Results 61 to 70 of about 96,494 (250)
Generalizing Experimental Findings
Journal of Causal Inference, 2015 This note examines one of the most crucial questions in causal inference: “How generalizable are randomized clinical trials?” The question has received a formal treatment recently, using a non-parametric setting, and has led to a simple and general ...
Pearl Judea
doaj +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Journal of Causal Inference, 2017 1 In this paper, we study the effect of a time-varying exposure mediated by a time-varying intermediate variable. We consider general longitudinal settings, including survival outcomes.
Zheng Wenjing, van der Laan Mark
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Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Data-Adaptive Causal Effects and Superefficiency
Journal of Causal Inference, 2016 Recent approaches in causal inference have proposed estimating average causal effects that are local to some subpopulation, often for reasons of efficiency.
Aronow Peter M.
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FEBS Open Bio, EarlyView.This research protocol outlines a workflow for nuclear magnetic resonance (NMR)‐based metabolomics in the agri‐food sector. Using two case studies—strawberry leaves (solid matrix) and wine (liquid matrix)—it details the procedures for sample preparation, data acquisition, and processing.
Andrea Fernández‐Veloso +4 more
wiley +1 more source
Physical and Metaphysical Counterfactuals: Evaluating Disjunctive Actions
Journal of Causal Inference, 2017 The structural interpretation of counterfactuals as formulated in Balke and Pearl (1994a,b) [1, 2] excludes disjunctive conditionals, such as “had X$X$ been x1 or x2$x_1~\mbox{or}~x_2$,” as well as disjunctive actions such as do(X=x1 or X=x2)$do(X=x_1 ...
Pearl Judea
doaj +1 more source
Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion
FEBS Open Bio, EarlyView.Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng +2 more
wiley +1 more source
Bayesian Inference of Causal Effects for an Ordinal Outcome in Randomized Trials
Journal of Causal Inference, 2018 In randomized trials in which two treatment arms are compared with a binary outcome, the causal effect can be identified by assuming that the two treatment arms are exchangeable.
Chiba Yasutaka
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MiR‐513a promotes human erythroid differentiation by modulating c‐Jun
FEBS Open Bio, EarlyView.During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim +11 more
wiley +1 more source