Results 51 to 60 of about 623 (108)
Parkinson disease is a TH17 dominant autoimmune disorder against accumulated alpha-synuclein [PDF]
arXiv, 2013 Parkinson disease is a very common neurodegenerative disorder. Patients usually undergo destruction of substantia nigra to develop typical symptoms such as resting tremor, hypokinesia, and rigidity. However, the exact mechanism of Parkinson disease is still unknown, so it is called idiopathic Parkinsonism.
arxiv
Folia Histochemica et Cytobiologica, 2008 A literature survey was performed of human cathepsin D gene, cathepsin D biosynthesis, posttranslatory modifications, transport within the cell, substrate specificity and catalytic effect. Methods used to determine the activity and level of this proteinase as well as its role in the biochemistry and pathobiochemistry of cells, tissues and organs were ...
Alina Minarowska +3 more
openaire +5 more sources
Molecular Neurodegeneration, 2012 Background Dominantly inherited missense mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson's disease, but its normal physiological function remains unclear.
Tong Youren +8 more
doaj +1 more source
The Role of Cathepsins in Memory Functions and the Pathophysiology of Psychiatric Disorders
Frontiers in Psychiatry, 2020 Cathepsins are proteases with functions in cellular homeostasis, lysosomal degradation and autophagy. Their role in the development of neurodegenerative diseases has been extensively studied.
Christine Niemeyer +7 more
doaj +1 more source
Mathematical deep learning for pose and binding affinity prediction and ranking in D3R Grand Challenges [PDF]
arXiv, 2018 Advanced mathematics, such as multiscale weighted colored graph and element specific persistent homology, and machine learning including deep neural networks were integrated to construct mathematical deep learning models for pose and binding affinity prediction and ranking in the last two D3R grand challenges in computer-aided drug design and discovery.
arxiv
MathDL: Mathematical deep learning for D3R Grand Challenge 4 [PDF]
arXiv, 2019 We present the performances of our mathematical deep learning (MathDL) models for D3R Grand Challenge 4 (GC4). This challenge involves pose prediction, affinity ranking, and free energy estimation for beta secretase 1 (BACE) as well as affinity ranking and free energy estimation for Cathepsin S (CatS).
arxiv
Acute Respiratory Distress Syndrome is a TH17-like and Treg immune disease [PDF]
arXiv, 2013 Acute Respiratory Distress Syndrome (ARDS) is a very severe syndrome leading to respiratory failure and subsequent mortality. Sepsis is one of the leading causes of ARDS. Thus, extracellular bacteria play an important role in the pathophysiology of ARDS. Overactivated neutrophils are the major effector cells in ARDS.
arxiv
Generative network complex (GNC) for drug discovery [PDF]
arXiv, 2019 It remains a challenging task to generate a vast variety of novel compounds with desirable pharmacological properties. In this work, a generative network complex (GNC) is proposed as a new platform for designing novel compounds, predicting their physical and chemical properties, and selecting potential drug candidates that fulfill various druggable ...
arxiv
Cathepsins and neurological diseases: a Mendelian randomization study
Frontiers in NeuroscienceBackgroundThe causal relationship between cathepsins and neurological diseases remains uncertain. To address this, we utilized a two-sample Mendelian randomization (MR) approach to assess the potential causal effect of cathepsins on the development of ...
Haitao Sun +5 more
doaj +1 more source
"Collagenase" Activity of Cathepsins.
Experimental Biology and Medicine, 1954 SummaryPapain and ficin digest collagen in the pH 2.0-4.5 range at low salt concentration. Evidence is presented that collagen undergoes a reversible alteration at low pH which renders it susceptible to digestion by a number of proteolytic enzymes active at acid pH's.
Sol Sherry +2 more
openaire +3 more sources