting that CAP37 could be involved in AD pathogenesis.
Amanda J Stock, Anne Kasus-Jacobi, Jonathan D Wren, Virginie H Sjoelund, Glenn D Prestwich, H Anne Pereira   +5 more
doaj   +1 more source

β‐Adducin Restrains PLA2G4A‐Dependent Lysosomal Membrane Permeabilization and Neuronal Death in Ischemic Stroke

Advanced Science, EarlyView.
This study identifies β‐adducin as a regulator of lysosomal integrity in ischemic neurons. Ischemia‐associated FTO loss increases m6A modification and destabilizes Add2 mRNA, reducing β‐adducin expression and promoting PLA2G4A accumulation at lysosomes.
Hui‐qin Li, Pin‐yi Liu, Dan Wu, Fei‐yu Ma, Yi Bai, Sheng‐nan Xia, Hai‐yan Yang, Xin‐yu Bao, Yun Xu, Xiang Cao   +9 more
wiley   +1 more source

Neutrophil cathepsin G is specifically decreased under vitamin A deficiency [PDF]

, 1996
Vitamin A deficiency leads to an increased susceptibility to infections, increased severity of infections and increased mortality. Because the neutrophil is the first cell to respond to infection, this study explores the effect of vitamin A deficiency on
Twining, Sally S., Zhou, Xiaoye, Moulder, John E., Fish, Brian L., Schulte, David P., Wilson, Patricia M.   +5 more
core   +1 more source

Downregulation of interleukin 36γ and its cleaver cathepsin G following treatment with narrow-band ultraviolet B phototherapy in psoriasis vulgaris

, 2022
Background Growing evidence suggests the important role of IL-36 in the pathogenesis of psoriasis. Cathepsin G is a neutrophil-derived protease that can activate IL-36γ.
Mona El-Kalioby, Laila A. Rashed, Eman R. Said, Mohamed H. M. EL-Komy, Dina G. Saadi, Faisal Nouredin Mohammed, Eman D. El Desouky, Marwa Ahmed Amer, Aya M. AlOrbani   +8 more
core   +1 more source

Eryptotic Phenotype in Chronic Myeloid Leukemia: Contribution of Neutrophilic Cathepsin G

Anemia, 2012
In pathological conditions with concurrent neutrophilia, modifications of erythrocyte membrane proteins are reported. In chronic myeloid leukemia (CML), a myeloproliferative disease wherein neutrophilia is accompanied by enhanced erythrophagocytosis, we ...
Rukmini Govekar, Poonam Kawle, Renjan Thomas, Suresh Advani, Sheena PV, Surekha Zingde   +5 more
doaj   +1 more source