Expressed sequence tag analysis of khat (Catha edulis) provides a putative molecular biochemical basis for the biosynthesis of phenylpropylamino alkaloids [PDF]
Genetics and Molecular Biology, 2011 Khat (Catha edulis Forsk.) is a flowering perennial shrub cultivated for its neurostimulant properties resulting mainly from the occurrence of (S)-cathinone in young leaves.
Jillian M. Hagel +6 more
doaj +2 more sources
Khat chewing and associated factors among public secondary school students in Harar town, Eastern Ethiopia: a multicenter cross-sectional study [PDF]
Frontiers in Psychiatry, 2023 BackgroundKhat is a huge, evergreen tree that grows at high altitudes throughout the Arabian Peninsula and in the region stretching from eastern to southern Africa.
Kabtamu Nigussie +7 more
doaj +2 more sources
Al-Azhar Assiut Medical Journal, 2019 Background Molecular docking is commonly used in the study of small-molecule–protein interaction. Amphetamine (AMPH), cathine (CATHI), and cathinone (CATHO) bind in silico with monoamine oxidase B (MAO B) with relatively low affinity.
Jerah A Ahmed
doaj +2 more sources
Forensic Science International, 2012 In the last years, all the vegetable material supposed to belong to the Catha Edulis species, seized at the Malpensa and Orio al Serio airports, were analysed in our laboratory on behalf of the Tribunals of Busto Arsizio and Bergamo, respectively.
G. Roda +11 more
core +5 more sources
Evaluation of the effect of various drying techniques on the composition of the psychoactive phenylpropylamino alkaloids of khat (Catha edulis Forsk) chewing leaves [PDF]
Bulletin of the Chemical Society of Ethiopia, 2013 The study demonstrated that by freezing or drying under different conditions, cathinone could be detected in the khat (Catha edulis Forsk) samples that have been harvested for more than four months.
S. Chigome +5 more
doaj +2 more sources
The Appetite Suppressant D-norpseudoephedrine (Cathine) Acts via D1/D2-Like Dopamine Receptors in the Nucleus Accumbens Shell [PDF]
Frontiers in Neuroscience, 2020 D-norpseudoephedrine (NPE), also known as cathine, is found naturally in the shrub Catha edulis “Khat.” NPE has been widely used as an appetite suppressant for the treatment of obesity. Although it is known that NPE acts on α1-adrenergic receptors, there
B. Kalyanasundar +4 more
doaj +3 more sources
In vitro and in vivo metabolism profiles of cathinone and pseudoephedrine: Discrimination between khat and pseudoephedrine uses. [PDF]
J Forensic SciAbstract In the present study, the metabolism of khat (Catha edulis) and pseudoephedrine was compared with the aim of identifying objective criteria that could be used to discriminate between them for forensic and doping‐control purposes. An in vitro study using human liver microsomes and an in vivo study using rat urine were performed under harmonized
Park JS +6 more
europepmc +2 more sources
Analytical Challenges in Detecting New Psychoactive Substances in Anti-Doping: A Proof-of-Concept Involving Pentedrone Metabolite. [PDF]
Drug Test AnalThe paper describes an investigation related to the pentedrone norephedrine metabolite. The athlete's sample was analyzed using ultra‐performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS). According to the literature, this metabolite may originate from pentedrone, α‐pyrrolidinopentiophenone (PVP), or N‐ethylpentedrone (NEP).
Kwiatkowska D +8 more
europepmc +2 more sources
, 2011 The main effect of khat assumption is a psychoactive stimulation similar to that produced by amphetamines. The substances responsible for the central nervous system stimulatory effect are alkaloids with an amphetamine-like structure: cathinone, cathine ...
G. Roda +6 more
core +4 more sources
USING HIGH PERFORMANCE THIN LAYER CHROMATOGRAPHYTODETECT THE PRESENCE OF CATHINONE AND CATHINE IN FALSE-POSITIVE SAMPLES FOR AMPHETAMINE BY IMMUNOASSAY TECHNIQUES [PDF]
Egyptian Society of Clinical Toxicology Journal, 2014 Introducation: The use of Khat trend is increasing among higher education students in Jazan region. Immunoassay techniques are used in the poison control and forensic medical chemistry center in Assir region to screen the urine samples for the presence ...
Mohamed Siam +4 more
doaj +1 more source