Results 201 to 210 of about 64,095 (292)

Menopause May Partially Explain Age-Related Increased Risk of MASLD Fibrosis: A Causal Mediation Analysis. [PDF]

Clin Gastroenterol Hepatol
Sokale IO, Liu Y, El-Serag HB, Kanwal F, Thrift AP, Balakrishnan M.   +5 more
europepmc   +1 more source

Causal Mediation Analysis with Multiple Mediators

Causal mediation analysis aims to determine the mechanism behind a variable, which is referred to as exposure, causing the value of the outcome variable. In mediation analysis, the effect can be direct or be mediated via one or more mediators.
Chakhovich, Anton
core  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Causal mediation analysis: what is it and how can it be used to inform practice and policy? [PDF]

Fam Pract
Fernainy P, Godard-Sebillotte C, Lacasse A, Layani G, Longo C, Kaczorowski J, Rodriguez MA, Poitras ME, Breton M, Lussier MT, Couturier Y, Hudon C, Sourial N.   +12 more
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Assessing the Impact of Waiting Time on Triage Color Code Assignment and One-Year Mortality in the Emergency Department: A Causal Mediation Analysis. [PDF]

Health Sci Rep
Nurchis MC, Covino M, Savoia C, Altamura G, Cambieri A, Giubbini G, Vetrugno G, Cesare M, Cocchieri A, Franceschi F, Ricciardi W, Damiani G.   +11 more
europepmc   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Causal mediation analysis for time-varying heritable risk factors with Mendelian randomization. [PDF]

Nat Commun
Wu Z, Lewis E, Zhao Q, Wang J.
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source