Results 21 to 30 of about 16,299,323 (310)
European Journal of Biochemistry, 1977 Cathepsin L was purified from rat liver lysosomes by cell fractionation, osmotic disruption of the lysosomes in the lysosomal mitochondrial pellet, gel filtration of the lysosomal extract and chromatography on CM‐Sephadex. Cathepsin L is a thiol proteinase and exists in several multiple forms visible on the disc electropherogram.
H, Kirschke +4 more
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PLoS ONE, 2015 Motivated by the recent implication of cysteine protease cathepsin L as a potential target for anti-cancer drug development, we used a conditional MycERTAM;Bcl-xL model of pancreatic neuroendocrine tumorigenesis (PNET) to assess the role of cathepsin L ...
Nicola R Brindle +7 more
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Extracellular cathepsin L stimulates axonal growth in neurons
BMC Research Notes, 2017 Objective Cathepsin L, a lysosomal endopeptidase expressed in most eukaryotic cells, is a member of the papain-like family of cysteine proteases. Although commonly recognized as a lysosomal protease, cathepsin L is also secreted and involved in the ...
Chihiro Tohda, Michihisa Tohda
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PLoS ONE, 2015 Cathepsin L [EC 3.4.22.15] is secreted via lysosomal exocytosis by several types of cancer cells, including prostate and breast cancer cells. We previously reported that human cultured fibrosarcoma (HT 1080) cells secrete cathepsin L into the medium ...
Yoko Hashimoto +2 more
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Cathepsin L increases invasion and migration of B16 melanoma
Cancer Cell International, 2007 Background Most cancers express elevated protease levels which contribute to certain aspects of tumor behavior such as growth, metastatic spread, and angiogenesis.
Cox James L, Yang Zhen
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Al-Mustansiriyah Journal of Science, 2020 Background and objectives: Toxoplasma gondii (T. gondii) is a ubiquitous apicomplexan parasite. As an obligate intracellular parasite, T. gondii must invade host cells to survive and replicate.
noor meran omer, Hadi M. A. Alsakee
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Elastinolytic activity of human cathepsin L [PDF]
Biochemical Journal, 1986 The hydrolysis of a tritiated elastin substrate by the human cysteine proteinases cathepsins B and L has been studied. Cathepsin L was found to be at least 100-fold more active on this substrate than cathepsin B. The specific activity of cathepsin L at pH 5.5 for hydrolysis of elastin was about the same as that of pig pancreatic elastase at its optimum
R W, Mason +3 more
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Immunohistochemical expression of cathepsin L in atopic dermatitis and lichen planus
Indian Journal of Dermatology, 2015 Background: Cathepsin L is a member of papain superfamily. It seems to promote T-cell survival, selection maturation in the thymus and enhance the antigen presentation.
Zeinab A El Ashmawy +3 more
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The expression of Cathepsin L in oral lichen planus
Journal of Oral Biology and Craniofacial Research, 2020 Background: Malignant transformation of oral lichen planus (OLP) was reported particularly in erosive type, however, it remains inconclusive. Cathepsin L was shown to promote tumor growth and invasion in many cancers. Therefore, cathepsin L expression in
Athip Kitkhajornkiat +4 more
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Molecules, 2021 We investigated the effect of endogenous cathepsin L on surimi gel produced from olive flounder (Paralichthys olivaceus). The amino acid sequences of six proteins predicted or identified as cathepsin L were obtained from the olive flounder genome ...
Chang Woo Kwon, Pahn-Shick Chang
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