Results 11 to 20 of about 1,249 (192)
Progress in Microbes and Molecular Biology, 2023 The significant influence of khat, cathinone, and cathine on appetite suppression, reproduction impairment, and inhibitory effects on CYPs enzyme activity is widely recognised, but much remains unknown about its mode of action.
Sharoen Yu Ming Lim +5 more
doaj +4 more sources
Efficacy and Safety of Cathine (Nor-Pseudoephedrine) in the Treatment of Obesity: A Randomized Dose-Finding Study [PDF]
Obesity Facts, 2017 Objective: To investigate the efficacy and safety of increasing doses of cathine (nor-pseudoephedrine) as a weight-lowering agent in patients with obesity.
Hans Hauner +5 more
doaj +4 more sources
Postmortem Distribution of Cathinone and Cathine in Human Biological Specimens in a Case of Death Associated with Khat Chewing [PDF]
Arab Journal of Forensic Sciences & Forensic Medicine, 2018 Chewing khat leaves has been associated with several adverse health effects, and there are very few case reports of cardiotoxicity, stroke and death resulting from this.
Ibraheem M. Attafi +5 more
doaj +3 more sources
Al-Azhar Assiut Medical Journal, 2019 Background Molecular docking is commonly used in the study of small-molecule–protein interaction. Amphetamine (AMPH), cathine (CATHI), and cathinone (CATHO) bind in silico with monoamine oxidase B (MAO B) with relatively low affinity.
Jerah A Ahmed
doaj +3 more sources
The Appetite Suppressant D-norpseudoephedrine (Cathine) Acts via D1/D2-Like Dopamine Receptors in the Nucleus Accumbens Shell [PDF]
Frontiers in Neuroscience, 2020 D-norpseudoephedrine (NPE), also known as cathine, is found naturally in the shrub Catha edulis “Khat.” NPE has been widely used as an appetite suppressant for the treatment of obesity. Although it is known that NPE acts on α1-adrenergic receptors, there
B. Kalyanasundar +4 more
doaj +4 more sources
Cathine and norephedrine, both phenylpropanolamines, accelerate capacitation and then inhibit spontaneous acrosome loss [PDF]
Human Reproduction, 2005 Cathinone, released when Catha edulis leaves (khat) are chewed, has euphoric, stimulatory properties. It is metabolized to the phenylpropanolamines (PPAs) cathine and norephedrine. This study investigated whether PPAs affect mammalian sperm function, using primarily mouse, but also human, spermatozoa.Uncapacitated sperm suspensions were treated with ...
Adeoya-Osiguwa, S A, Fraser, L R
openaire +4 more sources
Protein-Ligand Identification and In Vitro Inhibitory Effects of Cathine on 11 Major Human Drug Metabolizing Cytochrome P450s. [PDF]
Int J Toxicol, 2022 Cathine is the stable form of cathinone, the major active compound found in khat ( Catha edulis Forsk) plant. Khat was found to inhibit major phase I drug metabolizing cytochrome P450 (CYP) enzyme activities in vitro and in vivo. With the upsurge of khat consumption and the potential use of cathine to combat obesity, efforts should be channelled into ...
Lim SYM +5 more
europepmc +5 more sources
Cathine, an amphetamine-related compound, acts on mammalian spermatozoa via beta1- and 2A-adrenergic receptors in a capacitation state-dependent manner [PDF]
Human Reproduction, 2006 Mammalian spermatozoa have been shown to have beta(1,2,3)- and alpha(2A)-adrenergic receptors, the former functioning only in uncapacitated spermatozoa and the latter only in capacitated cells. Cathine, an amphetamine-related metabolite of a compound found in Catha edulis leaves, accelerates capacitation and inhibits spontaneous acrosome loss by ...
S A, Adeoya-Osiguwa, Lynn R, Fraser
openaire +3 more sources
Identification of Cathine in Unknown White Crystalline Substance in Sri Lanka
International Journal of Forensic SciencesThe drug abuse in Sri Lanka is continuously grown fast and variety of new narcotic drugs comes to the market day by day. Cathine {(1S,2S)-2-amino-1-phenylpropan-1-ol} is a monoamine alkaloid found naturally in the shrub Catha edulis (Khat). It is a psychoactive drug of the phenethylamine and amphetamine chemical classes which act as a stimulant.
Chandani Priyadarshika Kumarapeli
openaire +2 more sources
, 2017 Objective: To investigate the efficacy and safety of increasing doses of cathine (nor-pseudoephedrine) as a weight-lowering agent in patients with obesity. Methods:Overweight and obese patients (n = 241, mean BMI 34.6 ± 3.4 kg/m²) were randomly allocated to one of three doses of cathine (16 mg, 32 mg, 53.3 mg) or placebo in addition to a multimodal ...
H., Hauner +5 more
+4 more sources