Results 31 to 40 of about 99,803 (245)
Intestinal OCTN2- and MCT1-targeted drug delivery to improve oral bioavailability
Asian Journal of Pharmaceutical Sciences, 2020 Various drug transporters are widely expressed throughout the intestine and play important roles in absorbing nutrients and drugs, thus providing high quality targets for the design of prodrugs or nanoparticles to facilitate oral drug delivery.
Gang Wang +8 more
doaj +1 more source
A human transporter protein that mediates the final excretion step for toxic organic cations [PDF]
Proceedings of the National Academy of Sciences, 2005 In mammals, toxic electrolytes of endogenous and exogenous origin are excreted through the urine and bile. Before excretion, these compounds cross numerous cellular membranes in a transporter-mediated manner. However, the protein transporters involved in the final excretion step are poorly understood.
Otsuka, Masato +5 more
openaire +3 more sources
Frontiers in Cell and Developmental Biology, 2019 Ciliated cells exploit a specific transport system, the intraflagellar transport (IFT) system, to ensure the traffic of molecules from the cell body to the cilium.
Francesca Finetti +2 more
doaj +1 more source
Cation Effects on Protein Conformation and Transport in the Na+/Glucose Cotransporter
Journal of Biological Chemistry, 1997 Cation-driven cotransporters are essential membrane proteins in procaryotes and eucaryotes, which use the energy of the transmembrane electrochemical gradient to drive transport of a substrate against its concentration gradient. Do they share a common mechanism?
B A, Hirayama, D D, Loo, E M, Wright
openaire +2 more sources
Biophysics and Physicobiology, 2020 Microbial rhodopsin is a large family of membrane proteins having seven transmembrane helices (TM1-7) with an all-trans retinal (ATR) chromophore that is covalently bound to Lys in the TM7. The Trp residue in the middle of TM3, which is homologous to W86
Yujiro Nagasaka +6 more
doaj +1 more source
The mystery of the human proton-organic cation antiporter: One transport protein or many?
Pharmacology & Therapeutics, 2022 About 30% of all small molecular drugs are organic cations (OCs). If these are more or less hydrophilic, they require membrane transporters to pass through biological membranes. Here, the proton-organic cation (H+ OC) antiporter may play a physiologically most relevant role, particularly concerning passage through the blood-brain barrier.
Sachkova, Alexandra +4 more
openaire +3 more sources
Scientific ReportsPlant aquaporins (AQPs) were initially described as a family of membrane-localized proteins exclusively facilitating water transport. Subsequently, sub-sets of plant AQPs have exhibited diverse functionalities beyond water transport. The aquaporin AtPIP2;
Jiaen Qiu +3 more
doaj +1 more source
The Plant Genome, 2022 Metal‐tolerance proteins (MTPs) are divalent cation transporters and play fundamental roles in plant metal tolerance and ion homeostasis. Despite that, a systematic investigation of MTPs in Cucurbitacea is still lacking.
Xinchen Jiang +7 more
doaj +1 more source
Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
Frontiers in Cardiovascular Medicine, 2021 Lysosomal dysfunction has been found in many pathological conditions, and methods to improve lysosomal function have been reported to be protective against infarcted hearts.
Lin Cui +11 more
doaj +1 more source