Results 1 to 10 of about 99,803 (245)

Physiological and Putative Organic Cation Transporter Expression Response to Alizarin Dye Exposure in <i>Aedes aegypti</i> Mosquitoes. [PDF]

Insects
There remains an urgent need for knowledge regarding the molecular and genetic mechanisms in Aedes aegypti to support the fight against mosquito-borne illness, one of these areas being xenobiotic transport.
Kennel NR, Rouhier MF.
europepmc   +2 more sources

Structural and functional mapping of ion access pathways in the human K⁺-dependent Na⁺/Ca²⁺ exchanger NCKX2 using cysteine scanning mutagenesis, thiol-modifying reagents, and homology modelling. [PDF]

Channels (Austin)
K+-dependent Na+/Ca2+ exchanger proteins (NCKX) are members of the CaCA superfamily with critical roles in vision, skin pigmentation, enamel formation, and neuronal functions.
Szerencsei RT, Cai S, Zhekova HR, Jalloul AH, Tieleman DP, Schnetkamp PPM.   +5 more
europepmc   +2 more sources

The molecular mechanism of fluoride export by the eukaryotic fluoride channel FEX. [PDF]

Nat Commun
Much of life on Earth, including plants, fungi, and bacteria, evolved to resist toxic environmental fluoride. In eukaryotes, the major resistance mechanism is fluoride export by membrane proteins known as FEX. Using electrophysiology and transport assays,
Kang CY, An M, Heidari S, Torabifard H, Ohi MD, Stockbridge RB.   +5 more
europepmc   +2 more sources

Light-Modulated Cationic and Anionic Transport Across Protein Biopolymers [PDF]

Angewandte Chemie International Edition, 2021
Light is a convenient source of energy and the heart of light-harvesting natural systems and devices. Here, we show light-modulation of both the chemical nature and ionic charge carrier concentration within a protein-based biopolymer that was covalently functionalized with photoacids or photobases.
Alex Burnstine‐Townley, Somen Mondal, Yuval Agam, Ramesh Nandi, Nadav Amdursky   +4 more
openaire   +2 more sources

In vitro Assay to Evaluate Cation Transport of Ionophores

Bio-Protocol, 2022
Ion homeostasis is a fundamental regulator of cellular processes and depends upon lipid membranes, which function as ion permeability barriers. Ionophores facilitate ion transport across cell membranes and offer a way to manipulate cellular ion ...
Huriye Huriye D. Uzun, Melissa Vázquez-Hernández, Julia Bandow, Thomas Günther Pomorski   +3 more
doaj   +1 more source

Bioinformatic characterization of the Anoctamin Superfamily of Ca2+-activated ion channels and lipid scramblases. [PDF]

PLoS ONE, 2018
Our laboratory has developed bioinformatic strategies for identifying distant phylogenetic relationships and characterizing families and superfamilies of transport proteins.
Arturo Medrano-Soto, Gabriel Moreno-Hagelsieb, Daniel McLaughlin, Zachary S Ye, Kevin J Hendargo, Milton H Saier   +5 more
doaj   +1 more source

Cation and sugar selectivity determinants in a novel family of transport proteins [PDF]

Molecular Microbiology, 1996
A new family of homologous membrane proteins that transport galactosides–pentoses–hexuronides (GPH) is described. By analysing the aligned amino acid sequences of the GPH family, and by exploiting their different specificities for cations and sugars, we have designed mutations that yield novel insights into the nature of ligand binding sites in ...
B, Poolman, J, Knol, C, van der Does, P J, Henderson, W J, Liang, G, Leblanc, T, Pourcher, I, Mus-Veteau   +7 more
openaire   +3 more sources

Rescue of Misfolded Organic Cation Transporter 3 Variants

Cells, 2022
Organic cation transporters (OCTs) are membrane proteins that take up monoamines, cationic drugs and xenobiotics. We previously reported novel missense mutations of organic cation transporter 3 (OCT3, SLC22A3), some with drastically impacted transport ...
Thomas J. F. Angenoorth, Julian Maier, Stevan Stankovic, Shreyas Bhat, Sonja Sucic, Michael Freissmuth, Harald H. Sitte, Jae-Won Yang   +7 more
doaj   +1 more source

Kidney‐specific expression of a novel mouse organic cation transporter‐like protein [PDF]

FEBS Letters, 1997
Using the signal sequence trap method, we have cloned a novel 12‐membrane‐spanning transporter‐like protein, termed renal‐specific transporter (RST), from the mouse kidney. RST is a 553‐amino‐acid protein highly homologous to recently cloned organic cation transporters, e.g.
Mori, Kiyoshi, Ogawa, Yoshihiro, Ebihara, Ken, Aoki, Tomohiro, Tamura, Naohisa, Sugawara, Akira, Kuwahara, Takashi, Ozaki, Shoichi, Mukoyama, Masashi, Tashiro, Kei, Tanaka, Issei, Nakao, Kazuwa   +11 more
openaire   +2 more sources

Genome-wide analysis of the apple CaCA superfamily reveals that MdCAX proteins are involved in the abiotic stress response as calcium transporters

BMC Plant Biology, 2021
Background Calcium (Ca2+) plays an important role in plant growth and development, and the maintenance of calcium homeostasis is necessary for the survival of all plant species. Ca2+/H+ exchangers (CAXs) are a subgroup of the CaCA (Ca2+/cation antiporter)
Ke Mao, Jie Yang, Min Wang, Huayu Liu, Xin Guo, Shuang Zhao, Qinglong Dong, Fengwang Ma   +7 more
doaj   +1 more source