Results 131 to 140 of about 11,881,546 (284)

Single-cell analysis reveals melanocytes may promote inflammation in chronic wounds through cathepsin G. [PDF]

Front Genet, 2023
Yakupu A, Zhang D, Guan H, Jiang M, Dong J, Niu Y, Tang J, Liu Y, Ma X, Lu S.   +9 more
europepmc   +1 more source

DNA-based aptamers for human cathepsin G

, 2010
The present research is directed to the identification of non-peptidic inhibitors of cathepsin G characterised by high levels of selectivity and which can be efficaciously used in the treatment and prophylaxis of inflammatory occurrences and procoagulant
Ferro Laura Iris, Porta Roberto, Pescador Rodolfo, PALUMBO, MANLIO, GATTO, BARBARA   +4 more
core  

Thrombin and cathepsin G do not contribute to apoE proteolysis in conditioned neuronal medium.

, 2014
A) Rec apoE4 (2 ug) was incubated together with purified human thrombin (5 U) in presence and absence of direct thrombin inhibitor argotroban (AGTB) at indicated concentrations for 16 h at 37°C. Since AGTB was dissolved in DMSO, DMSO control was included.
Irfan Y. Tamboli (543932), G. William Rebeck (230144), Dongeun Heo (543933)   +2 more
core   +1 more source

Turning Bonding Into Function: The Emerging Role of the Bioactive Selenium─Metal Motif in Toxicology and Medicinal Chemistry

Chemistry – A European Journal, EarlyView.
Balancing Act: Se─M bond serving as the fulcrum of the balance scale to compare the different weight of toxicity and therapeutic effects in biological environment. ABSTRACT The synthesis and characterization of organo‐selenium compounds have attracted considerable interest for decades, driven by the search for efficient catalysts and bioinspired ...
Matteo Filippi, Alessandro Rubbi, Pablo A. Nogara, Giovanni Ribaudo, Vito Lippolis, João B. T. Rocha, Laura Orian   +6 more
wiley   +1 more source

MurNAc‐Based Electrophilic Inhibitors of O‐Acetylpeptidoglycan Esterase (Ape): Design, Synthesis, and Kinetic Evaluation

Chemistry – A European Journal, EarlyView.
A series of N‐acetylmuramic acid (MurNAc)‐based electrophilic inhibitors targeting Ape esterase was synthesized. Their inhibitory potency ranged from micromolar to submillimolar. The study probed binding contributions of stem peptide extension, replacing the anomeric methyl group with a benzyl, and α‐fluorination of the carbonyl to enhance ...
Dmytro Voskoboinyk, Martin E. Tanner
wiley   +1 more source

Bidirectional two-sample Mendelian randomization analysis investigates causal associations between cathepsins and inflammatory bowel disease

Frontiers in Genetics
BackgroundCathepsins, key regulators of the pathology of gastrointestinal disorders such as inflammatory bowel disease (IBD), are a target protease that has attracted much attention in recent years. IBD is a chronic and relapsing inflammatory disorder of
Na Wang, Jun Liu, Bao Chai, Jianhong Yao, Xufang Du, Qi Mei, Xuena Wang   +6 more
doaj   +1 more source

Neutrophil cathepsin G proteolysis of protease-activated receptor 4 generates a novel, functional tethered ligand. [PDF]

Blood Adv, 2022
Stoller ML, Basak I, Denorme F, Rowley JW, Alsobrooks J, Parsawar K, Nieman MT, Yost CC, Hamilton JR, Bray PF, Campbell RA.   +10 more
europepmc   +1 more source

Amniotic fluid cathepsin-G in pregnancies complicated by the preterm prelabor rupture of membranes

, 2017
The aim of this study was to evaluate the amniotic fluid cathepsin-G concentrations in women with preterm prelabor rupture of membranes (PPROM) based on the presence of the microbial invasion of the amniotic cavity (MIAC) and/or intra-amniotic ...
Ivana Musilova, Tomas Bestvina, Lenka Pliskova, Soucek, Ondrej, Jan Maly, Ctirad Andrys, Pliskova, Lenka, Bo Jacobsson, Musilova, Ivana, Jacobsson, Bo,, Kacerovsky, Marian, Andrys, Ctirad, Bestvina, Tomas, Martin Stepan, Ondrej Soucek, Marian Kacerovsky, Marcela Drahosova, Drahosova, Marcela, Stepan, Martin, Maly, Jan   +19 more
core   +1 more source

Characterization of Lysosomal Hydrolases and Transporters and Their Age‐Dependent Variability: Relevance to Drug Metabolism and Transport of Small Molecule and Biologic Drugs

Clinical Pharmacology &Therapeutics, EarlyView.
Lysosomes play a key role in the accumulation, catabolism, and transport of endogenous and exogenous metabolites and proteins and are involved in drug metabolism and prodrug activation. However, the protein abundance and interindividual variability of lysosomal drug‐metabolizing enzymes and transporters (DMETs) remain underexplored.
Darshak Gadara, Dilip Kumar Singh, Sandhya Subash, Guihua Yue, Deepak Ahire, Chris Bohl, Maciej Czerwinski, Stephanie Helmstetter, Scott Heyward, Robert S. Jones, Cyrus Khojasteh, Ryota Kikuchi, Priyanka Kulkarni, Bin Ma, Bernard Murray, Chris Seib, Bill Smith, David M. Stresser, Mitchell E. Taub, Ting Wang, Bhagwat Prasad   +20 more
wiley   +1 more source

Deciphering the role of cathepsins in digestive system cancers: a Mendelian randomization study

Discover Oncology
Digestive system cancers (DSCs) present a global health challenge. This study aimed to investigate the causal relationships between cathepsins and DSCs using Mendelian Randomization (MR) analysis.
Beian Guo, Zhiyi Zhou, Wanzhe Liao, Yurong Zheng, Yinjie Liao, Ruiqi Zeng   +5 more
doaj   +1 more source