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Preparation and evaluation of molecularly imprinted polymer liquid chromatography column for the separation of Cathine enantiomers [PDF]

open access: yesSaudi Pharmaceutical Journal, 2012
In this study molecular imprinting technology was employed to prepare a specific affinity sorbent for the resolution of Cathine, a chiral drug product. The molecularly imprinted polymer (MIP) was prepared by non-covalent molecular imprinting with either (
Gokulakrishnan, Kannan   +5 more
exaly   +2 more sources
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Design of molecularly imprinted resin material with sulfonic acid functionalization for enantioseparation of (±)-cathine

Chirality, 2023
AbstractIn the current work, an enantioselective imprinting technique was used to develop a very selective adsorbent for the (+)‐cathine ((+)‐Cat) enantiomer. The phenolic sulfonamide produced from 2,4‐dihydroxybenzenesulfonic acid (HBS) and (+)‐Cat ((+)‐Cat‐HBS) was initially synthesized by triphenylphosphene activation and subsequently involved in ...
Aliyah Alhawiti
exaly   +3 more sources

Determination of cathinone and cathine in Khat plant material by LC–MS/MS: Fresh vs. dried leaves

Forensic Science International, 2021
The consumption of Khat leaves represents an ancient kind of drug abuse mainly observed in Eastern Africa and the Arab Peninsula among adult men. For this purpose, the leaves are directly collected from the shrub "Catha edulis" prior to extensive chewing process.
Martin G Schmid, Manfred Kollroser
exaly   +3 more sources

Rats become acutely tolerant to cathine after amphetamine or cathinone administration

Psychopharmacology, 1990
The drug discrimination paradigm was used to evaluate in rats the ability of the discriminate response to either 0.8 mg/kg d-amphetamine or 0.8 mg/kg l-cathinone to generalize to 2.4-6.0 mg/kg of the active cathinone metabolite d-norpseudoephedrine, also known as cathine.
Martin D Schechter, M D Schechter
exaly   +3 more sources

A GC-MS Method for Detection and Quantification of Cathine, Cathinone, Methcathinone and Ephedrine in Oral Fluid. [PDF]

open access: yesJournal of Chromatographic Science, 2016
The stimulating herbal drug khat (cathine, cathinone) and its analog methcathinone are common substances of abuse in most countries. A GC-MS method was developed and validated for the detection and quantification of cathine, cathinone, methcathinone and ephedrine in oral fluid specimens.
Khaled M. Mohamed
exaly   +3 more sources

Biochemical effects of Catha edulis, cathine and cathinone on adrenocortical functions

Journal of Ethnopharmacology, 1993
Catha edulis is a plant that grows in certain areas of East Africa and the Arab Peninsula. The stimulating properties of fresh material were described more than seven centuries ago and today the habit of inducing a state of euphoria and subjective well-being by chewing Catha edulis prevails among the inhabitants of these regions. Oral administration of
M B, Ahmed, A B, el-Qirbi
openaire   +2 more sources

The stimulant cathine from Khat causes tachycardia indirectly in the rat

Basic and Clinical Pharmacology and Toxicology
AbstractLeaves of the Khat plant are widely consumed in the Horn of Africa, Yemen and the Jazan region of Saudi Arabia. I have investigated the mode of cardiovascular and autonomic actions of the stimulant cathine from Khat in terms of direct or indirect adrenergic actions in anaesthetised male and female rats, and in isolated tissues.
Hadeel A. Alsufyani
exaly   +3 more sources

Determination of cathinone, cathine and norephedrine in hair of Yemenite khat chewers

Forensic Science International, 2003
A sensitive and reproducible method for the quantitative determination of cathinone (CTN), norpseudoephedrine (NPE, cathine) and norephedrine (NE) from hair was developed. The compounds were extracted for 4 hours with phosphate buffer pH 2.0, followed by a standard solid phase extraction procedure on a mixed phase column, derivatization with ...
Frank, Sporkert   +4 more
openaire   +2 more sources

Kathsträucher, Cathin, Cathinon, Suchtgift, psychotroper Stoff

Journal für Strafrecht, 2020
Das in den Zweigspitzen und jungen Blattern von Kathstrauchern enthaltene Cathin ist ein psychotroper Stoff iS des SMG, das darin enthaltene Cathinon ist ein Suchtgift iS des SMG. Die Einfuhr von Kathstrauchern verwirklicht daher die Vergehen gem § 30 Abs 1 5. Fall (bzw § 31a Abs 1 2. Fall) SMG und § 27 Abs 1 Z 1 5. Fall (bzw § 28a Abs 1 1. Fall) SMG.
openaire   +1 more source

Neue Informationen zu Cathin (Norpseudoephedrin)

Adipositas - Ursachen, Folgeerkrankungen, Therapie, 2018
ZusammenfassungCathin ist in Catha edulis (Khatstrauch oder Abessinischer Tee) Blättern enthalten und wirkt indirekt sympathomimetisch im zentralen Nervensystem genauso wie in der Peripherie. In der ersten kontrollierten Dosisfindungsstudie an 241 adipösen Patienten über 24 Wochen ergab sich eine signifikant größere Gewichtsreduktion mit den drei ...
openaire   +1 more source

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