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An Introduction to Causal Mediation Analysis With a Comparison of 2 R Packages [PDF]
Journal of Preventive Medicine and Public Health, 2023 Traditional mediation analysis, which relies on linear regression models, has faced criticism due to its limited suitability for cases involving different types of variables and complex covariates, such as interactions.
Sangmin Byeon, Woojoo Lee
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Role of covariates in the analysis of causal mediation effects
Sichuan jingshen weisheng, 2022 The purpose of this paper was to introduce the theoretical basis of the causal mediation effect analysis and the specific method to realize an example by the causal mediation effect analysis with SAS.
Hu Chunyan, Hu Liangping
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Key technology and multi-directional decomposition method of the causal mediation effect analysis
Sichuan jingshen weisheng, 2022 The purpose of this paper was to introduce five key techniques and the multi-directional decomposition methods of effect components in the analysis of causal mediation effects.
Hu Chunyan, Hu Liangping
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Frontiers in Public Health, 2023 IntroductionPhysical fitness is an essential part of a healthy lifestyle that concerns the overall health of the nation. Research on the relationship between the Internet and physical fitness has long been caught in the dilemma of “media mobilization ...
Long Zhang +6 more
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Mediation analysis methods used in observational research: a scoping review and recommendations
BMC Medical Research Methodology, 2021 Background Mediation analysis methodology underwent many advancements throughout the years, with the most recent and important advancement being the development of causal mediation analysis based on the counterfactual framework.
Judith J. M. Rijnhart +5 more
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Investigating potential mediator between statin and coronary artery calcification. [PDF]
PLoS ONE, 2018 Statins are mainstay anti-lipidaemic treatments for preventing cardiovascular diseases but also known to increase coronary artery calcification (CAC). However, underlying relationship between statin and CAC is still unclear.
Donghun Lee +3 more
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Frontiers in Endocrinology, 2022 BackgroundType 2 diabetes mellitus (T2DM) and hypertension commonly coexist, and we presumed that T2DM might mediate the relationship between some shared risk factors and systolic blood pressure (SBP).MethodsThe causal association between T2DM and SBP ...
Xuezeng Hao +3 more
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Frontiers in Nutrition, 2023 PurposeObservational studies have increasingly recognized the influence of gut microbes on blood pressure modulation. Despite these findings, a direct causal link between gut flora and hypertension remains unestablished due to inherent confounders and ...
Shiyao Zhao +3 more
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High-Dimensional DNA Methylation Mediates the Effect of Smoking on Crohn’s Disease
Frontiers in Genetics, 2022 Epigenome-wide mediation analysis aims to identify high-dimensional DNA methylation at cytosine–phosphate–guanine (CpG) sites that mediate the causal effect of linking smoking with Crohn’s disease (CD) outcome.
Tingting Wang, Pingtian Xia, Ping Su
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Frontiers in Cardiovascular Medicine, 2022 ObjectiveThe objective of this study is to investigate the roles of cardiometabolic factors (including blood pressure, blood lipids, thyroid function, body mass, and insulin sensitivity) in mediating the causal effect of type 2 diabetes (T2DM) on ...
Ken Chen +20 more
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