Results 61 to 70 of about 3,347 (210)

Stability of Synthetic Cathinones in Urine [PDF]

Journal of Analytical Toxicology, 2017
In this report, we evaluate the concentration, pH, temperature and analyte-dependent effects on cathinone stability in preserved human urine. A total of 22 synthetic cathinones were evaluated at 100 ng/mL and 1,000 ng/mL in pH 4 and pH 8 urine over 6 months. Specimens were stored at -20°C, 4°C, 20°C and 32°C.
Lindsay, Glicksberg, Sarah, Kerrigan
openaire   +2 more sources

Amphetamine-like effects in humans of the khat alkaloid cathinone.

, 1990
1. The chewing of khat leaves as a stimulant is common in certain countries, and the effects of this material are supposed to be due to the phenylalkylamine alkaloid cathinone.
Brenneisen R, Fisch HU, Geisshüsler S, Kalix P, Koelbing U   +4 more
core   +1 more source

Prevalence of novel psychoactive substances in selected clinical urine specimens submitted for drug monitoring

Journal of Forensic Sciences, EarlyView.
Abstract Novel psychoactive substances (NPS) are compounds emerging as alternatives to more established drugs of abuse. They are constantly changing and being modified, which makes their detection difficult. The study objective was to determine the prevalence of NPS in selected clinical specimens. Deidentified urine specimen remnants were analyzed that
Jillian R. Neifeld, Theresa M. Meli, Sarah H. Bartock   +2 more
wiley   +1 more source

From emergence to replacement: The evolution of 3‐methylmethcathinone (3‐MMC) and its substitutes in the Dutch drug market (2012–2024)

Addiction, EarlyView.
Abstract Background and aims The market for new psychoactive substances (NPS) is highly dynamic, with hundreds of substances emerging on the European drug market in the last decade. 3‐methylmethcathinone (3‐MMC), a synthetic cathinone and isomer of mephedrone (4‐MMC), gained popularity in the Netherlands due to its psychostimulant effects and initial ...
Nadia Robert Petronella Wilhelmina Hutten, Pieter Edmond Oomen, Frederiek Schutten, Margriet Walburga van Laar, Laura Alexandra Smit‐Rigter   +4 more
wiley   +1 more source

Oral White Lesions Associated with Chewing Khat

Tobacco Induced Diseases, 2004
Introduction Khat is a cultivated plant whose leaves when chewed elevate mood. Unlike the chewing of betel nut, no association between the white oral mucosal lesions in khat users and oral malignancies has been reported.
Meir Gorsky, Joel B. Epstein, Harel Levi, Noam Yarom   +3 more
doaj   +1 more source

Spectroscopic and Crystallographic Characterization of Two Hydrochloride Cathinones: 1-(4-fluoro-3-methylphenyl)-2-(pyrrolidin-1-yl)pentan-1-one (4-F-3-Me-α-PVP) and N-ethyl-2-amino-1-phenylheptan-1-one (N-ethylheptedrone)

Crystals, 2023
In this paper, two cathinone derivatives, 4F-3Me-α-PVP and N-ethylheptedrone, seized on the illegal drug market in Poland, were described and characterized by various instrumental analytical methods.
Marcin Rojkiewicz, Piotr Kuś, Joachim Kusz, Maria Książek, Dorota Staszek   +4 more
doaj   +1 more source

Para-Halogenation Affects Monoamine Transporter Inhibition Properties and Hepatocellular Toxicity of Amphetamines and Methcathinones

Frontiers in Pharmacology, 2019
Halogenated derivatives of amphetamine-type stimulants are appearing on the drug market, often with altered pharmacological profile and sometimes different legal status compared to the non-halogenated substances.
Dino Luethi, Melanie Walter, Xun Zhou, Deborah Rudin, Stephan Krähenbühl, Stephan Krähenbühl, Matthias E. Liechti   +6 more
doaj   +1 more source

Comprehensive in vitro profiling of traditional and emerging stimulants at monoamine transporters and the 5‐HT2A receptor

British Journal of Pharmacology, Volume 183, Issue 19, Page 5871-5894, October 2026.
A pharmacological profiling of 58 synthetic stimulants of various classes at dopamine, norepinephrine, and serotonin transporters and the 5‐HT2A receptor, most showing distinct class‐dependent profiles, with some indicating a high abuse potential. Background and Purpose New psychoactive substances (NPSs) often emerge on the illicit drug market with ...
Darta Stalberga, Robert Kronstrand, Bianca Schranz, Nick van Zijl, Sebastian Karlman, Soma Aref, Tobias Rautio, Svante Vikingsson, Mattias Persson, Henrik Green   +9 more
wiley   +1 more source

Molecular docking study of binding modes of amphetamine, cathine, and cathinone to monoamine oxidase B

Al-Azhar Assiut Medical Journal, 2019
Background Molecular docking is commonly used in the study of small-molecule–protein interaction. Amphetamine (AMPH), cathine (CATHI), and cathinone (CATHO) bind in silico with monoamine oxidase B (MAO B) with relatively low affinity.
Jerah A Ahmed
doaj   +1 more source

Prevalence, Patterns and Implications of Chemsex Substance Use Among Gay and Bisexual Men Who Have Sex With Men: A Cohort‐Collaboration Between the Swiss HIV Cohort Study and the SwissPrEPared Study

Journal of the International AIDS Society, Volume 29, Issue 9, September 2026.
ABSTRACT Introduction Global awareness to chemsex, a specific form of sexualized psychoactive substance (“chems”) use among gay, bisexual and other men who have sex with men (gbMSM), is increasing. We aimed to assess prevalence, patterns and implications of “chems” use on chemsex‐related outcomes.
Bashkim Jaha, Andrea Farnham, Roger Kouyos, Jan Fehr, Babette L. Winter, Irene A. Abela, Marcel Stöckle, Bernard Surial, Matteo Reymond, Matthias Cavassini, David Jackson‐Perry, Luigia Elzi, Julia Notter, Benjamin Hampel, Katharina Kusejko   +14 more
wiley   +1 more source