Results 1 to 10 of about 108,127 (334)

Cathepsin L inhibition prevents murine autoimmune diabetes via suppression of CD8(+) T cell activity. [PDF]

PLoS ONE, 2010
BACKGROUND: Type 1 diabetes (T1D) is an autoimmune disease resulting from defects in central and peripheral tolerance and characterized by T cell-mediated destruction of islet β cells. To determine whether specific lysosomal proteases might influence the
Akiko Yamada, Naozumi Ishimaru, Rieko Arakaki, Nobuhiko Katunuma, Yoshio Hayashi   +4 more
doaj   +3 more sources

Eosinophils promote pulmonary matrix destruction and emphysema via Cathepsin L [PDF]

Signal Transduction and Targeted Therapy, 2023
Patients with chronic obstructive pulmonary disease (COPD) who exhibit elevated blood eosinophil levels often experience worsened lung function and more severe emphysema.
Xia Xu, Tao Yu, Lingling Dong, Rainer Glauben, Siyuan Wu, Ronghua Huang, Shiwei Qumu, Chenli Chang, Jing Guo, Lin Pan, Ting Yang, Xin Lin, Ke Huang, Zhihua Chen, Chen Wang   +14 more
doaj   +2 more sources

Cathepsin L Promotes Vascular Intimal Hyperplasia after Arterial Injury [PDF]

Molecular Medicine, 2017
The inflammatory pathways that drive the development of intimai hyperplasia (IH) following arterial injury are not fully understood. We hypothesized that the lysosomal cysteine protease cathepsin L activates processes leading to IH after arterial injury.
Jingjing Cai, Hua Zhong, Jinze Wu, Rui-Fang Chen, Huan Yang, Yousef Al-Abed, Ying Li, Xiaohui Li, Weihong Jiang, Marcelo F. Montenegro, Hong Yuan, Timothy R. Billiar, Alex F. Chen   +12 more
doaj   +2 more sources

Inactivation effect and kinetics of cathepsin L from white shrimp (Litopenaeus vannamei) by dense phase carbon dioxide [PDF]

Current Research in Food Science
The effects of dense phase carbon dioxide (DPCD) pressure and temperature on the activity of cathepsin L in white shrimp (Litopenaeus vannamei) were studied.
Ouyang Zheng, Xiaojie Cao, Yanqing Teng, Qinxiu Sun, Shucheng Liu   +4 more
doaj   +2 more sources

Lysosomal acidity and cathepsin L activate eosinophils via ARG1-mediated arginine metabolism in allergic airway inflammation [PDF]

Nature Communications
Eosinophils are the predominant immune cells implicated in the pathogenesis of asthma, highlighting the need for strategies to mitigate their effects. While previous studies have implicated the importance of lysosomes in eosinophil function, the precise ...
Yinling Han, Na Li, Yun Zhao, Zhangchu Jin, Baihui Lv, Dan Shen, Xinyi Chen, Qingyu Weng, Min Zhang, Kaijun Chen, Lingling Dong, Zhengyuan Liu, Jiafei Lou, Shenwei Gao, Yuejue Wang, Wen Hua, Fugui Yan, Songmin Ying, Yinfang Wu, Zhihua Chen, Wen Li   +20 more
doaj   +2 more sources

The Degradation of Intramuscular Connective Tissue In Vitro with Purified Cathepsin L from Bovine Pancreas [PDF]

Foods, 2023
To investigate the possible degradation of the intramuscular connective tissue (IMCT) with cathepsin L, isolated IMCTs were incubated with purified cathepsin L in vitro.
Yingbo Peng, Wanhong He, Shuang Teng, Muneer Ahmed Jamali   +3 more
doaj   +2 more sources

Fluorescence Polarization-Based High-Throughput Screening Assay for Inhibitors Targeting Cathepsin L. [PDF]

Bio Protoc
Guo K, You B, Zhou W, Li Y, Wang Z, Zhang J, Si S.   +6 more
europepmc   +2 more sources

Inhibition of cysteine protease cathepsin Lincreases the level and activity of lysosomal glucocerebrosidase [PDF]

JCI Insight
The glucocerebrosidase (GCase) encoded by the GBA1 gene hydrolyzes glucosylceramide (GluCer) to ceramide and glucose in lysosomes. Homozygous or compound heterozygous GBA1 mutations cause the lysosomal storage disease Gaucher disease (GD) due to severe ...
Myung Jong Kim, Soojin Kim, Thomas Reinheckel, Dimitri Krainc   +3 more
doaj   +2 more sources

Effect of Lysosomal Cathepsin L on Proteolysis of Beef Myofibrillar Proteins In Vivo and In Vitro

Foods, 2022
This study investigated the effects of cathepsin L on proteolysis of beef myofibrillar proteins in vivo and in vitro. Results indicated that cathepsin L affected the degradation of desmin and troponin-T during postmortem aging, and the extent of ...
Baowei Cui, Xiuyun Guo, Yawei Zhang, Xiangren Meng   +3 more
doaj   +1 more source

Characterization of Cysteine Cathepsin Expression in the Central Nervous System of Aged Wild-Type and Cathepsin-Deficient Mice

Applied Sciences, 2022
The association of cathepsin proteases in neurobiology is increasingly recognized. Our previous studies indicated that cathepsin-K-deficient (Ctsk−/−) mice have learning and memory impairments.
Denise M. T. Yu, Stephanie Dauth, Michael B. Margineanu, Valentina Snetkova, Maren Rehders, Silvia Jordans, Klaudia Brix   +6 more
doaj   +1 more source