Results 71 to 80 of about 84,247 (372)

Cathepsins in oral diseases

Journal of Dr. NTR University of Health Sciences, 2019
Cathepsins are a class of globular lysosomal proteases known to be responsible for protein degradation. In addition to proteolysis they have many biological roles such as apoptosis wound healing angiogenesis, proenzymatic activation, bone remodelling and
K Ajay Benarji, K Roja Lakshmi, Hasini Nelakurthi, Pothuraju Haritha, Rudraraju Amrutha   +4 more
doaj   +1 more source

Protease inhibitors targeting coronavirus and filovirus entry. [PDF]

, 2015
In order to gain entry into cells, diverse viruses, including Ebola virus, SARS-coronavirus and the emerging MERS-coronavirus, depend on activation of their envelope glycoproteins by host cell proteases.
Agudelo, Juliet, Barnard, Dale, Carrion, Ricardo, Lu, Kai, McKerrow, James H, Nunneley, Jerritt W, Pöhlmann, Stefan, Renslo, Adam R, Simmons, Graham, Vedantham, Punitha, Zhou, Yanchen   +10 more
core   +1 more source

Role of Cathepsins in Mycobacterium tuberculosis Survival in Human Macrophages

Scientific Reports, 2016
Cathepsins are proteolytic enzymes that function in the endocytic pathway, especially in lysosomes, where they contribute directly to pathogen killing or indirectly, by their involvement in the antigen presentation pathways.
David Pires, J. Marques, J. Pombo, N. Carmo, Paulo J G Bettencourt, O. Neyrolles, G. Lugo-Villarino, E. Anes   +7 more
semanticscholar   +1 more source

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

Association between cathepsins and benign prostate diseases: a bidirectional two-sample Mendelian randomization study

Frontiers in Endocrinology
ObjectivesThe relationship between cathepsins and prostate cancer (PCa) has been reported. However, there is a lack of research on cathepsins and benign prostate diseases (BPDs).
Hongliang Cao, Bin Liu, Kejian Gong, Hao Wu, Yishu Wang, Haiyang Zhang, Chengdong Shi, Pengyu Wang, Hao Du, Honglan Zhou, Song Wang   +10 more
doaj   +1 more source

LIF, a mitogen for choroidal endothelial cells, protects the choriocapillaris: implications for prevention of geographic atrophy

EMBO Molecular Medicine, 2021
In the course of our studies aiming to discover vascular bed‐specific endothelial cell (EC) mitogens, we identified leukemia inhibitory factor (LIF) as a mitogen for bovine choroidal EC (BCE), although LIF has been mainly characterized as an EC growth ...
Pin Li, Qin Li, Nilima Biswas, Hong Xin, Tanja Diemer, Lixian Liu, Lorena Perez Gutierrez, Giovanni Paternostro, Carlo Piermarocchi, Sergii Domanskyi, Ruikang K Wang, Napoleone Ferrara   +11 more
doaj   +1 more source

Fabrication, Properties, and Applications of Scaffolds for Bone Tissue Regeneration

Advanced Materials Technologies, EarlyView.
This review explores cutting‐edge biomaterials and fabrication techniques for scaffolds in bone tissue regeneration. It conducts a critical comparison of various strategies, meticulously analyzes the key contradictions in the field, and outlines an integrated development path spanning from biomaterial selection to clinical application, while ...
Shangsi Chen, Min Wang
wiley   +1 more source

CCDC41 Drives Oocyte Meiotic Progression by Promoting Rab11a/Rab7‐Positive Vesicle Fusion with Target Membranes

Advanced Science, EarlyView.
CCDC41 is essential for meiotic maturation in mouse oocytes through regulating Rab7‐positive endosomes fusion with lysosomes and Rab11a‐positive vesicle fusion with the plasma membrane. Abstract Coiled‐coil domain‐containing protein 41 (CCDC41), a core component of centriolar distal appendages involved in centriole assembly and ciliary vesicle docking,
Ying Tian, Jiatong Li, Jingyi Kang, Xiangning Xu, Bicheng Wang, Shuo Lou, Jingyu Li, Yuying Yang, Yanbing Zhang, Yangzi Zheng, Jing Weng, Yuanjing Liang, Wei Ma   +12 more
wiley   +1 more source

Structure-activity relationships of hypervalent organochalcogenanes as inhibitors of cysteine cathepsins V and S [PDF]

, 2011
A new series of organotelluranes were synthesized and investigated, and the structure-activity relationships in cysteine proteases inhibition were determinated.
Alves, Marcio Fernando, Andrade, Leandro H., Broemme, Dieter, Cunha, Rodrigo Luiz Oliveira Rodrigues, Juliano, Luiz, Piovan, Leandro   +5 more
core   +1 more source

Cathepsin B inhibition interferes with metastatic potential of human melanoma: an in vitro and in vivo study

Molecular Cancer, 2010
Background Cathepsins represent a group of proteases involved in determining the metastatic potential of cancer cells. Among these are cysteinyl- (e.g. cathepsin B and cathepsin L) and aspartyl-proteases (e.g.
Matarrese Paola, Ascione Barbara, Ciarlo Laura, Vona Rosa, Leonetti Carlo, Scarsella Marco, Mileo Anna M, Catricalà Caterina, Paggi Marco G, Malorni Walter   +9 more
doaj   +1 more source