Results 31 to 40 of about 623 (108)
New Functional Aspects of Cathepsin D and Cathepsin E
Molecules and Cells, 2000 Cathepsin D (CD) and cathepsin E are representative lysosomal and nonlysosomal aspartic proteinases, respectively, and play an important role in the degradation of proteins, the generation of bioactive proteins, antigen processing, etc. Recenty, several lines of evidence have suggested the involvement of these two enzymes in the execution of neuronal ...
Kenji Yamamoto +5 more
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Expression of Cathepsins B, D and G in Infantile Hemangioma
Frontiers in Surgery, 2015 Aims: The role of the renin-angiotensin system (RAS) in the biology of infantile hemangioma (IH) represents an emerging paradigm, particularly the involvement of renin, angiotensin converting enzyme and angiotensin II.
Tinte eItinteang +6 more
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Cathepsins as Transcriptional Activators? [PDF]
Developmental Cell, 2004 One action of proteases is limited cleavage of latent transcription factors, releasing active factors to initiate nuclear signaling. Goulet et al., in a recent Molecular Cell paper, provide evidence that a lysosomal protease, cathepsin L, exists in a previously unsuspected isoform capable of trafficking to the nucleus and activating the CDP/Cux ...
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PLoS ONE, 2015 Cathepsins are proteases involved in the ability of parasites to overcome and/or modulate host defenses so as to complete their own lifecycle. However, the mechanisms underlying this ability of cathepsins are still poorly understood.
Waleska Maldonado-Aguayo +3 more
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The role of lysosomal cysteine proteases in tumor progression
Бюллетень сибирской медицины, 2009 Cysteine cathepsins have been known for a long time to play an important role in cancer progression. Here we summarize their impact to the hallmark processes of malignant growth such as cell proliferation, apoptosis, angiogenesis, invasion and metastasis.
M. S. Korovin +2 more
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Cathepsins in Bacteria-Macrophage Interaction: Defenders or Victims of Circumstance?
Frontiers in Cellular and Infection Microbiology, 2020 Macrophages are the first encounters of invading bacteria and are responsible for engulfing and digesting pathogens through phagocytosis leading to initiation of the innate inflammatory response.
Lidia Szulc-Dąbrowska +4 more
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Role of cathepsin A and cathepsin C in the regulation of glycosidase activity
Folia Histochemica et Cytobiologica, 2012 Increased tissue activity of cathepsin A and cathepsin C can be observed in many pathological conditions. It is associated with an enhanced degradation of glycosaminoglycans, proteoglycans, and glycoproteins, and results in their decreased tissue content. Cathepsin C releases the glycosidases from complexes formed with cathepsin A, and reinstates their
Marek Gacko +4 more
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EMBO Molecular Medicine, 2021 In the course of our studies aiming to discover vascular bed‐specific endothelial cell (EC) mitogens, we identified leukemia inhibitory factor (LIF) as a mitogen for bovine choroidal EC (BCE), although LIF has been mainly characterized as an EC growth ...
Pin Li +11 more
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Cathepsins in digestive cancers
Oncotarget, 2017 Cathepsins are lysosomal peptidases belonging to the papain family, and based on their catalytic sites, these enzymes can be divided into serine, cysteine and aspartic proteases. The studies conducted to date have identified, 15 types of cathepsins that are widely distributed in intracellular and extracellular spaces.
Siyuan Chen +3 more
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The Specificity of Cathepsin D
Journal of Biological Chemistry, 1973 Abstract Bovine spleen cathepsin D has been partially purified for studies of its specificity. Isoelectric focusing of the purest preparation obtained indicated the presence of three molecular forms having approximately the same specific activity, but differing in their isoelectric points.
John B. Ferguson +3 more
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