Results 181 to 190 of about 11,881,546 (284)

Application of an Activity-Based Probe to Determine Proteolytic Activity of Cell Surface Cathepsin G by Mass Cytometry Data Acquisition. [PDF]

ACS Omega, 2020
Gärtner F, Knippschild U, Burster T.
europepmc   +1 more source

Function of liver activation-regulated chemokine/CC chemokine ligand 20 is differently affected by cathepsin B and cathepsin D processing

, 2006
Chemokine processing by proteases is emerging as an important regulatory mechanism of leukocyte functions and possibly also of cancer progression. We screened a large panel of chemokines for degradation by cathepsins B and D, two proteases involved in ...
Hasan, Lara, Liebi, Mark, Overall, Christopher M, Tester, Angus, Lis, Maddalena, Wolf, Marlene, Mazzucchelli, Luca, Hunger, Robert E   +7 more
core  

PEG400 regulates Falcipain 2 activity through an allosteric mechanism

The FEBS Journal, EarlyView.
Falcipain‐2 can potentially be leveraged as a drug target due to its critical role as a haemoglobinase during the intra‐erythrocytic stage of Plasmodium falciparum. Here, we investigate the regulation of the proteolytic and haemoglobinase activity of falcipain‐2 in the presence of polyethylene glycol.
Bikram Nath, Subhoja Chakraborty, Sampa Biswas   +2 more
wiley   +1 more source

Physics-Based Protein Networks Might Recover Effectful Mutations─a Case Study on Cathepsin G. [PDF]

J Phys Chem B
Schuhmann F, Bordallo HN, Pezeshkian W.
europepmc   +1 more source

Targeted, receptor‐mediated delivery of a masked d‐amino acid cell‐penetrating peptide for cell‐specific phototoxicity

The FEBS Journal, EarlyView.
A targeted phototoxic peptide selectively accumulates in cells expressing chemokine‐like receptor 1 (CMKLR1). Phototoxicity of the native peptide is low, but cleavage by lysosomal protease cathepsin B releases a 6‐tetramethylrhodamine (TMR) labeled nona‐ᴅ‐arginine which mediates lysosomal rupture and cell death upon irradiation.
Moritz List, Eva‐Maria Jülke, Annette G. Beck‐Sickinger   +2 more
wiley   +1 more source

Substituted 4H-3,1-benzoxazine-4-one Derivatives as Inhibitors of Cathepsin G. [PDF]

Med Chem
Aliter KF, Al-Horani RA.
europepmc   +1 more source

Phenotypic characterization of Arabidopsis thaliana mutants that alleviate root growth defects in a vitamin B6 biosynthesis mutant

The FEBS Journal, EarlyView.
Vitamin B6 is a critical molecule for plant metabolism and development. Rsr4‐1, a loss‐of‐function mutant in a vitamin B6 biosynthesis gene, has a distinct short root phenotype. Here we describe five novel suppressor mutants with an rsr4‐1 background that have normalized root growth and distinct phenotypic and molecular characteristics, representing a ...
Marcelina Parra, Paige Henning, Clayton Bailes, Sanja Roje, Hanjo Hellmann   +4 more
wiley   +1 more source

Cathepsin G promotes arteriovenous fistula maturation by positively regulating the MMP2/MMP9 pathway. [PDF]

Ren Fail
Hu L, Zheng C, Kong Y, Luo Z, Huang F, Zhu Z, Li Q, Liang M.   +7 more
europepmc   +1 more source

High‐resolution spatial transcriptomic atlas of mouse soleus muscle: Unveiling single cell and subcellular heterogeneity in health and denervation

The FEBS Journal, EarlyView.
Seq‐Scope maps skeletal muscle transcriptomes at high spatial resolution while preserving histological context, revealing distinct responses of myofibers, neuromuscular junctions, and stromal cells to denervation. This spatial view uncovers fiber type‐specific and localized remodeling across intact muscle tissue.
Jer‐En Hsu, Lloyd Ruiz, Yongha Hwang, Steve D. Guzman, Chun‐Seok Cho, Weiqiu Cheng, Yichen Si, Peter Macpherson, Angelo Anacleto, Qingyang Zhao, Xiaoya Zhao, Mitchell Schrank, Goo Jun, Hyun Min Kang, Myungjin Kim, Susan V. Brooks, Jun Hee Lee   +16 more
wiley   +1 more source

Chronic Excessive Exercise Aggravates Apical Periodontitis in Mice

International Endodontic Journal, EarlyView.
ABSTRACT Aim To investigate the effects of overtraining on the development of apical periodontitis (AP) in mice. Methodology Sixty 6‐week‐old male C57BL/6 mice were allocated to six groups: sedentary without AP (SED); sedentary with AP (SED AP); aerobic training without AP (AERO); aerobic training with AP (AERO AP); overtraining without AP (OVER); and ...
Andréia Bosco Boaventura, Rosmeli Daysi Coasaca‐Rivera, Bárbara Roma Mendes, Sandra Lia do Amaral, Adelino Sanchez Ramos da Silva, Paulo Sergio Cerri, Gisele Faria   +6 more
wiley   +1 more source