Results 121 to 130 of about 644 (163)
The Effects of Khat Chewing among Djiboutians: Dental Chemical Studies, Gingival Histopathological Analyses and Bioinformatics Approaches. [PDF]
Bioengineering (Basel)Mohamed Abdoul-Latif F +6 more
europepmc +1 more source
Structure-Activity Relationship of Synthetic Cathinones: An Updated Review. [PDF]
ACS Pharmacol Transl SciNadal-Gratacós N +6 more
europepmc +1 more source
Drug Testing and Analysis, 2009 Until the end of 2003 a urinary concentration of pseudoephedrine exceeding 25 mu g/mL was regarded as a doping violation by the World Anti-Doping Agency.
Oscar J. Pozo, Guy Baele, K Deventer
exaly +4 more sources
Therapeutic Drug Monitoring, 2009 This article describes a method for the detection and quantitation of cathine, pseudoephedrine, ephedrine, and methylephedrine in urine, using their deuterated analogues as internal standards and derivatization to form the corresponding trimethylsilyl ...
Francesco Botrè +2 more
exaly +5 more sources
International Journal of Toxicology, 2022 Cathine is the stable form of cathinone, the major active compound found in khat (Catha edulis Forsk) plant. Khat was found to inhibit major phase I drug metabolizing cytochrome P450 (CYP) enzyme activities in vitro and in vivo.
Mustafa Ahmed Alshagga +2 more
exaly +1 more source
Cathine and cathinone disposition kinetics and neurotransmitter profile in several organs of rats exposed to a single dose of Catha edulis (Vahl) Forssk. ex Endl. extract [PDF]
Drug Metabolism and Personalized Therapy, 2023 Catha edulis (Vahl) Forssk. ex Endl. (Khat) is a stimulant plant that contains cathine and cathinone, which its abuses induce euphoria, alertness, and motor activity. Since the toxicokinetics of these substances remain unclear, this study was carried out
Ibraheem M Attafi
exaly +2 more sources
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Dopaminergic nature of acute cathine tolerance
Pharmacology Biochemistry and Behavior, 1990Cathine is a psychoactive constituent in the leaves of the Khat shrub which are habitually ingested for their stimulatory effects in many parts of the world. Rats were trained to discriminate the stimulus effect of intraperitoneally administered 4.8 mg/kg d-cathine and, once trained, administration of another Khat constituent, cathinone, was shown to ...
Martin D Schechter
exaly +3 more sources
Pharmacokinetics of cathinone, cathine and norephedrine after the chewing of khat leaves [PDF]
British Journal of Clinical Pharmacology, 2003 Aim The stimulating herbal drug khat is habitually used in East Africa and the Arabian peninsula but is also imported into other countries. The aim was to study the pharmacokinetics of its alkaloids cathinone, cathine and norephedrine.Methods Four volunteers chewed khat leaves in an amount equivalent to one‐quarter of that used in a typical khat ...
Stefan W Toennes, Sebastian Harder
exaly +3 more sources
Discriminative stimulus properties of (+)cathine, an alkaloid of the khat plant
Pharmacology Biochemistry and Behavior, 1990The effects of the psychostimulant (+)cathine (norpseudoephedrine) were examined in a two-choice, food-motivated, drug-discrimination paradigm. Rats were able to discriminate cathine from vehicle and this effect was dose- and time-dependent. Prior administration of cathine resulted in a diminished response (tolerance) to subsequent cathine and this ...
Martin D Schechter, Elizabeth A Pehek
exaly +3 more sources
Pharmacokinetics and distribution of cathine and cathinone in rats
The FASEB Journal, 2022Khat is a stimulant plant that contains stimulant chemicals such as cathine and cathinone, which abuses to induce euphoria, alertness, and motor activity. This study was carried out to determine the pharmacokinetic and distributions of cathine and cathinone following a single dosage of khat extract in rats.
Ibraheem M. Attafi +10 more
openaire +1 more source