Results 1 to 10 of about 16,299,204 (191)

A Review of Small Molecule Inhibitors and Functional Probes of Human Cathepsin L

Molecules, 2020
Human cathepsin L belongs to the cathepsin family of proteolytic enzymes with primarily an endopeptidase activity. Although its primary functions were originally thought to be only of a housekeeping enzyme that degraded intracellular and endocytosed ...
Dibyendu Dana, Sanjai K. Pathak
doaj   +2 more sources

Eosinophils promote pulmonary matrix destruction and emphysema via Cathepsin L [PDF]

Signal Transduction and Targeted Therapy, 2023
Patients with chronic obstructive pulmonary disease (COPD) who exhibit elevated blood eosinophil levels often experience worsened lung function and more severe emphysema.
Xia Xu, Tao Yu, Lingling Dong, Rainer Glauben, Siyuan Wu, Ronghua Huang, Shiwei Qumu, Chenli Chang, Jing Guo, Lin Pan, Ting Yang, Xin Lin, Ke Huang, Zhihua Chen, Chen Wang   +14 more
doaj   +2 more sources

Cathepsin L Promotes Vascular Intimal Hyperplasia after Arterial Injury

Molecular Medicine, 2017
The inflammatory pathways that drive the development of intimai hyperplasia (IH) following arterial injury are not fully understood. We hypothesized that the lysosomal cysteine protease cathepsin L activates processes leading to IH after arterial injury.
Jingjing Cai, Hua Zhong, Jinze Wu, Rui-Fang Chen, Huan Yang, Yousef Al-Abed, Ying Li, Xiaohui Li, Weihong Jiang, Marcelo F. Montenegro, Hong Yuan, Timothy R. Billiar, Alex F. Chen   +12 more
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Cathepsin L targeting in cancer treatment [PDF]

Pharmacology & Therapeutics, 2015
Proteolytic enzymes may serve as promising targets for novel therapeutic treatment strategies seeking to impede cancer progression and metastasis. One such enzyme is cathepsin L (CTSL), a lysosomal cysteine protease. CTSL upregulation, a common occurrence in a variety of human cancers, has been widely correlated with metastatic aggressiveness and poor ...
Dhivya R., Sudhan, Sudhan, Dhivya R., Siemann, Dietmar W.   +2 more
openaire   +4 more sources

Cathepsin L in unstable plaques

Archives of Medical Science – Atherosclerotic Diseases, 2020
Bridging the gap between the pathogenesis of atherosclerosis, carotid plaques, and contributing to patient care is envisioned by incorporating bench research into technological interventions. Stroke is a massive public health problem, and in stroke care, immediate assessment and treatment are essential to reduce the risk of death and disability [1, 2].
A. Bashir
openaire   +3 more sources

Inactivation effect and kinetics of cathepsin L from white shrimp (Litopenaeus vannamei) by dense phase carbon dioxide [PDF]

Current Research in Food Science
The effects of dense phase carbon dioxide (DPCD) pressure and temperature on the activity of cathepsin L in white shrimp (Litopenaeus vannamei) were studied.
Ouyang Zheng, Xiaojie Cao, Yanqing Teng, Qinxiu Sun, Shucheng Liu   +4 more
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Lysosomal acidity and cathepsin L activate eosinophils via ARG1-mediated arginine metabolism in allergic airway inflammation [PDF]

Nature Communications
Eosinophils are the predominant immune cells implicated in the pathogenesis of asthma, highlighting the need for strategies to mitigate their effects. While previous studies have implicated the importance of lysosomes in eosinophil function, the precise ...
Yinling Han, Na Li, Yun Zhao, Zhangchu Jin, Baihui Lv, Dan Shen, Xinyi Chen, Qingyu Weng, Min Zhang, Kaijun Chen, Lingling Dong, Zhengyuan Liu, Jiafei Lou, Shenwei Gao, Yuejue Wang, Wen Hua, Fugui Yan, Songmin Ying, Yinfang Wu, Zhihua Chen, Wen Li   +20 more
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The Degradation of Intramuscular Connective Tissue In Vitro with Purified Cathepsin L from Bovine Pancreas [PDF]

Foods, 2023
To investigate the possible degradation of the intramuscular connective tissue (IMCT) with cathepsin L, isolated IMCTs were incubated with purified cathepsin L in vitro.
Yingbo Peng, Wanhong He, Shuang Teng, Muneer Ahmed Jamali   +3 more
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Structural and Biochemical Analysis of the Dual Inhibition of MG-132 against SARS-CoV-2 Main Protease (Mpro/3CLpro) and Human Cathepsin-L

International Journal of Molecular Sciences, 2021
After almost two years from its first evidence, the COVID-19 pandemic continues to afflict people worldwide, highlighting the need for multiple antiviral strategies.
E. Costanzi, M. Kuzikov, F. Esposito, Simone Albani, N. Demitri, B. Giabbai, Marianna Camasta, E. Tramontano, Giulia Rossetti, A. Zaliani, P. Storici   +10 more
semanticscholar   +1 more source

MPI8 is Potent against SARS‐CoV‐2 by Inhibiting Dually and Selectively the SARS‐CoV‐2 Main Protease and the Host Cathepsin L

bioRxiv, 2021
A number of inhibitors have been developed for the SARS-CoV-2 main protease (MPro) as potential COVID-19 medications but little is known about their selectivity.
Xinyu R Ma, Yugendar R. Alugubelli, Yuying Ma, E. Vatansever, D. A. Scott, Yuchen Qiao, Ge-Shu Yu, Shiqing Xu, W. Liu   +8 more
semanticscholar   +1 more source