Results 151 to 160 of about 1,249 (192)
Pharmacokinetics of cathinone, cathine and norephedrine after the chewing of khat leaves [PDF]
British Journal of Clinical Pharmacology, 2003 Aim The stimulating herbal drug khat is habitually used in East Africa and the Arabian peninsula but is also imported into other countries. The aim was to study the pharmacokinetics of its alkaloids cathinone, cathine and norephedrine.Methods Four volunteers chewed khat leaves in an amount equivalent to one‐quarter of that used in a typical khat ...
Stefan W Toennes
exaly +5 more sources
A GC–MS Method for Detection and Quantification of Cathine, Cathinone, Methcathinone and Ephedrine in Oral Fluid [PDF]
Journal of Chromatographic Science, 2016 The stimulating herbal drug khat (cathine, cathinone) and its analog methcathinone are common substances of abuse in most countries. A GC-MS method was developed and validated for the detection and quantification of cathine, cathinone, methcathinone and ephedrine in oral fluid specimens.
Khaled M Mohamed
exaly +4 more sources
The stimulant cathine from Khat causes tachycardia indirectly in the rat [PDF]
Basic and Clinical Pharmacology and ToxicologyAbstractLeaves of the Khat plant are widely consumed in the Horn of Africa, Yemen and the Jazan region of Saudi Arabia. I have investigated the mode of cardiovascular and autonomic actions of the stimulant cathine from Khat in terms of direct or indirect adrenergic actions in anaesthetised male and female rats, and in isolated tissues.
Hadeel A Alsufyani
exaly +4 more sources
Discriminative stimulus properties of (+)cathine, an alkaloid of the khat plant
Pharmacology Biochemistry and Behavior, 1990 The effects of the psychostimulant (+)cathine (norpseudoephedrine) were examined in a two-choice, food-motivated, drug-discrimination paradigm. Rats were able to discriminate cathine from vehicle and this effect was dose- and time-dependent. Prior administration of cathine resulted in a diminished response (tolerance) to subsequent cathine and this ...
E A, Pehek, M D, Schechter
exaly +4 more sources
Chirality, 2023 AbstractIn the current work, an enantioselective imprinting technique was used to develop a very selective adsorbent for the (+)‐cathine ((+)‐Cat) enantiomer. The phenolic sulfonamide produced from 2,4‐dihydroxybenzenesulfonic acid (HBS) and (+)‐Cat ((+)‐Cat‐HBS) was initially synthesized by triphenylphosphene activation and subsequently involved in ...
Aliyah S Alhawiti
exaly +4 more sources
Pharmacokinetics and distribution of cathine and cathinone in rats
The FASEB Journal, 2022 Khat is a stimulant plant that contains stimulant chemicals such as cathine and cathinone, which abuses to induce euphoria, alertness, and motor activity. This study was carried out to determine the pharmacokinetic and distributions of cathine and cathinone following a single dosage of khat extract in rats.
Ibraheem M. Attafi +10 more
openaire +2 more sources
Dopaminergic nature of acute cathine tolerance
Pharmacology Biochemistry and Behavior, 1990 Cathine is a psychoactive constituent in the leaves of the Khat shrub which are habitually ingested for their stimulatory effects in many parts of the world. Rats were trained to discriminate the stimulus effect of intraperitoneally administered 4.8 mg/kg d-cathine and, once trained, administration of another Khat constituent, cathinone, was shown to ...
Martin D. Schechter
exaly +4 more sources
Biochemical effects of Catha edulis, cathine and cathinone on adrenocortical functions
Journal of Ethnopharmacology, 1993 Catha edulis is a plant that grows in certain areas of East Africa and the Arab Peninsula. The stimulating properties of fresh material were described more than seven centuries ago and today the habit of inducing a state of euphoria and subjective well-being by chewing Catha edulis prevails among the inhabitants of these regions. Oral administration of
Mohammad Boshir Ahmed
exaly +4 more sources
Pharmacology Biochemistry and Behavior, 1984 Rats trained to discriminate between the stimulus properties of 0.6 mg/kg of racemic cathinone and its vehicle, in a two-lever operant task for food reinforcement, were administered doses of S(-)-cathinone, R(+)-cathinone, (+)-cathine and several structurally-related derivatives, in order to study structure-activity relationships.
Richard A Glennon
exaly +4 more sources
Determination of cathinone and cathine in Khat plant material by LC–MS/MS: Fresh vs. dried leaves
Forensic Science International, 2021 The consumption of Khat leaves represents an ancient kind of drug abuse mainly observed in Eastern Africa and the Arab Peninsula among adult men. For this purpose, the leaves are directly collected from the shrub "Catha edulis" prior to extensive chewing process.
Martin G Schmid
exaly +4 more sources