MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Heterogeneous causal mediation analysis using Bayesian additive regression trees. [PDF]
BiometricsLiu C, Qin X, Talisa VB, Wang J.
europepmc +1 more source
Causal Mediation Analysis With Treatment Noncompliance
When evaluating a new intervention, we often seek causality, which we may estimate by the intervention's average treatment effect. When interest is in the causal mechanism, causal mediation analysis is more appropriate.
Lind, Miriam
core
Nonlinear mediation in clustered data : a nonlinear multilevel mediation model
, 2013 textMediational analysis quantifies proposed causal mechanisms through which treatments act on outcomes. In the presence of clustered data, conventional multiple regression mediational methods break down, requiring the use of hierarchical linear modeling
Lockhart, Lester Leland
core
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Longitudinal biological aging trajectories and incident urolithiasis: a causal mediation analysis role of metabolic dysfunction in a large Chinese cohort. [PDF]
Front Endocrinol (Lausanne)Wang J +5 more
europepmc +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Life course adversity and risk of incident atrial fibrillation: causal mediation analysis of psychological distress in the population-based Tromsø Study. [PDF]
BMJ Public HealthCaglayan S, Grønli OK, Høye A.
europepmc +1 more source
A literature review and meta-analysis of causal mediation analysis in social psychology
For several decades, researchers in the field of social psychology have used mediation analysis. Despite their popularity, traditional approaches like the Baron and Kenny or Preacher and Hayes models have limitations, including lack of formal causal ...
Jiwoo Kim, Felix Thoemmes, Anthony Ong
core +1 more source