Results 21 to 30 of about 10,493,362 (203)

Causal mediation analysis.

, 2018
Causal mediation analysis.
Omer Yair (5172014), Raanan Sulitzeanu-Kenan (5172011)   +1 more
core   +2 more sources

MRLocus: Identifying causal genes mediating a trait through Bayesian estimation of allelic heterogeneity.

PLoS Genetics, 2021
Expression quantitative trait loci (eQTL) studies are used to understand the regulatory function of non-coding genome-wide association study (GWAS) risk loci, but colocalization alone does not demonstrate a causal relationship of gene expression ...
Anqi Zhu, Nana Matoba, Emma P Wilson, Amanda L Tapia, Yun Li, Joseph G Ibrahim, Jason L Stein, Michael I Love   +7 more
doaj   +1 more source

Anisodamine hydrobromide reduces 28-day mortality in septic shock: a randomized controlled

Frontiers in Pharmacology
BackgroundThis randomized controlled trial evaluated whether anisodamine hydrobromide reduces 28-day mortality in septic shock and whether this effect is mediated by lactate and lactate clearance.MethodsIn this prospective randomized controlled trial ...
Xueting Yang, Hongqiong Peng, Tianmeng Pan, Ting Xie, Lei Deng, Ping Zhou, Yijin Chen, Mingxin Xie, Han Zeng, Xia Zeng, Ting Wang   +10 more
doaj   +1 more source

Social Functioning Within the First Years After Pediatric Brain Tumor Diagnosis and the Relationship With Family Psychosocial Risk

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Survivors of pediatric brain tumors (PBTs) can experience long‐term social difficulties, impacting quality of life. Beyond medical and environmental factors, family psychosocial risk may play a role in social outcomes by shaping the caregiving environment and may provide intervention options.
Renske H. Houben, Marisa H. Huisman, Martha A. Grootenhuis, Femke K. Aarsen, Marita Partanen   +4 more
wiley   +1 more source

Impact of Telemedicine Adoption on Hemiplegia in Patients With Stroke in Florida: Longitudinal Observational Study

Journal of Medical Internet Research
BackgroundTelemedicine has emerged as a critical tool in the management of acute stroke; yet, its impact on clinical decision-making, particularly in the administration of tissue plasminogen activator (tPA), remains underexplored.
Yao Li, Mingshan Zhang, Weiling Ke, Wenwen Li   +3 more
doaj   +1 more source

Retrospective Analysis of Donor Lymphocyte Infusions in Pediatric Patients With Mixed Chimerism After Hematopoietic Stem Cell Transplantation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Allogeneic hematopoietic stem cell transplantation (alloHSCT) is an essential therapy for several malignant and nonmalignant diseases, but relapse and graft loss remain the principal threats to its success. Routine monitoring of chimerism and minimal residual disease (MRD) enables early detection of imminent recurrence and guides ...
Carmen Junk, Sebastian Michaelis, Michaela Döring, Thomas Eichholz, Ursula Holzer, Martin Ebinger, Tim Flaadt, Rupert Handgretinger, Peter Lang, Jan Frederic Weller, Markus Mezger   +10 more
wiley   +1 more source

Causal mediation analysis decomposition of between-hospital variance [PDF]

, 2021
Causal variance decompositions for a given disease-specific quality indicator can be used to quantify differences in performance between hospitals or health care providers.
Lawson, Keith A., Saarela, Olli, Finelli, Antonio, Chen, Bo, Olli Saarela, Antonio Finelli, Bo Chen, Keith A. Lawson   +7 more
core   +1 more source

Biphasic Clinical Course of Pediatric Cytomegalovirus‐Associated Immune Thrombocytopenia: Early Poor Treatment Response but Favorable Long‐Term Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Cytomegalovirus (CMV) is a recognized trigger of immune thrombocytopenia (ITP); however, its incidence and impact on disease course in children remain controversial. Therefore, we aimed to characterize the clinical course of pediatric patients with CMV‐associated ITP.
Oded Gilad, Ohad Atia, Osama Tanous, Dafna Brik Simon, Michal Dvori, Miriam Cohen, Tracie A. Goldberg, Efraim Bilavsky, Joanne Yacobovich, Orna Steinberg‐Shemer   +9 more
wiley   +1 more source

Nonlinear mediation in clustered data : a nonlinear multilevel mediation model [PDF]

, 2013
textMediational analysis quantifies proposed causal mechanisms through which treatments act on outcomes. In the presence of clustered data, conventional multiple regression mediational methods break down, requiring the use of hierarchical linear modeling
Lockhart, Lester Leland
core   +1 more source

Body mass index, smoking behavior, and depression mediated the effects of schizophrenia on chronic obstructive pulmonary disease: trans-ethnic Mendelian-randomization analysis

Frontiers in Psychiatry
BackgroundPrevious studies have highlighted the association between schizophrenia (SCZ) and chronic obstructive pulmonary disease (COPD), yet the causal relationship remains unestablished.MethodsUnder the genome-wide significance threshold (P<5×10–8),
Yao Ni, DaWei Zhang, DaWei Zhang, Wenlong Tang, Liming Xiang, Xiaoding Cheng, Youqian Zhang, Yanyan Feng   +7 more
doaj   +1 more source